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学科主题: 临床医学
题名:
Combination of F-18-fluorodeoxyglucose positron emission tomography/computed tomography and magnetic resonance imaging is an optimal way to evaluate rheumatoid arthritis in rats dynamically
作者: Zhang Wei-tao; Du Xiang-ke; Huo Tian-long; Wei Zheng-mao; Hao Chuan-xi; An Bei
关键词: F-18-fluorodeoxyglucose ; positron emission tomography/computed tomography ; magnetic resonance imaging ; rheumatoid arthritis
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2013-10-05
DOI: 10.3760/cma.j.issn.0366-6999.20130726
卷: 126, 期:19, 页:3732-3738
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: COLLAGEN-INDUCED ARTHRITIS ; ADJUVANT-INDUCED ARTHRITIS ; DISEASE-MODIFYING ACTIVITY ; MODEL ; MRI ; 7T
英文摘要:

Background Rheumatoid arthritis (RA) is a chronic, systemic autoimmune inflammatory disorder. Many methods have been used to observe the progress of RA. The purpose of this study was to observe the progress of RA in rats with F-18-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT), magnetic resonance (MR) imaging and arthritis score, and analyze the relationships among different methods in evaluation of RA.

Methods Sixteen healthy Sprague Dawley (SD) rats about 8-week old were randomly assigned to a RA group and a control group. Bovine type II emulsified incomplete Freud′s adjuvant was used to induce arthritis in the RA group. Arthritis score of the rats in two groups were recorded, and F-18-FDG PET/CT, MR imaging were performed both on the corresponding rats every 3 days. All the rats were sacrificed at week 5, and histopathological examination was performed on rat knees stained with haematoxylin and eosin.

Results The arthritis score and the standard uptake value (SUV) of knee joints in RA rats increased with the progression of arthritis gradually. Both peaks of arthritis score and SUV appeared at 21 days after the first immune injection, then the arthritis score and SUV of knee joints decreased slowly. The arthritis scores of knee joints in RA rats were positively correlated with their SUV changes. The MR images were confirmed by the histopathological studies.

Conclusion PET/CT can detect the earliest molecular metabolism changes of RA, and MR imaging can follow up the dynamical anatomical changes of RA, all of which indicated that PET/CT and MR imaging may be applied as useful tools to monitor the progress of RA.

语种: 英语
所属项目编号: 81071203
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000326426800025
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54107
Appears in Collections:北京大学第二临床医学院_放射科_期刊论文

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作者单位: Peking Univ Peoples Hosp, Dept Radiol, Beijing 100044, Peoples R China

Recommended Citation:
Zhang Wei-tao,Du Xiang-ke,Huo Tian-long,et al. Combination of F-18-fluorodeoxyglucose positron emission tomography/computed tomography and magnetic resonance imaging is an optimal way to evaluate rheumatoid arthritis in rats dynamically[J]. CHINESE MEDICAL JOURNAL,2013,126(19):3732-3738.
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