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学科主题: 药学
题名:
Saponins in the genus Panax L. (Araliaceae): A systematic review of their chemical diversity
作者: Yang, Wen-zhi1; Hu, Ying2; Wu, Wan-ying1; Ye, Min2; Guo, De-an1
关键词: Panax genus ; Panax ginseng ; Panax quinquefolius ; Panax notoginseng ; Araliaceae ; Saponins ; Chemical diversity ; Subtype classification
刊名: PHYTOCHEMISTRY
发表日期: 2014-10-01
DOI: 10.1016/j.phytochem.2014.07.012
卷: 106, 页:7-24
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Plant Sciences
研究领域[WOS]: Biochemistry & Molecular Biology ; Plant Sciences
关键词[WOS]: DAMMARANE-TYPE SAPONINS ; KOREAN RED GINSENG ; HEAT-PROCESSED GINSENG ; ORIENTAL PLANT DRUGS ; F H. CHEN ; FLOWER-BUDS ; TRITERPENE SAPONINS ; QUINQUEFOLIUM-L ; CA MEYER ; BIOACTIVE SAPONINS
英文摘要:

The Panax genus is a crucial source of natural medicines that has benefited human health for a long time. Three valuable medicinal herbs, namely Panax ginseng, Panax quinquefolius, and Panax notoginseng, have received considerable interest due to their extensive application in clinical therapy, healthcare products, and as foods and food additives world-wide. Panax species are known to contain abundant levels of saponins, also dubbed ginsenosides, which refer to a series of dammarane or oleanane type triterpenoid glycosides. These saponins exhibit modulatory effects to the central nervous system and beneficial effects to patients suffering from cardiovascular diseases, and also have anti-diabetic and anti-tumor properties. To the end of 2012, at least 289 saponins were reported from eleven different Panax species. This comprehensive review describes the advances in the phytochemistry of the genus Panax for the period 1963-2012, based on the 134 cited references. The reported saponins can be classified into protopanaxadiol, protopanaxatriol, octillol, oleanolic acid, C17 side-chain varied, and miscellaneous subtypes, according to structural differences in sapogenins. The investigational history of Panax is also reviewed, with special attention being paid to the structural features of the six different subtypes, together with their H-1 and C-13 NMR spectroscopic characteristics which are useful for determining their structures and absolute configuration. (C) 2014 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: BMU20110269
项目资助者: Program for New Century Excellent Talents in University from China Ministry of Education
WOS记录号: WOS:000342258600001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54160
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Chinese Acad Sci, Shanghai Res Ctr Modernizat Tradit Chinese Med, Natl Engn Lab TCM Standardizat Technol, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

Recommended Citation:
Yang, Wen-zhi,Hu, Ying,Wu, Wan-ying,et al. Saponins in the genus Panax L. (Araliaceae): A systematic review of their chemical diversity[J]. PHYTOCHEMISTRY,2014,106:7-24.
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