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Effect of circulating tumor cells combined with negative enrichment and CD45-FISH identification in diagnosis, therapy monitoring and prognosis of primary lung cancer
Chen, Yang-Yang; Xu, Guo-Bin
关键词Primary Lung Cancer Ctcs Cd45-fish Diagnosis Treatment Monitoring Prognosis
刊名MEDICAL ONCOLOGY
2014-12-01
DOI10.1007/s12032-014-0240-0
31期:12
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]IN-SITU HYBRIDIZATION ; PERIPHERAL-BLOOD ; BREAST-CANCER ; IMPACT
英文摘要

Circulating tumor cells (CTCs) are valuable for diagnosis, monitoring therapy and prognosis in primary lung cancer. Herein, we evaluated the clinical significance of lung cancer CTCs in this study. Detection of CTCs was performed using epithelial cell adhesion molecule-independent enrichment and CD45 fluorescence in situ hybridization detection. CTCs >= 2/3.2 mL were considered as positive. The positive rates in primary lung cancer, benign lung disease and healthy control groups were 84, 0 and 4.2 %. CTCs count was significantly higher in lung cancer patients than healthy controls and benign lung disease, with an area under ROC curve of 0.917 (95 % confidence interval 0.855-0.979; p = 0.000) between lung cancer and nonmalignant diseases. CTCs count significantly increased with an increase in pathological stage with mean count of 2.3 +/- 2.6 (stage I-II), 3.5 +/- 3.3 (stage III) and 4.5 +/- 4.3 (stage IV), respectively. The positive detection rate of CTCs for primary lung cancer diagnosis was higher than serum tumor markers. In total, 25 metastasis lung cancer patients participated in the follow-up. Changes in CTCs count after two cycles of chemotherapy were consistent with radiographic appearance. Moreover, CTCs count was better than serum tumor markers for monitoring chemotherapy response. Median progression-free survival (PFS) was 2.05, 3.25 and 8.348 months (p < 0.05) in group in which post-treatment CTCs count was increased, unchanged and decreased, respectively. Furthermore, PFS in patients whose post-treatment CTCs count increased or were unchanged accompanied by a baseline CTCs count <3 was significantly shorter than those whose post-treatment CTCs count decreased or was unchanged accompanied with baseline value C3 (1.85 vs. 8.22 months, p = 0.000). Therefore, CTCs are a reproducible indicator of disease status that may be superior to imaging.

语种英语
WOS记录号WOS:000344531800003
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54119
专题北京大学第一临床医学院
作者单位Peking Univ, Hosp 1, Dept Clin Lab, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Chen, Yang-Yang,Xu, Guo-Bin. Effect of circulating tumor cells combined with negative enrichment and CD45-FISH identification in diagnosis, therapy monitoring and prognosis of primary lung cancer[J]. MEDICAL ONCOLOGY,2014,31(12).
APA Chen, Yang-Yang,&Xu, Guo-Bin.(2014).Effect of circulating tumor cells combined with negative enrichment and CD45-FISH identification in diagnosis, therapy monitoring and prognosis of primary lung cancer.MEDICAL ONCOLOGY,31(12).
MLA Chen, Yang-Yang,et al."Effect of circulating tumor cells combined with negative enrichment and CD45-FISH identification in diagnosis, therapy monitoring and prognosis of primary lung cancer".MEDICAL ONCOLOGY 31.12(2014).
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