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学科主题: 临床医学
题名:
The Expression and Significance Profile of TLR-2 in the Salivary Gland Tumor and Inflammation
作者: Sheng, Meng Yu1,3; Yu, Yang Hong1; Wu, Zheng Li2; Jun, Yang Hui1; Yue, Sheng Shi1; Yuan, Yang Yuan1,3; Feng, Wang1,3; Ping, Ma Ping1,3
关键词: TLR-2 ; salivary gland tumor ; salivary gland inflammation
刊名: JOURNAL OF PURE AND APPLIED MICROBIOLOGY
发表日期: 2013-04-01
卷: 7, 期:SI, 页:33-39
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biotechnology & Applied Microbiology ; Microbiology
研究领域[WOS]: Biotechnology & Applied Microbiology ; Microbiology
关键词[WOS]: TOLL-LIKE RECEPTOR-2 ; EPITHELIAL-CELLS ; HUMAN BETA-DEFENSIN-2 ; ACTIVATION ; CARCINOMA ; CYTOKINES
英文摘要:

This study was to research the different mRNA and protein expression of Toll-like receptors 2 (TLR-2) characteristics in saliary gland benign (SGBT), malignant tumor tissue (SGMT)and saliary gland inflammation (SGI) by the methods of PCR, qRT-PCR and immunohistochemisty. the results showed that, compared with normal tissues, the TLR-2 mRNA expression in salivary gland benign tumor, salivary gland cancer and inflammation tissues were amount to 6.628 fold, 0.432 fold and 8.583 fold respectively (p <0.05). Importantly, we also found that TLR-2 in these organizations not only has a say in the cytoplasm, and the nucleus has expressed only in the SGMT, which was instant differently previous research. This study suggests that there is an variation of TLR2 association between salivary gland tumor, inflammation and NSG. This finding supports a potential role in tumor development, and provide a foundation for development of immune modulation and chemotherapy for SGT.

语种: 英语
所属项目编号: 30973339 ; 2010BO 50100007 ; JC2011 05201030A ; ZYA201106100080A
项目资助者: National Nature Science Foundation ; Guangdong International Cooperation Projects Foundation ; Shenzhen Innovation Committee Basic Research Projects Foundation ; Shenzhen Innovation Committee International Projects Foundation
WOS记录号: WOS:000322682600006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54140
Appears in Collections:北京大学深圳医院_期刊论文

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作者单位: 1.Shantou Univ, Coll Med, Shantou, Peoples R China
2.Peking Univ, Shenzhen Hosp, Dept Oral & Maxillofacial Surg, Shenzhen 518036, Peoples R China
3.Univ Hong Kong, Fac Dent, Discipline Oral Diag & Polyclin, Hong Kong, Hong Kong, Peoples R China

Recommended Citation:
Sheng, Meng Yu,Yu, Yang Hong,Wu, Zheng Li,et al. The Expression and Significance Profile of TLR-2 in the Salivary Gland Tumor and Inflammation[J]. JOURNAL OF PURE AND APPLIED MICROBIOLOGY,2013,7(SI):33-39.
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