IR@PKUHSC  > 北京大学第二临床医学院  > 消化科
学科主题临床医学
Dysbiosis of Fungal Microbiota in the Intestinal Mucosa of Patients with Colorectal Adenomas
Luan, Chunguang1,2,3; Xie, Lingling4; Yang, Xi1,2,3; Miao, Huifang5,6; Lv, Na1,2; Zhang, Ruifen1,2; Xiao, Xue1,2; Hu, Yongfei1,2; Liu, Yulan4; Wu, Na4; Zhu, Yuanmin4; Zhu, Baoli1,2,7
刊名SCIENTIFIC REPORTS
2015-01-23
DOI10.1038/srep07980
5
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]16S RIBOSOMAL-RNA ; GUT MICROBIOTA ; MOLECULAR-IDENTIFICATION ; TRANSPLANT RECIPIENT ; RISK-FACTORS ; CANCER ; INFECTION ; DIVERSITY ; DISEASES ; PERITONITIS
英文摘要

The fungal microbiota is an important component of the human gut microbiome and may be linked to gastrointestinal disease. In this study, the fungal microbiota of biopsy samples from adenomas and adjacent tissues was characterized by deep sequencing. Ascomycota, Glomeromycota and Basidiomycota were identified as the dominant phyla in both adenomas and adjacent tissues from all subjects. Among the 60 genera identified, the opportunist pathogens Phoma and Candida represented an average of 45% of the fungal microbiota. When analyzed at the operational taxonomic unit (OTU) level, however, a decreased diversity in adenomas was observed, and three OTUs differed significantly from the adjacent tissues. Principal Component Analysis (PCA) revealed that the core OTUs formed separate clusters for advanced and non-advanced adenomas for which the abundance of four OTUs differed significantly. Moreover, the size of adenomas and the disease stage were closely related to changes in the fungal microbiota in subjects with adenomas. This study characterized the fungal microbiota profile of subjects with adenomas and identified potential diagnostic biomarkers closely related to different stages of adenomas.

语种英语
WOS记录号WOS:000348287500001
Citation statistics
Cited Times:21[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54109
Collection北京大学第二临床医学院_消化科
作者单位1.SinoGenoMax Co Ltd, Beijing 100176, Peoples R China
2.Chinese Natl Human Genome Ctr, Beijing 100176, Peoples R China
3.Chinese Acad Sci, Inst Microbiol, CAS Key Lab Pathogen Microbiol & Immunol, Beijing 100101, Peoples R China
4.Beijing Key Lab Microbial Drug Resistance & Resis, Beijing 100101, Peoples R China
5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
6.Peking Univ, Peoples Hosp, Dept Gastroenterol, Beijing 100044, Peoples R China
7.Zhejiang Univ, Coll Med, Affiliated Hosp 1, Collaborat Innovat Ctr Diag & Treatment Infect Di, Hangzhou 310006, Zhejiang, Peoples R China
Recommended Citation
GB/T 7714
Luan, Chunguang,Xie, Lingling,Yang, Xi,et al. Dysbiosis of Fungal Microbiota in the Intestinal Mucosa of Patients with Colorectal Adenomas[J]. SCIENTIFIC REPORTS,2015,5.
APA Luan, Chunguang.,Xie, Lingling.,Yang, Xi.,Miao, Huifang.,Lv, Na.,...&Zhu, Baoli.(2015).Dysbiosis of Fungal Microbiota in the Intestinal Mucosa of Patients with Colorectal Adenomas.SCIENTIFIC REPORTS,5.
MLA Luan, Chunguang,et al."Dysbiosis of Fungal Microbiota in the Intestinal Mucosa of Patients with Colorectal Adenomas".SCIENTIFIC REPORTS 5(2015).
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