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学科主题: 基础医学
题名:
Kindlin 2 forms a transcriptional complex with beta-catenin and TCF4 to enhance Wnt signalling
作者: Yu, Yu1,2; Wu, Junzhou1,2; Wang, Yunling1,3; Zhao, Ting1,4; Ma, Bo1,2; Liu, Yuqing1,2; Fang, Weigang1,4; Zhu, Wei-Guo1,5; Zhang, Hongquan1,2,3
关键词: beta-catenin ; protein complex ; Kindlins ; Wnt signalling
刊名: EMBO REPORTS
发表日期: 2012-08-01
DOI: 10.1038/embor.2012.88
卷: 13, 期:8, 页:750-758
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Cell Biology
研究领域[WOS]: Biochemistry & Molecular Biology ; Cell Biology
关键词[WOS]: MITOGEN-INDUCIBLE GENE-2 ; BREAST-CANCER ; CELL INVASION ; ADHESION ; EXPRESSION ; GROWTH
英文摘要:

Kindlin 2, as a focal adhesion protein, controls integrin activation. However, the association of Kindlin 2 with cancer-related signalling pathways is unknown. Here we identified a new direct interaction between Kindlin 2 and the active beta-catenin. Importantly, Kindlin 2 forms a tripartite complex with beta-catenin and TCF4. Mechanistically, Kindlin 2 selectively strengthens the occupancy of beta-catenin on the Wnt target gene Axin2 and enhances Axin2 gene expression. Functionally, the beta-catenin-Axin2-Snail cascade is required for Kindlin 2-induced tumour cell invasion. Our data indicate that Kindlin 2 is a new regulator of Wnt signalling, providing a mechanistic insight into the role of Kindlin 2 in cancer progression.

语种: 英语
所属项目编号: 30830048 ; 2010CB912203 ; 2010CB529402 ; 31170711 ; 81101495 ; 7120002
项目资助者: National Natural Science Foundation of China ; Ministry of Science and Technology of China ; NSFC ; Beijing Natural Science Foundation ; Swedish Cancer Foundation ; Swedish Research Council
WOS记录号: WOS:000307113300016
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54128
Appears in Collections:基础医学院_病理学系_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Minist Educ, Key Lab Carcinogenesis & Translat Res, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Anat Histol & Embryol, Beijing 100191, Peoples R China
3.Karolinska Inst, Dept Biosci & Nutr, Ctr Biosci, SE-14183 Huddinge, Sweden
4.Peking Univ, Hlth Sci Ctr, Dept Pathol, Beijing 100191, Peoples R China
5.Peking Univ, Hlth Sci Ctr, Dept Biochem & Mol Biol, Beijing 100191, Peoples R China

Recommended Citation:
Yu, Yu,Wu, Junzhou,Wang, Yunling,et al. Kindlin 2 forms a transcriptional complex with beta-catenin and TCF4 to enhance Wnt signalling[J]. EMBO REPORTS,2012,13(8):750-758.
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