北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学药学院  > 期刊论文
学科主题: 药学
题名:
A solid-phase method for peptide-siRNA covalent conjugates based on click chemistry
作者: Liu, Yang; Wang, Xiao-Feng; Chen, Yue; Zhang, Li-He; Yang, Zhen-Jun
刊名: MEDCHEMCOMM
发表日期: 2012-04-01
DOI: 10.1039/c2md00198e
卷: 3, 期:4, 页:506-511
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Chemistry, Medicinal
研究领域[WOS]: Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
关键词[WOS]: IN-VIVO ; DELIVERY ; OLIGONUCLEOTIDES ; THERAPEUTICS ; PROGRESS ; CELLS
英文摘要:

In order to prepare a new delivery system by chemical modification, peptide-siRNA conjugates have been obtained by a solid-phase click chemistry strategy, using an alkynyl nucleoside analogue "clicked" onto a peptide-derivatized CPG (Controlled Pore Glass) followed by oligonucleotides synthesis. The 3′-sense strand conjugate maintained good gene silencing activity, while that of the 3′-antisense strand conjugate decreased somewhat.

语种: 英语
所属项目编号: 20932001 ; 2009ZX09503
项目资助者: National Natural Science Foundation of China ; Ministry of Science and Technology of China
WOS记录号: WOS:000303086200017
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54143
Appears in Collections:北京大学药学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

Recommended Citation:
Liu, Yang,Wang, Xiao-Feng,Chen, Yue,et al. A solid-phase method for peptide-siRNA covalent conjugates based on click chemistry[J]. MEDCHEMCOMM,2012,3(4):506-511.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Liu, Yang]'s Articles
[Wang, Xiao-Feng]'s Articles
[Chen, Yue]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Liu, Yang]‘s Articles
[Wang, Xiao-Feng]‘s Articles
[Chen, Yue]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace