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学科主题: 临床医学
题名:
Brain areas that influence general anesthesia
作者: Leung, L. Stan1; Luo, Tao2; Ma, Jingyi1; Herrick, Ian3
关键词: Sleep-wake system ; Limbic system ; Loss of righting reflex ; Cortical activation ; Medial septum ; Hippocampus
刊名: PROGRESS IN NEUROBIOLOGY
发表日期: 2014-11-01
DOI: 10.1016/j.pneurobio.2014.08.001
卷: 122, 页:24-44
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: VENTROLATERAL PREOPTIC NUCLEUS ; BASAL FOREBRAIN NEURONS ; LOCUS-COERULEUS NEURONS ; PROPOFOL-INDUCED LOSS ; CEREBRAL-BLOOD-FLOW ; HISTAMINERGIC TUBEROMAMMILLARY NEURONS ; PEDUNCULOPONTINE TEGMENTAL NUCLEUS ; ALPHA-2 ADRENERGIC-RECEPTOR ; PONTINE RETICULAR-FORMATION ; PERIAQUEDUCTAL GRAY-MATTER
英文摘要:

This document reviews the literature on local brain manipulation of general anesthesia in animals, focusing on behavioral and electrographic effects related to hypnosis or loss of consciousness. Local inactivation or lesion of wake-active areas, such as locus coeruleus, dorsal raphe, pedunculopontine tegmental nucleus, perifornical area, tuberomammillary nucleus, ventral tegmental area and basal forebrain, enhanced general anesthesia. Anesthesia enhancement was shown as a delayed emergence (recovery of righting reflex) from anesthesia or a decrease in the minimal alveolar concentration that induced loss of righting. Local activation of various wake-active areas, including pontis oralis and centromedial thalamus, promoted behavioral or electrographic arousal during maintained anesthesia and facilitated emergence. Lesion of the sleep-active ventrolateral preoptic area resulted in increased wakefulness and decreased isoflurane sensitivity, but only for 6 days after lesion. Inactivation of any structure within limbic circuits involving the medial septum, hippocampus, nucleus accumbens, ventral pallidum, and ventral tegmental area, amygdala, entorhinal and piriform cortex delayed emergence from anesthesia, and often reduced anesthetic-induced behavioral excitation. In summary, the concept that anesthesia works on the sleep-wake system has received strong support from studies that inactivated/lesioned or activated wake-active areas, and weak support from studies that lesioned sleep-active areas. In addition to the conventional wake-sleep areas, limbic structures such as the medial septum, hippocampus and prefrontal cortex are also involved in the behavioral response to general anesthesia. We suggest that hypnosis during general anesthesia may result from disrupting the wake-active neuronal activities in multiple areas and suppressing an atropine-resistant cortical activation associated with movements. (C) 2014 Elsevier Ltd. All rights reserved.

语种: 英语
项目资助者: Canadian Institutes of Health ; Natural Sciences and Engineering Research Council of Canada
WOS记录号: WOS:000344442800002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54104
Appears in Collections:北京大学深圳医院_麻醉科_期刊论文

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作者单位: 1.Univ Western Ontario, Dept Physiol & Pharmacol, London, ON N6A 5C1, Canada
2.Peking Univ, Shenzhen Hosp, Dept Anesthesiol, Beijing, Peoples R China
3.Univ Western Ontario, Dept Anaesthesiol & Perioperat Med, London, ON N6A 5C1, Canada

Recommended Citation:
Leung, L. Stan,Luo, Tao,Ma, Jingyi,et al. Brain areas that influence general anesthesia[J]. PROGRESS IN NEUROBIOLOGY,2014,122:24-44.
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