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学科主题: 药学
题名:
A solid-phase method for peptide-siRNA covalent conjugates based on click chemistry
作者: Liu, Yang; Wang, Xiao-Feng; Chen, Yue; Zhang, Li-He; Yang, Zhen-Jun
刊名: MEDCHEMCOMM
发表日期: 2012-04-01
DOI: 10.1039/c2md00198e
卷: 3, 期:4, 页:506-511
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Chemistry, Medicinal
研究领域[WOS]: Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
关键词[WOS]: IN-VIVO ; DELIVERY ; OLIGONUCLEOTIDES ; THERAPEUTICS ; PROGRESS ; CELLS
英文摘要:

In order to prepare a new delivery system by chemical modification, peptide-siRNA conjugates have been obtained by a solid-phase click chemistry strategy, using an alkynyl nucleoside analogue "clicked" onto a peptide-derivatized CPG (Controlled Pore Glass) followed by oligonucleotides synthesis. The 3′-sense strand conjugate maintained good gene silencing activity, while that of the 3′-antisense strand conjugate decreased somewhat.

语种: 英语
所属项目编号: 20932001 ; 2009ZX09503
项目资助者: National Natural Science Foundation of China ; Ministry of Science and Technology of China
WOS记录号: WOS:000303086200017
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54143
Appears in Collections:北京大学药学院_期刊论文

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作者单位: Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

Recommended Citation:
Liu, Yang,Wang, Xiao-Feng,Chen, Yue,et al. A solid-phase method for peptide-siRNA covalent conjugates based on click chemistry[J]. MEDCHEMCOMM,2012,3(4):506-511.
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