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学科主题: 基础医学
题名:
Hepatitis B virus basal core promoter mutations A1762T/G1764A are associated with genotype C and a low serum HBsAg level in chronically-infected HBeAg-positive Chinese patients
作者: Yan, Chun-Hui; Zhao, Cheng-Yu; Ding, Hai; Peng, Ya-Qin; Jin, Peng-Yuan; Yan, Ling; Zhuang, Hui1; Li, Tong
关键词: Hepatitis B virus ; A1762T/G1764A ; G1896A ; HBeAg-positive ; Mutation
刊名: ANTIVIRAL RESEARCH
发表日期: 2012-11-01
DOI: 10.1016/j.antiviral.2012.08.009
卷: 96, 期:2, 页:108-114
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy ; Virology
研究领域[WOS]: Pharmacology & Pharmacy ; Virology
关键词[WOS]: ANTIVIRAL RESISTANCE MUTATIONS ; E-ANTIGEN SEROCONVERSION ; CHRONIC LIVER-FAILURE ; PRECORE MUTATIONS ; NATURAL-HISTORY ; HEPATOCELLULAR-CARCINOMA ; REVERSE-TRANSCRIPTASE ; CLINICAL-SIGNIFICANCE ; VIRAL REPLICATION ; SURFACE-ANTIGEN
英文摘要:

The present study was aimed to obtain baseline information of basal core promoter A1762T/G1764A and precore G1896A mutations of hepatitis B virus (HBV) in 192 HBeAg-positive chronically-infected Chinese patients, who were potential candidates for antiviral treatment. The detection of these mutations (including minor mutant subpopulations) was achieved by direct sequencing, whose sensitivity for minor mutant subpopulations identification was confirmed by clone sequencing. Patients enrolled were infected with either genotype B (46.35%) or C (53.65%) HBV identified by routine tests in our laboratory. The A1762T/G1764A or G1896A mutations were detected in 125 specimens (125/192, 65.10%), in which 77 (77/125, 61.60%) existed as subpopulations. The A1762T/G1764A mutations were found to be more prevalent in genotype C than that in genotype B HBV [62.14% (64/103) vs. 20.22% (18/89), P<0.0001]. There is no statistically significant link between G1896A and genotypes. The emergence of A1762T/G1764A mutations was also found to be associated with an older age, an elevated ALT/AST level, and a lower HBsAg level in serum [wild-type vs. mutant: 4.57 (3.46-5.42) vs. 3.93 (2.51-5.36), P<0.0001]. In conclusion, HBV basal core promoter mutations A1762T/G1764A are associated with genotype C and a low serum HBsAg level in chronically-infected HBeAg-positive Chinese patients. (C) 2012 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 2008ZX10002-004 ; 2012ZX10002003
项目资助者: Grants of Major Science and Technology Special Project of China Eleventh Five-year Plan ; Major Science and Technology Special Project of China Twelfth Five-year Plan
WOS记录号: WOS:000313393800004
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54093
Appears in Collections:基础医学院_病原生物学系_期刊论文

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作者单位: 1.Peking Univ, Sch Basic Med Sci, Dept Microbiol, Beijing 100191, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Ctr Infect Dis, Beijing 100191, Peoples R China

Recommended Citation:
Yan, Chun-Hui,Zhao, Cheng-Yu,Ding, Hai,et al. Hepatitis B virus basal core promoter mutations A1762T/G1764A are associated with genotype C and a low serum HBsAg level in chronically-infected HBeAg-positive Chinese patients[J]. ANTIVIRAL RESEARCH,2012,96(2):108-114.
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