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Multifunctional targeting daunorubicin plus quinacrine liposomes, modified by wheat germ agglutinin and tamoxifen, for treating brain glioma and glioma stem cells
Li, Xue-Tao1,2; Ju, Rui-Jun1; Li, Xiu-Ying1; Zeng, Fan1; Shi, Ji-Feng1; Liu, Lei1; Zhang, Cheng-Xiang1; Sun, Meng-Ge1; Lou, Jin-Ning3; Lu, Wan-Liang1
关键词Multifunctional Targeting Liposomes Wheat Germ Agglutinin Daunorubicin Tamoxifen Brain Glioma Stem Cells
刊名ONCOTARGET
2014-08-15
5期:15页:6497-6511
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Cell Biology
资助者National Basic Research Program of China (973 program) ; Beijing Natural Science Foundation ; National Science Foundation of China ; National Basic Research Program of China (973 program) ; Beijing Natural Science Foundation ; National Science Foundation of China
研究领域[WOS]Oncology ; Cell Biology
关键词[WOS]BREAST-CANCER ; DRUG TRANSPORT ; IN-VITRO ; BARRIER ; APOPTOSIS ; DELIVERY ; THERAPY ; CHEMOTHERAPY ; DOXORUBICIN ; PACLITAXEL
英文摘要

Most anticancer drugs are not able to cross the blood-brain barrier (BBB) effectively while surgery and radiation therapy cannot eradicate brain glioma cells and glioma stem cells (GSCs), hence resulting in poor prognosis with high recurrence rates. In the present study, a kind of multifunctional targeting daunorubicin plus quinacrine liposomes was developed for treating brain glioma and GSCs. Evaluations were performed on in-vitro BBB model, murine glioma cells, GSCs, and GSCs bearing mice. Results showed that the multifunctional targeting daunorubicin plus quinacrine liposomes exhibited evident capabilities in crossing the BBB, in killing glioma cells and GSCs and in diminishing brain glioma in mice. Action mechanism studies indicated that the enhanced efficacy of the multifunctional targeting drugs-loaded liposomes could be due to the following aspects: evading the rapid elimination from blood circulation; crossing the BBB effectively; improving drug uptake by glioma cells and GSCs; down-regulating the overexpressed ABC transporters; inducing apoptosis of GSCs via up-regulating apoptotic receptor/ligand (Fas/Fasl), activating apoptotic enzymes (caspases 8, 9 and 3), activating pro-apoptotic proteins (Bax and Bok), activating tumor suppressor protein (P53) and suppressing anti-apoptotic proteins (Bcl-2 and Mcl-1). In conclusion, the multifunctional targeting daunorubicin plus quinacrine liposomes could be used as a potential therapy for treating brain glioma and GSCs.

语种英语
所属项目编号2013CB932501 ; 7131009 ; 81172991 ; 81373343
资助者National Basic Research Program of China (973 program) ; Beijing Natural Science Foundation ; National Science Foundation of China ; National Basic Research Program of China (973 program) ; Beijing Natural Science Foundation ; National Science Foundation of China
WOS记录号WOS:000347919500051
引用统计
被引频次:18[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54137
专题北京大学药学院
作者单位1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100871, Peoples R China
2.Liaoning Univ Tradit Chinese Med, Sch Pharm, Dalian, Peoples R China
3.Chia Japan Friendship Hosp, Minist Hlth, Inst Clin Med Sci, Beijing, Peoples R China
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GB/T 7714
Li, Xue-Tao,Ju, Rui-Jun,Li, Xiu-Ying,et al. Multifunctional targeting daunorubicin plus quinacrine liposomes, modified by wheat germ agglutinin and tamoxifen, for treating brain glioma and glioma stem cells[J]. ONCOTARGET,2014,5(15):6497-6511.
APA Li, Xue-Tao.,Ju, Rui-Jun.,Li, Xiu-Ying.,Zeng, Fan.,Shi, Ji-Feng.,...&Lu, Wan-Liang.(2014).Multifunctional targeting daunorubicin plus quinacrine liposomes, modified by wheat germ agglutinin and tamoxifen, for treating brain glioma and glioma stem cells.ONCOTARGET,5(15),6497-6511.
MLA Li, Xue-Tao,et al."Multifunctional targeting daunorubicin plus quinacrine liposomes, modified by wheat germ agglutinin and tamoxifen, for treating brain glioma and glioma stem cells".ONCOTARGET 5.15(2014):6497-6511.
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