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The role of MAPK in the biphasic dose-response phenomenon induced by cadmium and mercury in HEK293 cells
Hao, Changfu; Hao, Weidong; Wei, Xuetao; Xing, Lina; Jiang, Jianjun; Shang, Lanqin
关键词Biphasic Dose-response Cadmium Mercury Mitogen-activated Protein Kinase Proliferation Apoptosis
刊名TOXICOLOGY IN VITRO
2009-06-01
DOI10.1016/j.tiv.2009.03.005
23期:4页:660-666
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Toxicology
研究领域[WOS]Toxicology
关键词[WOS]GROWTH-INHIBITION ; STRESS-RESPONSE ; KINASE CASCADE ; HORMESIS ; APOPTOSIS ; METALS ; PATHWAY ; ACTIVATION ; TOLERANCE ; EXPOSURE
英文摘要

Some studies show that Cd(2+) and Hg(2+) may induce cell proliferation and apoptosis via biphasic dose-response relationship in human cells. However, mechanisms underlying this phenomenon are still in puzzle. In this study, we aim at detecting the biphasic effects of Cd(2+) and Hg(2+) on proliferation and apoptosis of human embryonic kidney 293 (HEK293) cells, analyzing the change of the mitogen-activated protein kinase (MAPK) pathways, and discussing the relationship between them. The results demonstrate that Cd(2+) and Hg(2+) can stimulate cell proliferation at lower concentrations (0.05 and 0.5 mu M) but inhibit it at higher concentrations (50 and 500 mu M). Apoptosis increases at higher concentrations (50 and 500 mu M) of Cd(2+) and Hg(2+). While 0.5 mu M Cd(2+) and Hg(2+) decrease the JNK phosphorylation, 50 mu M Cd(2+) and Hg(2+) increase the JNK and P38 phosphorylation. When HEK293 cells are treated with 20 mu M JNK inhibitor or 100 mu M ERK1/2 inhibitor, the cell proliferation do not increase significantly at low concentrations (0.05 and 0.5 mu M), but still decrease at high concentrations (50 and 500 mu M). When HEK293 cells are treated with 20 mu M P38 inhibitor, the tendency of cell proliferation is not affected. Data in our study suggests that activation of MAPK pathway may be involved in the biphasic effect induced by Cd(2+) and Hg(2+). (C) 2009 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000267011400017
项目编号5062025
资助机构Natural Science Foundation of Beijing city
引用统计
被引频次:23[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54151
专题北京大学公共卫生学院_公共卫生学院
北京大学公共卫生学院_毒理学系
作者单位Peking Univ, Sch Publ Hlth, Dept Toxicol, Beijing 100083, Peoples R China
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GB/T 7714
Hao, Changfu,Hao, Weidong,Wei, Xuetao,et al. The role of MAPK in the biphasic dose-response phenomenon induced by cadmium and mercury in HEK293 cells[J]. TOXICOLOGY IN VITRO,2009,23(4):660-666.
APA Hao, Changfu,Hao, Weidong,Wei, Xuetao,Xing, Lina,Jiang, Jianjun,&Shang, Lanqin.(2009).The role of MAPK in the biphasic dose-response phenomenon induced by cadmium and mercury in HEK293 cells.TOXICOLOGY IN VITRO,23(4),660-666.
MLA Hao, Changfu,et al."The role of MAPK in the biphasic dose-response phenomenon induced by cadmium and mercury in HEK293 cells".TOXICOLOGY IN VITRO 23.4(2009):660-666.
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