IR@PKUHSC  > 北京大学药学院
学科主题药学
Simultaneous qualitative and quantitative analysis of phenolic acids and flavonoids for the quality control of Apocynum venetum L. leaves by HPLC-DAD-ESI-IT-TOF-MS and HPLC-DAD
An, Haijuan1; Wang, Hong1; Lan, Yuexiang1; Hashi, Yuki1,2; Chen, Shizhong1
关键词Apocynum Venetum L. L.aves Hplc-dad-esi-it-tof-ms Phenolic Acids Flavonoids Quantitative Determination Cluster Analysis
刊名JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
2013-11-01
DOI10.1016/j.jpba.2013.07.005
85页:295-304
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Analytical ; Pharmacology & Pharmacy
研究领域[WOS]Chemistry ; Pharmacology & Pharmacy
关键词[WOS]TRAP MASS-SPECTROMETRY ; OF-FLIGHT MASS ; ELECTROSPRAY-IONIZATION ; IDENTIFICATION ; CONSTITUENTS ; COMPONENTS ; LUOBUMA
英文摘要

A reliable method based on high performance liquid chromatography-diode array detector-electrospray ionization-ion trap-time of flight-mass spectrometry (HPLC-DAD-ESI-IT-TOF-MS) was developed for the identification of phenolic acids and flavonoids in Apocynum venetum L. leaves and its adulterant, Pocynum hendersonii (Hook. f.) Woodson leaves. A total of 21 compounds were identified or tentatively identified, including 4 phenolic acids and 17 flavonoids. 3-O-caffeoylquinic acid (3-CQA) and caffeic acid were detected for the first time in A. venetum leaves; 4-O-caffeoylquinic acid (4-CQA), 3-CQA, caffeic acid, quercetin-3-O-(6 ′′-O-malonyl)-galactoside, quercetin-3-O-(6 ′′-O-malonyl)-glucoside, kaempferol-3-O-(6 ′′-O-malonyl)-glucoside, kaempferol-3-O-(6 ′′-O-acetyl)-glucoside, and kaempferol-3-O-dihexoside were detected for the first time in P. hendersonii leaves. Cluster analysis was employed to analyze 24 batches of A. venetum leaves and 5 batches of P. hendersonii leaves collected from various regions in China. The analysis, which was based on the 21 compounds, indicated that profiles of these compounds were distinct between the two species, and among A. venetum leaf samples from different origins. 18 of these 21 compounds were selected as the markers and simultaneously analyzed by HPLC-DAD for the first time. The quantitative analytical method was validated and subsequently applied to the comprehensive quality evaluation of 24 batches of A. venetum leaves. (C) 2013 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000324351200039
项目编号2009ZX09301-010
资助机构Peking University Comprehensive Platform for Innovative Drug Research and Development ; Shimadzu (China) Company Limited
引用统计
被引频次:34[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54152
专题北京大学药学院
作者单位1.Peking Univ, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
2.Shimadzu China Co Ltd, Beijing 100020, Peoples R China
推荐引用方式
GB/T 7714
An, Haijuan,Wang, Hong,Lan, Yuexiang,et al. Simultaneous qualitative and quantitative analysis of phenolic acids and flavonoids for the quality control of Apocynum venetum L. leaves by HPLC-DAD-ESI-IT-TOF-MS and HPLC-DAD[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2013,85:295-304.
APA An, Haijuan,Wang, Hong,Lan, Yuexiang,Hashi, Yuki,&Chen, Shizhong.(2013).Simultaneous qualitative and quantitative analysis of phenolic acids and flavonoids for the quality control of Apocynum venetum L. leaves by HPLC-DAD-ESI-IT-TOF-MS and HPLC-DAD.JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,85,295-304.
MLA An, Haijuan,et al."Simultaneous qualitative and quantitative analysis of phenolic acids and flavonoids for the quality control of Apocynum venetum L. leaves by HPLC-DAD-ESI-IT-TOF-MS and HPLC-DAD".JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 85(2013):295-304.
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