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学科主题临床医学
Autophagy protects LNCaP cells under androgen deprivation conditions
Li, Mengqiang2; Jiang, Xuejun1; Liu, Di1; Na, Yanqun2; Gao, George F.1; Xi, Zhijun2
关键词Autophagy Prostatic Neoplasms Androgen Beclin 1 Apoptosis
刊名AUTOPHAGY
2008
4期:1页:54-60
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology
研究领域[WOS]Cell Biology
关键词[WOS]PROSTATE-CANCER CELLS ; RAT PROSTATE ; KINASE-B ; IN-VIVO ; APOPTOSIS ; GROWTH ; DEATH ; INHIBITION ; PROLIFERATION ; PROGRESSION
英文摘要

Androgen plays a critical role in the development and progression of prostate cancer. However, the regulatory role of androgen in the autophagic process and the function of the increased autophagosomes following androgen deprivation remain poorly understood. We found that autophagosomes, which were induced upon serum deprivation in LNCaP cells, can be significantly suppressed by dihydrotestosterone (DHT). Pharmacological inhibition of autophagy by 3-methyladenine led to increased apoptosis of LNCaP cells in serum-free medium compared to the medium with DHT or serum. Additionally, depletion of Beclin 1 to inhibit autophagy by small interfering RNA resulted in a slower proliferation of LNCaP cells in the medium depleted of serum than in the medium with DHT. Altogether, these findings suggested that LNCaP cells can resort to the autophagic pathway to survive under androgen deprivation conditions, which can be a novel mechanism involved in the transition of prostate cancer cells from an androgen-dependent to an androgen-independent cell type.

语种英语
WOS记录号WOS:000252211800007
引用统计
被引频次:57[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54103
专题北京大学第一临床医学院_泌尿外科
作者单位1.Chinese Acad Sci, Inst Microbiol, Ctr Mol Immunol, Beijing 100101, Peoples R China
2.Peking Univ, Peking Univ Hosp 1, Dept Urol, Inst Urol, Beijing 100871, Peoples R China
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GB/T 7714
Li, Mengqiang,Jiang, Xuejun,Liu, Di,et al. Autophagy protects LNCaP cells under androgen deprivation conditions[J]. AUTOPHAGY,2008,4(1):54-60.
APA Li, Mengqiang,Jiang, Xuejun,Liu, Di,Na, Yanqun,Gao, George F.,&Xi, Zhijun.(2008).Autophagy protects LNCaP cells under androgen deprivation conditions.AUTOPHAGY,4(1),54-60.
MLA Li, Mengqiang,et al."Autophagy protects LNCaP cells under androgen deprivation conditions".AUTOPHAGY 4.1(2008):54-60.
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