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Impaired single cell firing and long-term potentiation parallels memory impairment following recurrent seizures
Zhou, Jun-Li; Shatskikh, Tatiana N.; Liu, Xianzeng; Holmes, Gregory L.
关键词Eeg Epilepsy Interneurons Place Cells Seizures
刊名EUROPEAN JOURNAL OF NEUROSCIENCE
2007-06-01
DOI10.1111/j.1460-9568.2007.05598.x
25期:12页:3667-3677
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]TEMPORAL-LOBE EPILEPSY ; HIPPOCAMPAL SYNAPTIC PLASTICITY ; VISUAL-SPATIAL MEMORY ; FREELY-BEHAVING RATS ; PLACE CELLS ; STATUS EPILEPTICUS ; NEONATAL SEIZURES ; COGNITIVE IMPAIRMENT ; ATTENDED EXPERIENCE ; PYRAMIDAL CELLS
英文摘要

Patients with epilepsy are at substantial risk for memory impairment. Animal studies have paralleled these clinical observations, demonstrating impaired hippocampal function as measured by spatial memory in rodents subjected to seizures. However, the mechanism of seizure-induced hippocampal impairment is unclear. Here we investigated the effects of recurrent seizures on water-maze performance, a behavioural measure of learning and memory, long-term potentiation (LTP; considered a test of synaptic plasticity and memory) and place-cell firing patterns, a single-cell indicator of spatial memory. LTP and CA1 place-cell activity were examined in separate groups of freely moving rats, before and after 10 flurothyl-induced seizures. Water maze performance was examined in a third group of rats, five with previously induced seizures and five controls. Recurrent flurothyl seizures were associated with marked impairment in LTP and a reduction in the frequency of the peak theta power. Compared to baseline recordings, place-cell firing patterns following recurrent seizures were significantly less precise, had lower firing rates and were less stable. Impaired place-cell firing was seen as early as after two seizures and persisted at least 72 h after the last seizure. Water-maze performance was also significantly impaired in animals that underwent recurrent seizures. No cell loss or synaptic reorganization was observed in the hippocampus or in several other cortical areas that are vulnerable to seizures. These results demonstrate that relatively brief excitatory events, not producing visible cell damage, can nevertheless cause long-lasting changes in hippocampal physiology, observable as impairments in place-cell function, LTP and spatial memory.

语种英语
WOS记录号WOS:000247662100018
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被引频次:42[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54145
专题北京大学第二临床医学院_神经内科
作者单位1.Dartmouth Hitchcock Med Ctr, Neurosci Ctr Dartmouth, Lebanon, NH 03756 USA
2.Peking Univ, Hlth Sci Ctr, Peoples Hosp, Dept Neurol, Beijing, Peoples R China
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GB/T 7714
Zhou, Jun-Li,Shatskikh, Tatiana N.,Liu, Xianzeng,et al. Impaired single cell firing and long-term potentiation parallels memory impairment following recurrent seizures[J]. EUROPEAN JOURNAL OF NEUROSCIENCE,2007,25(12):3667-3677.
APA Zhou, Jun-Li,Shatskikh, Tatiana N.,Liu, Xianzeng,&Holmes, Gregory L..(2007).Impaired single cell firing and long-term potentiation parallels memory impairment following recurrent seizures.EUROPEAN JOURNAL OF NEUROSCIENCE,25(12),3667-3677.
MLA Zhou, Jun-Li,et al."Impaired single cell firing and long-term potentiation parallels memory impairment following recurrent seizures".EUROPEAN JOURNAL OF NEUROSCIENCE 25.12(2007):3667-3677.
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