|Do Young Patients with Colorectal Cancer Have a Poorer Prognosis than Old Patients?|
|Li, Ming1; Li, Ji-You1,2; Zhao, Ai-Lian2; Gu, Jin1|
|关键词||Colorectal Cancer Young Prognosisp Cea Mmp-2 P27(Kip1)|
|刊名||JOURNAL OF SURGICAL RESEARCH|
|WOS标题词||Science & Technology|
|关键词[WOS]||CARCINOEMBRYONIC ANTIGEN ; LARGE-BOWEL ; COLON-CARCINOMA ; PATIENTS LESS ; AGE ; TISSUE ; ADENOCARCINOMA ; EXPRESSION ; SURVIVAL ; DECADES|
Background. Colorectal cancer (CRC) is generally a disease of the older population. The prognosis and clinicopathologic features of CRC in the young, compared with those in older patients, continue to be debated. The aim of this study was to compare the survival, clinicopathologic features, and tumor markers of CRC in patients aged 40 y or younger and older patients.
Methods. A total of 230 patientswithCRCof stage I-III were assessed retrospectively, with an endpoint of recurrence or metastasis after curative operation. The markersCEA, MMP-2, and p27(kip1) were studied by immunohistochemistry in all patients.
Results. The young group comprised 28 (12.2%) patients aged 40 y or younger with a median age of 36 y. The remaining 202 patients (87.8%) comprised the old group, with a median age of 61 y. There were no statistical differences in gender distribution, tumor sites, tumor size, or gross type between the young and old groups. The young group had a higher incidence of mucinous adenocarcinoma (17.9%) than the old group (6.4%) (P = 0.035). The distribution of stage, differentiation grade, and extent of venous invasion were similar. The median disease-free survival time was 60 mo for the young group and 49 mo for the old. Univariate analysis revealed that this difference was not significant (P = 0.1158). Multivariate Cox regression analysis also demonstrated that the age of the patient was not an independent factor for the prognosis of CRC. There were no statistical differences between the young and old groups in the expression of CEA, MMP-2, or p27(kip1).
Conclusions. The results of this study indicated that there was a subtle difference in the incidence of mucinous adenocarcinoma between young and old patients with CRC. However, stage I-III young patients had a similar disease-free survival period as the older patients. Other clinicopathologic characteristics, and tumor markers such as CEA, MMP-2, and p27(kip1), were also similar between young and old CRC patients. (C) 2011 Elsevier Inc. All rights reserved.
|资助机构||Beijing New Star Project on Science and Technology|
|作者单位||1.Peking Univ, Gastrointestinal Surg Dept, Sch Oncol,Key Lab Carcinogenesis & Translat Res, Beijing Canc Hosp & Inst,Minist Educ, Beijing 100036, Peoples R China|
2.Peking Univ, Dept Pathol, Sch Oncol,Key Lab Carcinogenesis & Translat Res, Beijing Canc Hosp & Inst,Minist Educ, Beijing 100036, Peoples R China
|Li, Ming,Li, Ji-You,Zhao, Ai-Lian,et al. Do Young Patients with Colorectal Cancer Have a Poorer Prognosis than Old Patients?[J]. JOURNAL OF SURGICAL RESEARCH,2011,167(2):231-236.|
|APA||Li, Ming,Li, Ji-You,Zhao, Ai-Lian,&Gu, Jin.(2011).Do Young Patients with Colorectal Cancer Have a Poorer Prognosis than Old Patients?.JOURNAL OF SURGICAL RESEARCH,167(2),231-236.|
|MLA||Li, Ming,et al."Do Young Patients with Colorectal Cancer Have a Poorer Prognosis than Old Patients?".JOURNAL OF SURGICAL RESEARCH 167.2(2011):231-236.|