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学科主题: 精神卫生
题名:
Expressions of Neuregulin 1 beta and ErbB4 in Prefrontal Cortex and Hippocampus of a Rat Schizophrenia Model Induced by Chronic MK-801 Administration
作者: Feng, Yu1; Wang, Xiao-Dong1,2; Guo, Chun-Mei1; Yang, Yang1; Li, Ji-Tao1; Su, Yun-Ai1; Si, Tian-Mei1
刊名: JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY
发表日期: 2010
DOI: 10.1155/2010/859516
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biotechnology & Applied Microbiology ; Medicine, Research & Experimental
研究领域[WOS]: Biotechnology & Applied Microbiology ; Research & Experimental Medicine
关键词[WOS]: NMDA RECEPTOR HYPOFUNCTION ; NERVOUS-SYSTEM ; SIGNALING PATHWAYS ; GENES ; BRAIN ; SUSCEPTIBILITY ; SYNAPSES ; DISEASE ; GROWTH
英文摘要:

Recent human genetic studies and postmortem brain examinations of schizophrenia patients strongly indicate that dysregulation of NRG1 and ErbB4 may be important pathogenic factors of schizophrenia. However, this hypothesis has not been validated and fully investigated in animal models of schizophrenia. In this study we quantitatively examined NRG1 and ErbB4 protein expressions by immunohistochemistry and Western blot in the brain of a rat schizophrenia model induced by chronic administration of MK-801 (a noncompetitive NMDA receptor antagonist). Our data showed that NRG1 beta and ErbB4 expressions were significantly increased in the rat prefrontal cortex and hippocampus but in different subregions. These findings suggest that altered expressions of NRG1 and ErbB4 might be attributed to the schizophrenia. Further study in the role and mechanism of NRG1 and ErbB4 may lead to better understanding of the pathophysiology for this disorder.

语种: 英语
所属项目编号: 30770775 ; 30800361
项目资助者: National Natural Scientific Foundation of China
WOS记录号: WOS:000278499300001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54123
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Max Planck Inst Psychiat, D-80804 Munich, Germany
2.Peking Univ, Key Lab Mental Hlth, Natl Hlth Minist, Inst Mental Hlth, Beijing 100191, Peoples R China

Recommended Citation:
Feng, Yu,Wang, Xiao-Dong,Guo, Chun-Mei,et al. Expressions of Neuregulin 1 beta and ErbB4 in Prefrontal Cortex and Hippocampus of a Rat Schizophrenia Model Induced by Chronic MK-801 Administration[J]. JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY,2010.
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