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学科主题: 药学
题名:
Anti-inflammatory Labdane Diterpenoids from Lagopsis supina
作者: Li, Hui1,2; Li, Man-Man1,2; Su, Xiao-Qin1,2; Sun, Jing1,2; Gu, Yu-Fan1,2; Zeng, Ke-Wu3; Zhang, Qian1; Zhao, Yun-Fang1; Ferreira, Daneel4,5; Zjawiony, Jordan K.4,5; Li, Jun1; Tu, Peng-Fei1
刊名: JOURNAL OF NATURAL PRODUCTS
发表日期: 2014-04-01
DOI: 10.1021/np5001329
卷: 77, 期:4, 页:1047-1053
收录类别: SCI ; IC
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Plant Sciences ; Pharmacology & Pharmacy
关键词[WOS]: SPIROLABDANE-TYPE DITERPENOIDS ; LEONURUS-HETEROPHYLLUS ; LEOHETERIN ; SIBIRICUS
英文摘要:

Ten new labdane diterpenoids, lagopsins A-H (1-3, 5, 7-10) and 15-epi-lagopsins C and D (4, 6), together with five known labdane diterpenoids (11-15), were isolated from the whole plants of Lagopsis supina. The absolute configuration of lagopsin A (1) was determined by single-crystal X-ray crystallographic analysis. Compounds 7, 9, 13, and 15 exhibited moderate inhibition of nitric oxide production stimulated by lipopolysaccharide in BV-2 microglial cells with IC50 values in the range 4.9-34.9 mu M.

语种: 英语
所属项目编号: NCET-13-0693 ; 2013-JYBZZ-JS-136
项目资助者: Program for New Century Excellent Talents in University ; Beijing University of Chinese Medicine ; Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry
WOS记录号: WOS:000335127200042
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54066
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Beijing Univ Chinese Med, Modern Res Ctr Tradit Chinese Med, Beijing 100029, Peoples R China
2.Beijing Univ Chinese Med, Sch Chinese Mat Med, Beijing 100102, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
4.Univ Mississippi, Sch Pharm, Dept Pharmacognosy, University, MS 38677 USA
5.Univ Mississippi, Sch Pharm, Pharmaceut Sci Res Inst, University, MS 38677 USA

Recommended Citation:
Li, Hui,Li, Man-Man,Su, Xiao-Qin,et al. Anti-inflammatory Labdane Diterpenoids from Lagopsis supina[J]. JOURNAL OF NATURAL PRODUCTS,2014,77(4):1047-1053.
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