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Isolation, structure determination and antibacterial activities of succinamide conjugate diacid from Acinetobacter sp. BJ-L
Wu, Dengfeng1; Chang, Haitao2; Wang, Yi3; Xin, Mingxiu1
关键词Antimicrobial Substance Cold-adapted Microorganisms Psychrotroph Succinamide Conjugate Diacid (Scd)
刊名MICROBIOLOGICAL RESEARCH
2011
DOI10.1016/j.micres.2010.04.003
166期:3页:155-160
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Microbiology
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
研究领域[WOS]Microbiology
关键词[WOS]ANTIBIOTIC-RESISTANCE ; PURIFICATION ; SEQUENCE ; PROTEIN ; ENZYME
英文摘要

Strain BJ-L was isolated from the a water sample taken from Xiao Yue River in Beijing and identified as Acinetobacter sp. BJ-L based on the study of its morphology, physiology, biochemistry and 16S rRNA gene sequence. A new antimicrobial substance was produced after the strain was incubated in potato extract medium at 15 degrees C for 72h. The antimicrobial substance was sequentially purified by reduced pressure condensation, EtOAc extract, and silica gel column chromatography. The structure of the antimicrobial substance was elucidated as succinamide conjugate diacid (SCD) by spectroscopic data interpretation. Structure analysis indicated that SCD is a novel compound and that it could inhibit the growth of some tested bacterial strains with the MIC of 2 mg/ml, such as Staphylococcus aureus, Bacillus subtilis, Enterobacter aerogenes and Escherichia coli. Moreover, no obvious toxicity has been found on cultured HUVEC cells with different concentrations of SCD at 5, 10, 15, and 20 mg/ml. Crown Copyright (C) 2010 Published by Elsevier GmbH. All rights reserved.

语种英语
所属项目编号30170001
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
WOS记录号WOS:000288769400003
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54154
Collection北京大学药学院
作者单位1.Beijing Normal Univ, Coll Life Sci, Beijing 100875, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Morden Res Ctr Tradit Chinese Med, Beijing, Peoples R China
3.Chinese Acad Chinese Med Sci, Expt Res Ctr, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Wu, Dengfeng,Chang, Haitao,Wang, Yi,et al. Isolation, structure determination and antibacterial activities of succinamide conjugate diacid from Acinetobacter sp. BJ-L[J]. MICROBIOLOGICAL RESEARCH,2011,166(3):155-160.
APA Wu, Dengfeng,Chang, Haitao,Wang, Yi,&Xin, Mingxiu.(2011).Isolation, structure determination and antibacterial activities of succinamide conjugate diacid from Acinetobacter sp. BJ-L.MICROBIOLOGICAL RESEARCH,166(3),155-160.
MLA Wu, Dengfeng,et al."Isolation, structure determination and antibacterial activities of succinamide conjugate diacid from Acinetobacter sp. BJ-L".MICROBIOLOGICAL RESEARCH 166.3(2011):155-160.
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