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A solid-phase method for peptide-siRNA covalent conjugates based on click chemistry
Liu, Yang; Wang, Xiao-Feng; Chen, Yue; Zhang, Li-He; Yang, Zhen-Jun
刊名MEDCHEMCOMM
2012-04-01
DOI10.1039/c2md00198e
3期:4页:506-511
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Chemistry, Medicinal
资助者National Natural Science Foundation of China ; Ministry of Science and Technology of China ; National Natural Science Foundation of China ; Ministry of Science and Technology of China
研究领域[WOS]Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
关键词[WOS]IN-VIVO ; DELIVERY ; OLIGONUCLEOTIDES ; THERAPEUTICS ; PROGRESS ; CELLS
英文摘要

In order to prepare a new delivery system by chemical modification, peptide-siRNA conjugates have been obtained by a solid-phase click chemistry strategy, using an alkynyl nucleoside analogue "clicked" onto a peptide-derivatized CPG (Controlled Pore Glass) followed by oligonucleotides synthesis. The 3′-sense strand conjugate maintained good gene silencing activity, while that of the 3′-antisense strand conjugate decreased somewhat.

语种英语
所属项目编号20932001 ; 2009ZX09503
资助者National Natural Science Foundation of China ; Ministry of Science and Technology of China ; National Natural Science Foundation of China ; Ministry of Science and Technology of China
WOS记录号WOS:000303086200017
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54143
专题北京大学药学院
作者单位Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Liu, Yang,Wang, Xiao-Feng,Chen, Yue,et al. A solid-phase method for peptide-siRNA covalent conjugates based on click chemistry[J]. MEDCHEMCOMM,2012,3(4):506-511.
APA Liu, Yang,Wang, Xiao-Feng,Chen, Yue,Zhang, Li-He,&Yang, Zhen-Jun.(2012).A solid-phase method for peptide-siRNA covalent conjugates based on click chemistry.MEDCHEMCOMM,3(4),506-511.
MLA Liu, Yang,et al."A solid-phase method for peptide-siRNA covalent conjugates based on click chemistry".MEDCHEMCOMM 3.4(2012):506-511.
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