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Expressions of Neuregulin 1 beta and ErbB4 in Prefrontal Cortex and Hippocampus of a Rat Schizophrenia Model Induced by Chronic MK-801 Administration
Feng, Yu1; Wang, Xiao-Dong1,2; Guo, Chun-Mei1; Yang, Yang1; Li, Ji-Tao1; Su, Yun-Ai1; Si, Tian-Mei1
刊名JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY
2010
DOI10.1155/2010/859516
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biotechnology & Applied Microbiology ; Medicine, Research & Experimental
研究领域[WOS]Biotechnology & Applied Microbiology ; Research & Experimental Medicine
关键词[WOS]NMDA RECEPTOR HYPOFUNCTION ; NERVOUS-SYSTEM ; SIGNALING PATHWAYS ; GENES ; BRAIN ; SUSCEPTIBILITY ; SYNAPSES ; DISEASE ; GROWTH
英文摘要

Recent human genetic studies and postmortem brain examinations of schizophrenia patients strongly indicate that dysregulation of NRG1 and ErbB4 may be important pathogenic factors of schizophrenia. However, this hypothesis has not been validated and fully investigated in animal models of schizophrenia. In this study we quantitatively examined NRG1 and ErbB4 protein expressions by immunohistochemistry and Western blot in the brain of a rat schizophrenia model induced by chronic administration of MK-801 (a noncompetitive NMDA receptor antagonist). Our data showed that NRG1 beta and ErbB4 expressions were significantly increased in the rat prefrontal cortex and hippocampus but in different subregions. These findings suggest that altered expressions of NRG1 and ErbB4 might be attributed to the schizophrenia. Further study in the role and mechanism of NRG1 and ErbB4 may lead to better understanding of the pathophysiology for this disorder.

语种英语
WOS记录号WOS:000278499300001
项目编号30770775 ; 30800361
资助机构National Natural Scientific Foundation of China
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54123
专题北京大学精神卫生研究所
作者单位1.Max Planck Inst Psychiat, D-80804 Munich, Germany
2.Peking Univ, Key Lab Mental Hlth, Natl Hlth Minist, Inst Mental Hlth, Beijing 100191, Peoples R China
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GB/T 7714
Feng, Yu,Wang, Xiao-Dong,Guo, Chun-Mei,et al. Expressions of Neuregulin 1 beta and ErbB4 in Prefrontal Cortex and Hippocampus of a Rat Schizophrenia Model Induced by Chronic MK-801 Administration[J]. JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY,2010.
APA Feng, Yu.,Wang, Xiao-Dong.,Guo, Chun-Mei.,Yang, Yang.,Li, Ji-Tao.,...&Si, Tian-Mei.(2010).Expressions of Neuregulin 1 beta and ErbB4 in Prefrontal Cortex and Hippocampus of a Rat Schizophrenia Model Induced by Chronic MK-801 Administration.JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY.
MLA Feng, Yu,et al."Expressions of Neuregulin 1 beta and ErbB4 in Prefrontal Cortex and Hippocampus of a Rat Schizophrenia Model Induced by Chronic MK-801 Administration".JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY (2010).
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