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Ectopic expression of a microbial-type rhodopsin restores visual responses in mice with photoreceptor degeneration
Bi, AD; Cui, JJ; Ma, YP; Olshevskaya, E; Pu, ML; Dizhoor, AM; Pan, ZH
刊名NEURON
2006-04-06
DOI10.1016/j.neuron.2006.02.026
50期:1页:23-33
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]RECOMBINANT ADENOASSOCIATED VIRUS ; RETINAL GANGLION-CELLS ; RETINITIS-PIGMENTOSA ; GENE-THERAPY ; GREEN-ALGAE ; TRANSGENE EXPRESSION ; BIPOLAR CELLS ; BETA-SUBUNIT ; MODEL ; LIGHT
英文摘要

The death of photoreceptor cells caused by retinal degenerative diseases often results in a complete loss of retinal responses to light. We explore the feasibility of converting inner retinal neurons to photosensitive cells as a possible strategy for imparting light sensitivity to retinas lacking rods and cones. Using delivery by an adeno-associated viral vector, here, we show that long-term expression of a microbial-type rhodopsin, channelrhodopsin-2 (ChR2), can be achieved in rodent inner retinal neurons in vivo. Furthermore, we demonstrate that expression of ChR2 in surviving inner retinal neurons of a mouse with photoreceptor degeneration can restore the ability of the retina to encode light signals and transmit the light signals to the visual cortex. Thus, expression of microbial-type channelrhodopsins, such as ChR2, in surviving inner retinal neurons is a potential strategy for the restoration of vision after rod and cone degeneration.

语种英语
WOS记录号WOS:000236811300008
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被引频次:332[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54114
专题基础医学院
作者单位1.Penn Coll Optometry, Elkins Pk, PA 19027 USA
2.Wayne State Univ, Sch Med, Dept Anat & Cell Biol, Detroit, MI 48201 USA
3.Peking Univ, Sch Basic Med Sci, Dept Anat & Embryol, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Bi, AD,Cui, JJ,Ma, YP,et al. Ectopic expression of a microbial-type rhodopsin restores visual responses in mice with photoreceptor degeneration[J]. NEURON,2006,50(1):23-33.
APA Bi, AD.,Cui, JJ.,Ma, YP.,Olshevskaya, E.,Pu, ML.,...&Pan, ZH.(2006).Ectopic expression of a microbial-type rhodopsin restores visual responses in mice with photoreceptor degeneration.NEURON,50(1),23-33.
MLA Bi, AD,et al."Ectopic expression of a microbial-type rhodopsin restores visual responses in mice with photoreceptor degeneration".NEURON 50.1(2006):23-33.
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