IR@PKUHSC  > 北京大学第三临床医学院
学科主题临床医学
Complete blood count reference intervals and age-and sex-related trends of North China Han population
Qiao, Rui3; Yang, Shuo3; Yao, Bei3; Wang, Hongya3; Zhang, Jie1; Shang, Hong2
关键词Blood Cell Complete Blood Count Reference Intervals
刊名CLINICAL CHEMISTRY AND LABORATORY MEDICINE
2014-07-01
DOI10.1515/cclm-2012-0486
52期:7页:1025-1032
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medical Laboratory Technology
资助者National Key Technology RD Program ; Ministry of Health P.R. China ; National Key Technology RD Program ; Ministry of Health P.R. China
研究领域[WOS]Medical Laboratory Technology
关键词[WOS]MEN
英文摘要

Background: Defining common reference intervals (RIs) are encouraging. The aim of this study is to establish RIs for complete blood count (CBC) in a Chinese Han population and probe their age-and sex-related CBC trends. Additionally, we will compare the CBC RIs of Han with those of other races.

Methods: In total 1259 Han individuals (584 male and 675 female) were recruited in North China. CBC was processed on Sysmex XE-2100, Coulter LH750 and Mindray BC5800 whose traceability was well verified. The non-parametric 2.5th-97.5th percentiles RIs were calculated.

Results: The RIs for CBC parameters did not show apparent analyzer-specificity, apart from mean cellular volume (MCV), mean platelet volume (MPV), plateletcrit (PCT) and platelet distribution width (PDW). Red blood cell (RBC), hemoglobin (HBG), hematocrit (HCT), mean cellular hemoglobin (MCH), and mean cellular hemoglobin concentration (MGHC) are higher in males; and their male mean values tend to drop after 40 years; conversely, the female mean values tend to rise. Platelet (PLT) is higher in females and tends to drop after 40 years in both sexes. White blood cell (WBC) and absolute count of neutrophils (NE) and monocytes (MO) are higher in males, but there is no apparent change with age. Lymphocytes (LY) absolute count declines with age in males, but the same change in females is not obvious. RIs for HBG and HCT are similar among Han, Nordic, US European and US Mexican populations and are lower in US Africans. WBC RIs for Han and US African populations are lower than that for US Europeans and US Mexicans.

Conclusions: RIs for major blood cell parameters are not method-dependent; variations obviously exist in age, sex and race. Consequently, common RIs for most CBC parameters appear inapplicable.

语种英语
所属项目编号2012BAI37B01
资助者National Key Technology RD Program ; Ministry of Health P.R. China ; National Key Technology RD Program ; Ministry of Health P.R. China
WOS记录号WOS:000338852700021
Citation statistics
Cited Times:14[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54053
Collection北京大学第三临床医学院
作者单位1.Peking Univ, Dept Lab Med, Hosp 3, Beijing 100191, Peoples R China
2.China Med Univ, Dept Lab Med, Hosp 1, Shenyang 110001, Peoples R China
3.Peking Univ, Hosp 3, Beijing 100191, Peoples R China
Recommended Citation
GB/T 7714
Qiao, Rui,Yang, Shuo,Yao, Bei,et al. Complete blood count reference intervals and age-and sex-related trends of North China Han population[J]. CLINICAL CHEMISTRY AND LABORATORY MEDICINE,2014,52(7):1025-1032.
APA Qiao, Rui,Yang, Shuo,Yao, Bei,Wang, Hongya,Zhang, Jie,&Shang, Hong.(2014).Complete blood count reference intervals and age-and sex-related trends of North China Han population.CLINICAL CHEMISTRY AND LABORATORY MEDICINE,52(7),1025-1032.
MLA Qiao, Rui,et al."Complete blood count reference intervals and age-and sex-related trends of North China Han population".CLINICAL CHEMISTRY AND LABORATORY MEDICINE 52.7(2014):1025-1032.
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