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学科主题: 临床医学
题名:
INTRAVITREAL BEVACIZUMAB FOR EXUDATIVE AGE-RELATED MACULAR DEGENERATION Effect on Different Subfoveal Membranes
作者: Tao, Yong1,2; Jonas, Jost B.1
关键词: exudative age-related macular degeneration ; intravitreal bevacizumab ; Avastin ; intraocular neovascularization
刊名: RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
发表日期: 2010-10-01
DOI: 10.1097/IAE.0b013e3181d5e964
卷: 30, 期:9, 页:1426-1431
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Ophthalmology
研究领域[WOS]: Ophthalmology
关键词[WOS]: OCCULT CHOROIDAL NEOVASCULARIZATION ; PIGMENT EPITHELIAL DETACHMENT ; PHOTODYNAMIC THERAPY ; SUBGROUP ANALYSIS ; AVASTIN TREATMENT ; RANIBIZUMAB ; VERTEPORFIN ; SECONDARY ; ANCHOR
英文摘要:

Purpose: The purpose of this study was to assess an association between specific types of subfoveal neovascularization and the change in visual acuity after intravitreal injections of bevacizumab (F. Hoffmann-La Roche AG, Basel, Switzerland) as treatment for exudative age-related macular degeneration.

Methods: This retrospective clinical interventional comparative study included 307 patients (378 eyes) who received 3 consecutive intravitreal injections of bevacizumab at intervals of 2 months each. The study group was divided into eyes with a predominantly or purely classic type of subfoveal neovascular membrane (n = 81), those with an occult type with or without minimally classic subfoveal neovascularization (n = 232), and eyes with a detachment of the retinal pigment epithelium (n = 65).

Results: The gain in best-corrected visual acuity did not vary significantly among the 3 subgroups at 2 months after baseline (P = 0.35 and P = 0.27), at 4 months after baseline (P = 0.63 and P = 0.56), or at the final follow-up at 7 months after baseline (P = 0.85 and P = 0.76). In multivariate linear regression analysis, the gain in best-corrected visual acuity at the final follow-up was significantly associated with the best-corrected visual acuity at baseline (P < 0.001). It was not significantly associated with age (P = 0.61), sex (P = 0.12), self-reported diabetes (P = 0.79), lens status (P = 0.84), or type of subfoveal neovascularization (P = 0.53).

Conclusion: After an intravitreal application of bevacizumab given as therapy for exudative age-related macular degeneration at 2-month intervals, the patient′s gain in visual acuity did not depend on the type of the subfoveal neovascular membranes. RETINA 30: 1426-1431, 2010

语种: 英语
项目资助者: German Academic Exchange Service (DAAD)
WOS记录号: WOS:000282561800011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54141
Appears in Collections:北京大学第二临床医学院_眼科_期刊论文

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作者单位: 1.Univ Heidelberg, Med Fac Mannheim, Dept Ophthalmol, Heidelberg, Germany
2.Peking Univ, Dept Ophthalmol, Peoples Hosp, Beijing 100871, Peoples R China

Recommended Citation:
Tao, Yong,Jonas, Jost B.. INTRAVITREAL BEVACIZUMAB FOR EXUDATIVE AGE-RELATED MACULAR DEGENERATION Effect on Different Subfoveal Membranes[J]. RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES,2010,30(9):1426-1431.
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