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Hepatitis B virus basal core promoter mutations A1762T/G1764A are associated with genotype C and a low serum HBsAg level in chronically-infected HBeAg-positive Chinese patients
Yan, Chun-Hui; Zhao, Cheng-Yu; Ding, Hai; Peng, Ya-Qin; Jin, Peng-Yuan; Yan, Ling; Zhuang, Hui1; Li, Tong
关键词Hepatitis B virus A1762T/G1764A G1896A HBeAg-positive Mutation
刊名ANTIVIRAL RESEARCH
2012-11-01
DOI10.1016/j.antiviral.2012.08.009
96期:2页:108-114
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy ; Virology
研究领域[WOS]Pharmacology & Pharmacy ; Virology
关键词[WOS]ANTIVIRAL RESISTANCE MUTATIONS ; E-ANTIGEN SEROCONVERSION ; CHRONIC LIVER-FAILURE ; PRECORE MUTATIONS ; NATURAL-HISTORY ; HEPATOCELLULAR-CARCINOMA ; REVERSE-TRANSCRIPTASE ; CLINICAL-SIGNIFICANCE ; VIRAL REPLICATION ; SURFACE-ANTIGEN
英文摘要

The present study was aimed to obtain baseline information of basal core promoter A1762T/G1764A and precore G1896A mutations of hepatitis B virus (HBV) in 192 HBeAg-positive chronically-infected Chinese patients, who were potential candidates for antiviral treatment. The detection of these mutations (including minor mutant subpopulations) was achieved by direct sequencing, whose sensitivity for minor mutant subpopulations identification was confirmed by clone sequencing. Patients enrolled were infected with either genotype B (46.35%) or C (53.65%) HBV identified by routine tests in our laboratory. The A1762T/G1764A or G1896A mutations were detected in 125 specimens (125/192, 65.10%), in which 77 (77/125, 61.60%) existed as subpopulations. The A1762T/G1764A mutations were found to be more prevalent in genotype C than that in genotype B HBV [62.14% (64/103) vs. 20.22% (18/89), P<0.0001]. There is no statistically significant link between G1896A and genotypes. The emergence of A1762T/G1764A mutations was also found to be associated with an older age, an elevated ALT/AST level, and a lower HBsAg level in serum [wild-type vs. mutant: 4.57 (3.46-5.42) vs. 3.93 (2.51-5.36), P<0.0001]. In conclusion, HBV basal core promoter mutations A1762T/G1764A are associated with genotype C and a low serum HBsAg level in chronically-infected HBeAg-positive Chinese patients. (C) 2012 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000313393800004
项目编号2008ZX10002-004 ; 2012ZX10002003
资助机构Grants of Major Science and Technology Special Project of China Eleventh Five-year Plan ; Major Science and Technology Special Project of China Twelfth Five-year Plan
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被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54093
专题北京大学基础医学院_病原生物学系
北京大学基础医学院
作者单位1.Peking Univ, Sch Basic Med Sci, Dept Microbiol, Beijing 100191, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Ctr Infect Dis, Beijing 100191, Peoples R China
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Yan, Chun-Hui,Zhao, Cheng-Yu,Ding, Hai,et al. Hepatitis B virus basal core promoter mutations A1762T/G1764A are associated with genotype C and a low serum HBsAg level in chronically-infected HBeAg-positive Chinese patients[J]. ANTIVIRAL RESEARCH,2012,96(2):108-114.
APA Yan, Chun-Hui.,Zhao, Cheng-Yu.,Ding, Hai.,Peng, Ya-Qin.,Jin, Peng-Yuan.,...&Li, Tong.(2012).Hepatitis B virus basal core promoter mutations A1762T/G1764A are associated with genotype C and a low serum HBsAg level in chronically-infected HBeAg-positive Chinese patients.ANTIVIRAL RESEARCH,96(2),108-114.
MLA Yan, Chun-Hui,et al."Hepatitis B virus basal core promoter mutations A1762T/G1764A are associated with genotype C and a low serum HBsAg level in chronically-infected HBeAg-positive Chinese patients".ANTIVIRAL RESEARCH 96.2(2012):108-114.
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