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学科主题: 药学
题名:
Isolation, structure determination and antibacterial activities of succinamide conjugate diacid from Acinetobacter sp. BJ-L
作者: Wu, Dengfeng1; Chang, Haitao2; Wang, Yi3; Xin, Mingxiu1
关键词: Antimicrobial substance ; Cold-adapted microorganisms ; Psychrotroph ; Succinamide conjugate diacid (SCD)
刊名: MICROBIOLOGICAL RESEARCH
发表日期: 2011
DOI: 10.1016/j.micres.2010.04.003
卷: 166, 期:3, 页:155-160
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Microbiology
研究领域[WOS]: Microbiology
关键词[WOS]: ANTIBIOTIC-RESISTANCE ; PURIFICATION ; SEQUENCE ; PROTEIN ; ENZYME
英文摘要:

Strain BJ-L was isolated from the a water sample taken from Xiao Yue River in Beijing and identified as Acinetobacter sp. BJ-L based on the study of its morphology, physiology, biochemistry and 16S rRNA gene sequence. A new antimicrobial substance was produced after the strain was incubated in potato extract medium at 15 degrees C for 72h. The antimicrobial substance was sequentially purified by reduced pressure condensation, EtOAc extract, and silica gel column chromatography. The structure of the antimicrobial substance was elucidated as succinamide conjugate diacid (SCD) by spectroscopic data interpretation. Structure analysis indicated that SCD is a novel compound and that it could inhibit the growth of some tested bacterial strains with the MIC of 2 mg/ml, such as Staphylococcus aureus, Bacillus subtilis, Enterobacter aerogenes and Escherichia coli. Moreover, no obvious toxicity has been found on cultured HUVEC cells with different concentrations of SCD at 5, 10, 15, and 20 mg/ml. Crown Copyright (C) 2010 Published by Elsevier GmbH. All rights reserved.

语种: 英语
所属项目编号: 30170001
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000288769400003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54154
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Beijing Normal Univ, Coll Life Sci, Beijing 100875, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Morden Res Ctr Tradit Chinese Med, Beijing, Peoples R China
3.Chinese Acad Chinese Med Sci, Expt Res Ctr, Beijing, Peoples R China

Recommended Citation:
Wu, Dengfeng,Chang, Haitao,Wang, Yi,et al. Isolation, structure determination and antibacterial activities of succinamide conjugate diacid from Acinetobacter sp. BJ-L[J]. MICROBIOLOGICAL RESEARCH,2011,166(3):155-160.
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