北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第二临床医学院  > 神经内科  > 期刊论文
学科主题: 临床医学
题名:
Impaired single cell firing and long-term potentiation parallels memory impairment following recurrent seizures
作者: Zhou, Jun-Li; Shatskikh, Tatiana N.; Liu, Xianzeng; Holmes, Gregory L.
关键词: EEG ; epilepsy ; interneurons ; place cells ; seizures
刊名: EUROPEAN JOURNAL OF NEUROSCIENCE
发表日期: 2007-06-01
DOI: 10.1111/j.1460-9568.2007.05598.x
卷: 25, 期:12, 页:3667-3677
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: TEMPORAL-LOBE EPILEPSY ; HIPPOCAMPAL SYNAPTIC PLASTICITY ; VISUAL-SPATIAL MEMORY ; FREELY-BEHAVING RATS ; PLACE CELLS ; STATUS EPILEPTICUS ; NEONATAL SEIZURES ; COGNITIVE IMPAIRMENT ; ATTENDED EXPERIENCE ; PYRAMIDAL CELLS
英文摘要:

Patients with epilepsy are at substantial risk for memory impairment. Animal studies have paralleled these clinical observations, demonstrating impaired hippocampal function as measured by spatial memory in rodents subjected to seizures. However, the mechanism of seizure-induced hippocampal impairment is unclear. Here we investigated the effects of recurrent seizures on water-maze performance, a behavioural measure of learning and memory, long-term potentiation (LTP; considered a test of synaptic plasticity and memory) and place-cell firing patterns, a single-cell indicator of spatial memory. LTP and CA1 place-cell activity were examined in separate groups of freely moving rats, before and after 10 flurothyl-induced seizures. Water maze performance was examined in a third group of rats, five with previously induced seizures and five controls. Recurrent flurothyl seizures were associated with marked impairment in LTP and a reduction in the frequency of the peak theta power. Compared to baseline recordings, place-cell firing patterns following recurrent seizures were significantly less precise, had lower firing rates and were less stable. Impaired place-cell firing was seen as early as after two seizures and persisted at least 72 h after the last seizure. Water-maze performance was also significantly impaired in animals that underwent recurrent seizures. No cell loss or synaptic reorganization was observed in the hippocampus or in several other cortical areas that are vulnerable to seizures. These results demonstrate that relatively brief excitatory events, not producing visible cell damage, can nevertheless cause long-lasting changes in hippocampal physiology, observable as impairments in place-cell function, LTP and spatial memory.

语种: 英语
WOS记录号: WOS:000247662100018
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54145
Appears in Collections:北京大学第二临床医学院_神经内科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Dartmouth Hitchcock Med Ctr, Neurosci Ctr Dartmouth, Lebanon, NH 03756 USA
2.Peking Univ, Hlth Sci Ctr, Peoples Hosp, Dept Neurol, Beijing, Peoples R China

Recommended Citation:
Zhou, Jun-Li,Shatskikh, Tatiana N.,Liu, Xianzeng,et al. Impaired single cell firing and long-term potentiation parallels memory impairment following recurrent seizures[J]. EUROPEAN JOURNAL OF NEUROSCIENCE,2007,25(12):3667-3677.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Zhou, Jun-Li]'s Articles
[Shatskikh, Tatiana N.]'s Articles
[Liu, Xianzeng]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Zhou, Jun-Li]‘s Articles
[Shatskikh, Tatiana N.]‘s Articles
[Liu, Xianzeng]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace