IR@PKUHSC  > 北京大学基础医学院  > 细胞生物学系
学科主题基础医学
Downregulation of miR-193a-5p correlates with lymph node metastasis and poor prognosis in colorectal cancer
Zhang, Peng1; Ji, Deng-Bo1; Han, Hai-Bo2; Shi, Yun-Fei3; Du, Chang-Zheng1; Gu, Jin1
关键词Mir-193a-5p Colorectal Cancer Lymph Node Metastasis Prognosis Biomarker
刊名WORLD JOURNAL OF GASTROENTEROLOGY
2014-09-14
DOI10.3748/wjg.v20.i34.12241
20期:34页:12241-12248
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology
研究领域[WOS]Gastroenterology & Hepatology
关键词[WOS]SQUAMOUS-CELL CARCINOMA ; BREAST-CANCER ; TUMOR MICROENVIRONMENT ; EXPRESSION ; MICRORNAS ; INVASION ; GROWTH ; OVEREXPRESSION ; TUMORIGENESIS ; BIOMARKERS
英文摘要

AIM: To investigate the correlation of miR-193a-5p with lymph node metastasis and postoperative survival of colorectal cancer (CRC) patients.

METHODS: A total of 304 formalin-fixed, paraffin-embedded specimens (69 paired cancer and normal tissues, 55 primary tumors of stage III CRC and matched lymph nodes, and 56 primary tumors of stage II CRC) were included in this study. The relative expression levels of miR-193a-5p in the normal mucosa, primary cancer, and metastatic lymph node lesions were measured by quantitative real-time reverse transcriptase polymerase chain reaction. We evaluated the association of its expression with colorectal cancer lymph node metastasis, clinicopathological factors, and patient survival.

RESULTS: The relative expression level of miR-193a-5p was significantly lower in CRC tissues than in the normal mucosa (P = 0.0060). The expression levels of miR-193a-5p were lower in primary CRC tissues with lymph node metastases than in those without metastases (P = 0.0006), and decreased expression of miR-193a-5p correlated with advanced lymph node metastatic stage (P = 0.0007). Kaplan-Meier analysis showed that patients with low miR-193a-5p expression had decreased disease-free survival (DFS) (P = 0.0026) and poor overall survival (OS) (P = 0.0003). Interestingly, for the group of patients with lymph node metastases, miR-193a-5p expression was also related to survival. Patients with low miR-193a-5p expression had decreased DFS (P = 0.0262) and poor OS (P = 0.0230). Moreover, multivariate analysis indicated that downregulation of miR-193a-5p was an independent predictor of poor OS.

CONCLUSION: Downregulation of miR-193a-5p correlates with lymph node metastasis and poor survival of CRC. miR-193a-5p may be a useful biomarker for CRC diagnosis, metastasis and prognosis prediction. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.

语种英语
WOS记录号WOS:000341719100032
项目编号30872467 ; 81030040 ; 81201965 ; 81372593 ; 7132052 ; 2012AA02A506
资助机构National Natural Science Foundation of China ; Beijing Natural Science Foundation ; National High Technology Research and Development Program of China (863 Program)
引用统计
被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54080
专题北京大学基础医学院_细胞生物学系
北京大学第一临床医学院_泌尿外科
北京大学临床肿瘤学院_病理科
北京大学临床肿瘤学院_603课题组
北京大学临床肿瘤学院_结直肠肿瘤外科
作者单位1.Peking Univ, Canc Hosp & Inst, Key Lab Carcinogenesis & Translat Res, Minist Educ, Beijing 100142, Peoples R China
2.Peking Univ, Canc Hosp & Inst, Dept Cell Biol, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China
3.Peking Univ, Canc Hosp & Inst, Dept Pathol, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Peng,Ji, Deng-Bo,Han, Hai-Bo,et al. Downregulation of miR-193a-5p correlates with lymph node metastasis and poor prognosis in colorectal cancer[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2014,20(34):12241-12248.
APA Zhang, Peng,Ji, Deng-Bo,Han, Hai-Bo,Shi, Yun-Fei,Du, Chang-Zheng,&Gu, Jin.(2014).Downregulation of miR-193a-5p correlates with lymph node metastasis and poor prognosis in colorectal cancer.WORLD JOURNAL OF GASTROENTEROLOGY,20(34),12241-12248.
MLA Zhang, Peng,et al."Downregulation of miR-193a-5p correlates with lymph node metastasis and poor prognosis in colorectal cancer".WORLD JOURNAL OF GASTROENTEROLOGY 20.34(2014):12241-12248.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Downregulation of mi(1188KB)期刊论文出版稿开放获取CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zhang, Peng]的文章
[Ji, Deng-Bo]的文章
[Han, Hai-Bo]的文章
百度学术
百度学术中相似的文章
[Zhang, Peng]的文章
[Ji, Deng-Bo]的文章
[Han, Hai-Bo]的文章
必应学术
必应学术中相似的文章
[Zhang, Peng]的文章
[Ji, Deng-Bo]的文章
[Han, Hai-Bo]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Downregulation of miR-193a-5p correlates with lymph node metastasis and poor prognosis in colorectal cancer.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。