IR@PKUHSC  > 北京大学基础医学院  > 医学信息学系
学科主题医学信息学
The relationship between rational drug design and drug side effects
Wang, Juan; Li, Zhi-xin3; Qiu, Cheng-xiang; Wang, Dong; Cui, Qing-hua1,2
关键词Rational Drug Design Systems Pharmacology Network Distance Side Effects Sider
刊名BRIEFINGS IN BIOINFORMATICS
2012-05-01
DOI10.1093/bib/bbr061
13期:3页:377-382
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemical Research Methods ; Mathematical & Computational Biology
研究领域[WOS]Biochemistry & Molecular Biology ; Mathematical & Computational Biology
关键词[WOS]NETWORK ; RESOURCE
英文摘要

Previous analysis of systems pharmacology has revealed a tendency of rational drug design in the pharmaceutical industry. The targets of new drugs tend to be close with the corresponding disease genes in the biological networks. However, it remains unclear whether the rational drug design introduces disadvantages, i.e. side effects. Therefore, it is important to dissect the relationship between rational drug design and drug side effects. Based on a recently released drug side effect database, SIDER, here we analyzed the relationship between drug side effects and the rational drug design. We revealed that the incidence drug side effect is significantly associated with the network distance of drug targets and diseases genes. Drugs with the distances of three or four have the smallest incidence of side effects, whereas drugs with the distances of more than four or smaller than three show significantly greater incidence of side effects. Furthermore, protein drugs and small molecule drugs show significant differences. Drugs hitting membrane targets and drugs hitting cytoplasm targets also show differences. Failure drugs because of severe side effects show smaller network distances than approved drugs. These results suggest that researchers should be prudent on rationalizing the drug design. Too small distances between drug targets and diseases genes may not always be advantageous for rational design for drug discovery.

语种英语
WOS记录号WOS:000304536200010
项目编号81001481
资助机构National Natural Science Foundation of China
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54125
专题北京大学基础医学院_医学信息学系
北京大学基础医学院
作者单位1.Peking Univ, Dept Biomed Informat, Inst Syst Biomed, Hlth Sci Ctr, Beijing 100871, Peoples R China
2.Peking Univ, Computat Biol Grp, Inst Syst Biomed, Hlth Sci Ctr, Beijing 100871, Peoples R China
3.Peking Univ, Dept Integrated Chinese & Western Med, Hlth Sci Ctr, Beijing 100871, Peoples R China
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GB/T 7714
Wang, Juan,Li, Zhi-xin,Qiu, Cheng-xiang,et al. The relationship between rational drug design and drug side effects[J]. BRIEFINGS IN BIOINFORMATICS,2012,13(3):377-382.
APA Wang, Juan,Li, Zhi-xin,Qiu, Cheng-xiang,Wang, Dong,&Cui, Qing-hua.(2012).The relationship between rational drug design and drug side effects.BRIEFINGS IN BIOINFORMATICS,13(3),377-382.
MLA Wang, Juan,et al."The relationship between rational drug design and drug side effects".BRIEFINGS IN BIOINFORMATICS 13.3(2012):377-382.
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