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学科主题: 基础医学
题名:
Downregulation of miR-193a-5p correlates with lymph node metastasis and poor prognosis in colorectal cancer
作者: Zhang, Peng1; Ji, Deng-Bo1; Han, Hai-Bo2; Shi, Yun-Fei3; Du, Chang-Zheng1; Gu, Jin1
关键词: miR-193a-5p ; Colorectal cancer ; Lymph node metastasis ; Prognosis ; Biomarker
刊名: WORLD JOURNAL OF GASTROENTEROLOGY
发表日期: 2014-09-14
DOI: 10.3748/wjg.v20.i34.12241
卷: 20, 期:34, 页:12241-12248
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
关键词[WOS]: SQUAMOUS-CELL CARCINOMA ; BREAST-CANCER ; TUMOR MICROENVIRONMENT ; EXPRESSION ; MICRORNAS ; INVASION ; GROWTH ; OVEREXPRESSION ; TUMORIGENESIS ; BIOMARKERS
英文摘要:

AIM: To investigate the correlation of miR-193a-5p with lymph node metastasis and postoperative survival of colorectal cancer (CRC) patients.

METHODS: A total of 304 formalin-fixed, paraffin-embedded specimens (69 paired cancer and normal tissues, 55 primary tumors of stage III CRC and matched lymph nodes, and 56 primary tumors of stage II CRC) were included in this study. The relative expression levels of miR-193a-5p in the normal mucosa, primary cancer, and metastatic lymph node lesions were measured by quantitative real-time reverse transcriptase polymerase chain reaction. We evaluated the association of its expression with colorectal cancer lymph node metastasis, clinicopathological factors, and patient survival.

RESULTS: The relative expression level of miR-193a-5p was significantly lower in CRC tissues than in the normal mucosa (P = 0.0060). The expression levels of miR-193a-5p were lower in primary CRC tissues with lymph node metastases than in those without metastases (P = 0.0006), and decreased expression of miR-193a-5p correlated with advanced lymph node metastatic stage (P = 0.0007). Kaplan-Meier analysis showed that patients with low miR-193a-5p expression had decreased disease-free survival (DFS) (P = 0.0026) and poor overall survival (OS) (P = 0.0003). Interestingly, for the group of patients with lymph node metastases, miR-193a-5p expression was also related to survival. Patients with low miR-193a-5p expression had decreased DFS (P = 0.0262) and poor OS (P = 0.0230). Moreover, multivariate analysis indicated that downregulation of miR-193a-5p was an independent predictor of poor OS.

CONCLUSION: Downregulation of miR-193a-5p correlates with lymph node metastasis and poor survival of CRC. miR-193a-5p may be a useful biomarker for CRC diagnosis, metastasis and prognosis prediction. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.

语种: 英语
所属项目编号: 30872467 ; 81030040 ; 81201965 ; 81372593 ; 7132052 ; 2012AA02A506
项目资助者: National Natural Science Foundation of China ; Beijing Natural Science Foundation ; National High Technology Research and Development Program of China (863 Program)
WOS记录号: WOS:000341719100032
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54080
Appears in Collections:基础医学院_细胞生物学系_期刊论文

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作者单位: 1.Peking Univ, Canc Hosp & Inst, Key Lab Carcinogenesis & Translat Res, Minist Educ, Beijing 100142, Peoples R China
2.Peking Univ, Canc Hosp & Inst, Dept Cell Biol, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China
3.Peking Univ, Canc Hosp & Inst, Dept Pathol, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China

Recommended Citation:
Zhang, Peng,Ji, Deng-Bo,Han, Hai-Bo,et al. Downregulation of miR-193a-5p correlates with lymph node metastasis and poor prognosis in colorectal cancer[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2014,20(34):12241-12248.
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