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学科主题临床医学
INTRAVITREAL BEVACIZUMAB FOR EXUDATIVE AGE-RELATED MACULAR DEGENERATION Effect on Different Subfoveal Membranes
Tao, Yong1,2; Jonas, Jost B.1
关键词Exudative Age-related Macular Degeneration Intravitreal Bevacizumab Avastin Intraocular Neovascularization
刊名RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
2010-10-01
DOI10.1097/IAE.0b013e3181d5e964
30期:9页:1426-1431
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Ophthalmology
研究领域[WOS]Ophthalmology
关键词[WOS]OCCULT CHOROIDAL NEOVASCULARIZATION ; PIGMENT EPITHELIAL DETACHMENT ; PHOTODYNAMIC THERAPY ; SUBGROUP ANALYSIS ; AVASTIN TREATMENT ; RANIBIZUMAB ; VERTEPORFIN ; SECONDARY ; ANCHOR
英文摘要

Purpose: The purpose of this study was to assess an association between specific types of subfoveal neovascularization and the change in visual acuity after intravitreal injections of bevacizumab (F. Hoffmann-La Roche AG, Basel, Switzerland) as treatment for exudative age-related macular degeneration.

Methods: This retrospective clinical interventional comparative study included 307 patients (378 eyes) who received 3 consecutive intravitreal injections of bevacizumab at intervals of 2 months each. The study group was divided into eyes with a predominantly or purely classic type of subfoveal neovascular membrane (n = 81), those with an occult type with or without minimally classic subfoveal neovascularization (n = 232), and eyes with a detachment of the retinal pigment epithelium (n = 65).

Results: The gain in best-corrected visual acuity did not vary significantly among the 3 subgroups at 2 months after baseline (P = 0.35 and P = 0.27), at 4 months after baseline (P = 0.63 and P = 0.56), or at the final follow-up at 7 months after baseline (P = 0.85 and P = 0.76). In multivariate linear regression analysis, the gain in best-corrected visual acuity at the final follow-up was significantly associated with the best-corrected visual acuity at baseline (P < 0.001). It was not significantly associated with age (P = 0.61), sex (P = 0.12), self-reported diabetes (P = 0.79), lens status (P = 0.84), or type of subfoveal neovascularization (P = 0.53).

Conclusion: After an intravitreal application of bevacizumab given as therapy for exudative age-related macular degeneration at 2-month intervals, the patient′s gain in visual acuity did not depend on the type of the subfoveal neovascular membranes. RETINA 30: 1426-1431, 2010

语种英语
WOS记录号WOS:000282561800011
资助机构German Academic Exchange Service (DAAD)
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54141
专题北京大学第二临床医学院_眼科
作者单位1.Univ Heidelberg, Med Fac Mannheim, Dept Ophthalmol, Heidelberg, Germany
2.Peking Univ, Dept Ophthalmol, Peoples Hosp, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Tao, Yong,Jonas, Jost B.. INTRAVITREAL BEVACIZUMAB FOR EXUDATIVE AGE-RELATED MACULAR DEGENERATION Effect on Different Subfoveal Membranes[J]. RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES,2010,30(9):1426-1431.
APA Tao, Yong,&Jonas, Jost B..(2010).INTRAVITREAL BEVACIZUMAB FOR EXUDATIVE AGE-RELATED MACULAR DEGENERATION Effect on Different Subfoveal Membranes.RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES,30(9),1426-1431.
MLA Tao, Yong,et al."INTRAVITREAL BEVACIZUMAB FOR EXUDATIVE AGE-RELATED MACULAR DEGENERATION Effect on Different Subfoveal Membranes".RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES 30.9(2010):1426-1431.
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