IR@PKUHSC  > 北京大学药学院  > 分子与细胞药理学系
学科主题药学
Alternol inhibits proliferation and induces apoptosis in mouse lymphocyte leukemia (L1210) cells
Liu, Zhao-Zhe; Zhu, Jin; Sun, Bo; Liu, Shu; Geng, Shuo; Liu, Xia; Li, Chang-Ling
关键词Alternol L1210 Apoptosis Leukemia
刊名MOLECULAR AND CELLULAR BIOCHEMISTRY
2007-12-01
DOI10.1007/s11010-007-9560-0
306期:1-2页:115-122
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology
研究领域[WOS]Cell Biology
关键词[WOS]OXIDATIVE STRESS ; CYTOCHROME-C ; GENE-THERAPY ; DNA-DAMAGE ; DEATH ; BCL-2 ; P53 ; TAXOL ; MITOCHONDRIA ; INVOLVEMENT
英文摘要

Alternol is a novel compound purified from the fermenting products by microorganisms named as Alternaria alternata var. monosporus from the bark of Yew. In this study, we tested its effect on mouse lymphocyte leukemia L1210 cells. Alternol was found to inhibit the proliferation and induce apoptosis in L1210 cells. When the cells were treated with Alternol, chromatin condensation and phosphatidylserine externalization were observed with the down-regulation of the pro-survival gene Bcl-2 and the activation of caspase-3, caspase-9, but not caspase-8. Moreover, exposure of cells to Alternol resulted in a significant increase in reactive oxygen species (ROS) and mitochondrial transmembrane potential (Delta Psi m) depolarization. Taken together, these results demonstrate that Alternol is a potent agent in inducing L1210 cells to apoptosis, which involve caspase activation and ROS generation.

语种英语
WOS记录号WOS:000250304900014
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54078
专题北京大学药学院_分子与细胞药理学系
作者单位1.Peking Univ, Sch Pharmaceut Sci, Hlth Sci Ctr, Dept Pharmacol, Beijing 100083, Peoples R China
2.Chinese Acad Sci, Inst Zool, Natl Key Lab Biomembrane & Membrane Biotechnol, Beijing 100080, Peoples R China
3.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714
Liu, Zhao-Zhe,Zhu, Jin,Sun, Bo,et al. Alternol inhibits proliferation and induces apoptosis in mouse lymphocyte leukemia (L1210) cells[J]. MOLECULAR AND CELLULAR BIOCHEMISTRY,2007,306(1-2):115-122.
APA Liu, Zhao-Zhe.,Zhu, Jin.,Sun, Bo.,Liu, Shu.,Geng, Shuo.,...&Li, Chang-Ling.(2007).Alternol inhibits proliferation and induces apoptosis in mouse lymphocyte leukemia (L1210) cells.MOLECULAR AND CELLULAR BIOCHEMISTRY,306(1-2),115-122.
MLA Liu, Zhao-Zhe,et al."Alternol inhibits proliferation and induces apoptosis in mouse lymphocyte leukemia (L1210) cells".MOLECULAR AND CELLULAR BIOCHEMISTRY 306.1-2(2007):115-122.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Liu, Zhao-Zhe]的文章
[Zhu, Jin]的文章
[Sun, Bo]的文章
百度学术
百度学术中相似的文章
[Liu, Zhao-Zhe]的文章
[Zhu, Jin]的文章
[Sun, Bo]的文章
必应学术
必应学术中相似的文章
[Liu, Zhao-Zhe]的文章
[Zhu, Jin]的文章
[Sun, Bo]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。