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Estrogenic activity of furanocoumarins isolated from Angelica dahurica
Piao, Xiang Lan; Yoo, Hye Hyun; Kim, Hyun Young; Kang, Tak Lim; Hwang, Gwi Seo; Park, Jeong Hill
关键词Angelica Dahurica Umbelliferae Furanocoumarin Estrogenic Activity
刊名ARCHIVES OF PHARMACAL RESEARCH
2006-09-01
29期:9页:741-745
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]BREAST-CANCER ; POSTMENOPAUSAL ; PHYTOESTROGENS ; COUMARINS ; WOMEN ; RISK
英文摘要

In our efforts to discover novel phytoestrogens to treat menopausal symptoms, eleven furanocoumarins were isolated from Angelica dahurica and tested for their estrogenic activity on the Ishikawa cell line. Among the compounds tested, 9-hydroxy-4-methoxypsoralen and alloisoimperatorin showed strong abilities to induce alkaline phosphatase (AP) with EC50 values of 1.1 and 0.8 mu g/mL, respectively, whereas the other nine furanocoumarins were weakly or only slightly active.

语种英语
WOS记录号WOS:000240882200004
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54161
专题北京大学药学院
作者单位1.Seoul Natl Univ, Coll Pharm, Res Inst Pharmaceut Sci, Seoul 151742, South Korea
2.Peking Univ, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
3.Korea Inst Sci & Technol, Bioanal & Biotransformat Res Ctr, Seoul 130650, South Korea
4.Taejon Univ, Coll Oriental Med, Taejon 300120, South Korea
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GB/T 7714
Piao, Xiang Lan,Yoo, Hye Hyun,Kim, Hyun Young,et al. Estrogenic activity of furanocoumarins isolated from Angelica dahurica[J]. ARCHIVES OF PHARMACAL RESEARCH,2006,29(9):741-745.
APA Piao, Xiang Lan,Yoo, Hye Hyun,Kim, Hyun Young,Kang, Tak Lim,Hwang, Gwi Seo,&Park, Jeong Hill.(2006).Estrogenic activity of furanocoumarins isolated from Angelica dahurica.ARCHIVES OF PHARMACAL RESEARCH,29(9),741-745.
MLA Piao, Xiang Lan,et al."Estrogenic activity of furanocoumarins isolated from Angelica dahurica".ARCHIVES OF PHARMACAL RESEARCH 29.9(2006):741-745.
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