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学科主题药学
Artanomadimers A-F: six new dimeric guaianolides from Artemisia anomala
Zan, Ke1; Chai, Xing-Yun2; Chen, Xiao-Qing3; Wu, Qing4; Fu, Qiang1; Zhou, Si-Xiang1; Tu, Peng-Fei1
关键词Artemisia Anomala Dimeric Guaianolides Artanoimadimers A-f Cytotoxic Activities
刊名TETRAHEDRON
2012-06-24
DOI10.1016/j.tet.2012.04.046
68期:25页:5060-5065
收录类别SCI ; IC
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Organic
资助者National Natural Science Foundation of China ; China Postdoctoral Science Foundation ; National Natural Science Foundation of China ; China Postdoctoral Science Foundation
研究领域[WOS]Chemistry
关键词[WOS]FARNESYL-PROTEIN TRANSFERASE ; SESQUITERPENE LACTONES ; CIRCULAR-DICHROISM ; DERIVATIVES ; INHIBITORS
英文摘要

A novel dimeric guaianolide with an unprecedented skeleton, named artanomadimer A (1), and five new analogues, artanomadimers B-F (2-6), were isolated from the aerial parts of Artemisia anomala. Their structures and stereochemistry were elucidated by extensive spectroscopic methods, and the absolute stereochemistry of compound 4 was confirmed by X-ray crystallographic analysis. Artanomadimer A (1) is probably formed through a Diels-Alder reaction with the new carbon carbon bond formation of C-11/C-2′ and C-13/C-5′ based on its structure. A cytotoxic evaluation showed that compounds 1 and 6 exhibited significant inhibitory effects against the cell growth of BGC-823 tumor cell lines with IC50 values of 2.71 and 6.25 mu M, respectively. (C) 2012 Elsevier Ltd. All rights reserved.

语种英语
所属项目编号30973629 ; 20110490251
资助者National Natural Science Foundation of China ; China Postdoctoral Science Foundation ; National Natural Science Foundation of China ; China Postdoctoral Science Foundation
WOS记录号WOS:000304892800017
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54170
专题北京大学药学院
作者单位1.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Beijing Univ Chinese Med, Modern Res Ctr Tradit Chinese Med, Beijing 100029, Peoples R China
3.Capital Med Univ, Sch Tradit Chinese Med, Beijing 100069, Peoples R China
4.Guizhou Normal Univ, Key Lab Informat Syst Mountainous Area & Protect, Guiyang 550001, Peoples R China
推荐引用方式
GB/T 7714
Zan, Ke,Chai, Xing-Yun,Chen, Xiao-Qing,et al. Artanomadimers A-F: six new dimeric guaianolides from Artemisia anomala[J]. TETRAHEDRON,2012,68(25):5060-5065.
APA Zan, Ke.,Chai, Xing-Yun.,Chen, Xiao-Qing.,Wu, Qing.,Fu, Qiang.,...&Tu, Peng-Fei.(2012).Artanomadimers A-F: six new dimeric guaianolides from Artemisia anomala.TETRAHEDRON,68(25),5060-5065.
MLA Zan, Ke,et al."Artanomadimers A-F: six new dimeric guaianolides from Artemisia anomala".TETRAHEDRON 68.25(2012):5060-5065.
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