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学科主题: 药学
题名:
Multifunctional targeting daunorubicin plus quinacrine liposomes, modified by wheat germ agglutinin and tamoxifen, for treating brain glioma and glioma stem cells
作者: Li, Xue-Tao1,2; Ju, Rui-Jun1; Li, Xiu-Ying1; Zeng, Fan1; Shi, Ji-Feng1; Liu, Lei1; Zhang, Cheng-Xiang1; Sun, Meng-Ge1; Lou, Jin-Ning3; Lu, Wan-Liang1
关键词: multifunctional targeting liposomes ; wheat germ agglutinin ; daunorubicin ; tamoxifen ; brain glioma stem cells
刊名: ONCOTARGET
发表日期: 2014-08-15
卷: 5, 期:15, 页:6497-6511
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Cell Biology
研究领域[WOS]: Oncology ; Cell Biology
关键词[WOS]: BREAST-CANCER ; DRUG TRANSPORT ; IN-VITRO ; BARRIER ; APOPTOSIS ; DELIVERY ; THERAPY ; CHEMOTHERAPY ; DOXORUBICIN ; PACLITAXEL
英文摘要:

Most anticancer drugs are not able to cross the blood-brain barrier (BBB) effectively while surgery and radiation therapy cannot eradicate brain glioma cells and glioma stem cells (GSCs), hence resulting in poor prognosis with high recurrence rates. In the present study, a kind of multifunctional targeting daunorubicin plus quinacrine liposomes was developed for treating brain glioma and GSCs. Evaluations were performed on in-vitro BBB model, murine glioma cells, GSCs, and GSCs bearing mice. Results showed that the multifunctional targeting daunorubicin plus quinacrine liposomes exhibited evident capabilities in crossing the BBB, in killing glioma cells and GSCs and in diminishing brain glioma in mice. Action mechanism studies indicated that the enhanced efficacy of the multifunctional targeting drugs-loaded liposomes could be due to the following aspects: evading the rapid elimination from blood circulation; crossing the BBB effectively; improving drug uptake by glioma cells and GSCs; down-regulating the overexpressed ABC transporters; inducing apoptosis of GSCs via up-regulating apoptotic receptor/ligand (Fas/Fasl), activating apoptotic enzymes (caspases 8, 9 and 3), activating pro-apoptotic proteins (Bax and Bok), activating tumor suppressor protein (P53) and suppressing anti-apoptotic proteins (Bcl-2 and Mcl-1). In conclusion, the multifunctional targeting daunorubicin plus quinacrine liposomes could be used as a potential therapy for treating brain glioma and GSCs.

语种: 英语
所属项目编号: 2013CB932501 ; 7131009 ; 81172991 ; 81373343
项目资助者: National Basic Research Program of China (973 program) ; Beijing Natural Science Foundation ; National Science Foundation of China
WOS记录号: WOS:000347919500051
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54137
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100871, Peoples R China
2.Liaoning Univ Tradit Chinese Med, Sch Pharm, Dalian, Peoples R China
3.Chia Japan Friendship Hosp, Minist Hlth, Inst Clin Med Sci, Beijing, Peoples R China

Recommended Citation:
Li, Xue-Tao,Ju, Rui-Jun,Li, Xiu-Ying,et al. Multifunctional targeting daunorubicin plus quinacrine liposomes, modified by wheat germ agglutinin and tamoxifen, for treating brain glioma and glioma stem cells[J]. ONCOTARGET,2014,5(15):6497-6511.
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