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Altered Small-World Brain Functional Networks in Children With Attention-Deficit/Hyperactivity Disorder
Wang, Liang1,2; Zhu, Chaozhe1; He, Yong3; Zang, Yufeng1; Cao, Qingjiu4; Zhang, Han1; Zhong, Qiuhai2; Wang, Yufeng4
关键词Adhd Connectivity Efficiency Functional Magnetic Resonance Imaging Networks Resting-state Small-world
刊名HUMAN BRAIN MAPPING
2009-02-01
DOI10.1002/hbm.20530
30期:2页:638-649
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]DEFICIT-HYPERACTIVITY DISORDER ; GRAPH-THEORETICAL ANALYSIS ; MAGNETIC-RESONANCE ; RESTING-STATE ; COMPLEX NETWORKS ; CEREBRAL-CORTEX ; CONNECTIVITY PATTERNS ; MORPHOMETRIC ANALYSIS ; CINGULATE CORTEX ; CORPUS-CALLOSUM
英文摘要

In this study, we investigated the changes in topological architectures of brain functional networks in attention-deficit/hyperactivity disorder (ADHD). Functional magnetic resonance images (fMRI) were obtained from 19 children with ADHD and 20 healthy controls during resting state. Brain functional networks were constructed by thresholding the correlation matrix between 90 cortical and subcortical regions and further analyzed by applying graph theoretical approaches. Experimental results showed that, although brain networks of both groups exhibited economical small-world topology, altered functional networks were demonstrated in the brain of ADHD when compared with the normal controls. In particular, increased local efficiencies combined with a decreasing tendency in global efficiencies found in ADHD Suggested a disorder-related shift of the topology toward regular networks. Additionally, significant alterations in nodal efficiency were also found in ADHD, involving prefrontal, temporal, and occipital cortex regions, which were compatible with previous ADHD studies. The present study provided the first evidence for brain dysfunction in ADHD from the viewpoint of global organization of brain functional networks by using resting-state fMRI. Hum Brain Mapp 30:638-649, 2009. (C) 2008 Wiley-Liss. Inc.

语种英语
WOS记录号WOS:000263232800024
项目编号2003CB716101 ; 30500130 ; 30621130074
资助机构National Key Basic Research and Development Program (973) ; Natural Science Foundation of China ; Chinese-Finnish NEURO Program ; Natural Science Foundation of China
引用统计
被引频次:254[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54083
专题北京大学精神卫生研究所
北京大学精神卫生研究所_精神科
作者单位1.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China
2.Beijing Inst Technol, Sch Informat Sci & Technol, Beijing 100081, Peoples R China
3.McGill Univ, Montreal Neurol Inst, McConnell Brain Imaging Ctr, Montreal, PQ H3A 2B4, Canada
4.Peking Univ, Inst Mental Hlth, Beijing 100083, Peoples R China
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GB/T 7714
Wang, Liang,Zhu, Chaozhe,He, Yong,et al. Altered Small-World Brain Functional Networks in Children With Attention-Deficit/Hyperactivity Disorder[J]. HUMAN BRAIN MAPPING,2009,30(2):638-649.
APA Wang, Liang.,Zhu, Chaozhe.,He, Yong.,Zang, Yufeng.,Cao, Qingjiu.,...&Wang, Yufeng.(2009).Altered Small-World Brain Functional Networks in Children With Attention-Deficit/Hyperactivity Disorder.HUMAN BRAIN MAPPING,30(2),638-649.
MLA Wang, Liang,et al."Altered Small-World Brain Functional Networks in Children With Attention-Deficit/Hyperactivity Disorder".HUMAN BRAIN MAPPING 30.2(2009):638-649.
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