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学科主题: 药学
题名:
Estrogenic activity of furanocoumarins isolated from Angelica dahurica
作者: Piao, Xiang Lan; Yoo, Hye Hyun; Kim, Hyun Young; Kang, Tak Lim; Hwang, Gwi Seo; Park, Jeong Hill
关键词: Angelica dahurica ; Umbelliferae ; furanocoumarin ; estrogenic activity
刊名: ARCHIVES OF PHARMACAL RESEARCH
发表日期: 2006-09-01
卷: 29, 期:9, 页:741-745
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: BREAST-CANCER ; POSTMENOPAUSAL ; PHYTOESTROGENS ; COUMARINS ; WOMEN ; RISK
英文摘要:

In our efforts to discover novel phytoestrogens to treat menopausal symptoms, eleven furanocoumarins were isolated from Angelica dahurica and tested for their estrogenic activity on the Ishikawa cell line. Among the compounds tested, 9-hydroxy-4-methoxypsoralen and alloisoimperatorin showed strong abilities to induce alkaline phosphatase (AP) with EC50 values of 1.1 and 0.8 mu g/mL, respectively, whereas the other nine furanocoumarins were weakly or only slightly active.

语种: 英语
WOS记录号: WOS:000240882200004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54161
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Seoul Natl Univ, Coll Pharm, Res Inst Pharmaceut Sci, Seoul 151742, South Korea
2.Peking Univ, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
3.Korea Inst Sci & Technol, Bioanal & Biotransformat Res Ctr, Seoul 130650, South Korea
4.Taejon Univ, Coll Oriental Med, Taejon 300120, South Korea

Recommended Citation:
Piao, Xiang Lan,Yoo, Hye Hyun,Kim, Hyun Young,et al. Estrogenic activity of furanocoumarins isolated from Angelica dahurica[J]. ARCHIVES OF PHARMACAL RESEARCH,2006,29(9):741-745.
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