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Pathological characteristics of the different stages of Acanthamoeba keratitis
Sun, Yuzhao1; Hong, Jing2; Zhang, Pei2; Peng, Rongmei2; Xiao, Gege2
关键词Acanthamoeba Keratitis Clinical Stage Pathological Features
刊名HISTOPATHOLOGY
2013-12-01
DOI10.1111/his.12237
63期:6页:862-868
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology ; Pathology
研究领域[WOS]Cell Biology ; Pathology
关键词[WOS]PATHOGENESIS ; MANNOSE ; CASTELLANII
英文摘要

AimsTo classify the clinical stages of Acanthamoeba keratitis (AK), and clarify the relationship between pathological changes and clinical features.

Methods and resultsBetween January 2007 and May 2012, AK was diagnosed in 11 eyes by pathological examination and confocal laser scanning microscopy. Pathological investigation of all cornea samples from keratoplasty was done with periodic acid-Schiff and haematoxylin and eosin stains. AK clinical stage, pathological features and postoperative treatment were studied retrospectively. The 11 cases were classified into development stage, convalescence stage, or cicatricial stage. In the development stage, marked conjunctival hyperaemia, a corneal epithelial defect, obvious corneal infiltration and progressive inflammation were seen; pathological changes comprised abundant inflammatory cells and a rounded cyst in the oedematous stroma, as well as a very small amount of neovascularization. In the convalescence cases, moderate conjunctival hyperaemia, corneal disciform structures, repair of the corneal epithelial defect and abundant neovascularization were seen; pathological changes included significant tissue necrosis and a small, shrunken cyst in the stroma, as well as significant neovascularization. In the cicatricial stage, keratoleukoma was seen; pathological changes comprised a few inflammatory cells and shrunken cysts scattered in the stroma. There were no cases of recurrence.

ConclusionsThe pathological features of different clinical stages confirmed the new clinical classification of AK.

语种英语
WOS记录号WOS:000327018300013
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54084
专题北京大学第三临床医学院
北京大学第三临床医学院_眼科
作者单位1.China Med Univ, Dept Ophthalmol, Affiliated Hosp 1, Shenyang, Peoples R China
2.Peking Univ Eye Ctr, Peking Univ Hosp 3, Beijing 100191, Peoples R China
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GB/T 7714
Sun, Yuzhao,Hong, Jing,Zhang, Pei,et al. Pathological characteristics of the different stages of Acanthamoeba keratitis[J]. HISTOPATHOLOGY,2013,63(6):862-868.
APA Sun, Yuzhao,Hong, Jing,Zhang, Pei,Peng, Rongmei,&Xiao, Gege.(2013).Pathological characteristics of the different stages of Acanthamoeba keratitis.HISTOPATHOLOGY,63(6),862-868.
MLA Sun, Yuzhao,et al."Pathological characteristics of the different stages of Acanthamoeba keratitis".HISTOPATHOLOGY 63.6(2013):862-868.
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