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学科主题: 临床医学
题名:
Marginal living donor in kidney transplantation: experience in a Chinese single center
作者: Li Gang1; Wang Yun-peng1; Ma Lu-lin1; Zhang Jing2; Zhang Hong-xian1; Huang Yi1; Hou Xiao-fei1; Xiao Chun-lei1; Zhao Lei1; Wang Guo-liang1; Tian Xiao-jun1; Qiu Min1; Zheng Yi1
关键词: kidney transplantation ; marginal ; non-marginal ; living donor
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2013-08-05
DOI: 10.3760/cma.j.issn.0366-6999.20130454
卷: 126, 期:15, 页:2810-2814
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: RENAL-FUNCTION ; RECIPIENTS ; DIALYSIS ; DONATION ; PROGRAM
英文摘要:

Background Living donor kidney transplantation is becoming popular in China, whereas, in clinical situations, some kidney donors may be sub-optimal, namely marginal living donor. The present study aimed to evaluate the safety and efficacy of marginal living donor kidney transplantation in a Chinese single center.

Methods Between January 2001 and December 2009, 888 kidney transplantations were performed in our center; 149 were living donor kidney transplantations. The living donors and recipients were followed up regularly after the operation. Of the living donors, 30 donors were marginal, who were older than 60 years or suffered from kidney anomaly or some benign diseases. Among the non-marginal living kidney transplantations, 58 donors and recipients had complete perk operative and follow-up data. We compared the marginal and non-marginal living donor kidney transplantations with regard to donor age, follow-up period, donor′s serum creatinine at the last follow-up, recipient′s serum creatinine at the last follow-up, and graft survival at the last follow-up.

Results The mean age of donors in the marginal and non-marginal living donors were (55 +/- 9) (37-66) and (43 +/- 12) (30-59) years. The mean follow-up times of the marginal and non-marginal groups were (26.4 +/- 13.4) months and (28.8 +/- 14.8) months. The donor and recipient serum creatinine levels at the last follow-up were (1.16 +/- 0.20) mg/dl and (1.30 +/- 0.24) mg/dl in the marginal group, and (1.12 +/- 0.32) mg/dl and (1.34 +/- 0.32) mg/dl in the non-marginal group. Three recipients in the marginal group and five recipients in the non-marginal group had acute rejection episodes during the first year. Actuarial 3-year graft survival was 96.7% in the marginal group and 100% in the non-marginal group. No significant differences were detected between the two groups with regard to these data.

Conclusion Utilization of highly selective marginal living donors can be a safe, feasible, and effective way for the treatment of patients with end stage renal disease.

语种: 英语
WOS记录号: WOS:000329015500003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54068
Appears in Collections:北京大学第三临床医学院_泌尿外科_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Dept Urol, Beijing 100191, Peoples R China
2.Navy Gen Hosp, Dept Special Med, Beijing 100048, Peoples R China

Recommended Citation:
Li Gang,Wang Yun-peng,Ma Lu-lin,et al. Marginal living donor in kidney transplantation: experience in a Chinese single center[J]. CHINESE MEDICAL JOURNAL,2013,126(15):2810-2814.
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