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学科主题: 基础医学
题名:
Ectopic expression of a microbial-type rhodopsin restores visual responses in mice with photoreceptor degeneration
作者: Bi, AD; Cui, JJ; Ma, YP; Olshevskaya, E; Pu, ML; Dizhoor, AM; Pan, ZH
刊名: NEURON
发表日期: 2006-04-06
DOI: 10.1016/j.neuron.2006.02.026
卷: 50, 期:1, 页:23-33
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: RECOMBINANT ADENOASSOCIATED VIRUS ; RETINAL GANGLION-CELLS ; RETINITIS-PIGMENTOSA ; GENE-THERAPY ; GREEN-ALGAE ; TRANSGENE EXPRESSION ; BIPOLAR CELLS ; BETA-SUBUNIT ; MODEL ; LIGHT
英文摘要:

The death of photoreceptor cells caused by retinal degenerative diseases often results in a complete loss of retinal responses to light. We explore the feasibility of converting inner retinal neurons to photosensitive cells as a possible strategy for imparting light sensitivity to retinas lacking rods and cones. Using delivery by an adeno-associated viral vector, here, we show that long-term expression of a microbial-type rhodopsin, channelrhodopsin-2 (ChR2), can be achieved in rodent inner retinal neurons in vivo. Furthermore, we demonstrate that expression of ChR2 in surviving inner retinal neurons of a mouse with photoreceptor degeneration can restore the ability of the retina to encode light signals and transmit the light signals to the visual cortex. Thus, expression of microbial-type channelrhodopsins, such as ChR2, in surviving inner retinal neurons is a potential strategy for the restoration of vision after rod and cone degeneration.

语种: 英语
WOS记录号: WOS:000236811300008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54114
Appears in Collections:基础医学院_期刊论文

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作者单位: 1.Penn Coll Optometry, Elkins Pk, PA 19027 USA
2.Wayne State Univ, Sch Med, Dept Anat & Cell Biol, Detroit, MI 48201 USA
3.Peking Univ, Sch Basic Med Sci, Dept Anat & Embryol, Beijing 100083, Peoples R China

Recommended Citation:
Bi, AD,Cui, JJ,Ma, YP,et al. Ectopic expression of a microbial-type rhodopsin restores visual responses in mice with photoreceptor degeneration[J]. NEURON,2006,50(1):23-33.
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