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学科主题: 精神卫生
题名:
Olanzapine versus lithium in the acute treatment of bipolar mania: A double-blind, randomized, controlled trial
作者: Niufan, Gu2; Tohen, Maunicio1,3; Qiuqing, Ang4; Fude, Yang5; Pope, Elizabeth; McElroy, Heather6; Ming, Li7; Gaohua, Wang8; Xinbao, Zhang9; Huichun, Li10; Liang, Shu11
关键词: olanzapine ; lithium carbonate ; bipolar disorder ; mania
刊名: JOURNAL OF AFFECTIVE DISORDERS
发表日期: 2008
DOI: 10.1106/j.jad.2007.04.020
卷: 105, 期:1-3, 页:101-108
收录类别: ISSHP ; SCI ; SSCI
文章类型: Proceedings Paper
WOS标题词: Science & Technology
类目[WOS]: Clinical Neurology ; Psychiatry
研究领域[WOS]: Neurosciences & Neurology ; Psychiatry
关键词[WOS]: RATING-SCALE ; DISORDER ; PLACEBO
英文摘要:

Background: This multicenter, double-blind, randomized, controlled study conducted in China examined the efficacy and safety of olanzapine versus lithium in the treatment of patients with bipolar manic/mixed episodes.

Methods: Patients with bipolar manic or mixed episode (DSM-IV criteria) and Young Mania Rating Scale (YMRS) score >= 20 at screening received olanzapine (5-20 mg/day, n = 69) or lithium carbonate (600-1800 mg/day, n = 7 1) for 4 weeks. The primary outcome was mean change from baseline in Clinical Global Impressions-Bipolar Version Overall Severity of Illness (CGI-BP) score. Secondary efficacy measures included YMRS, Brief Psychiatric Rating Scale (BPRS), and Montgomery-Asberg Depression Rating Scale (MADRS) scores. Safety was also assessed.

Results: A significantly greater mean change was observed in olanzapine versus lithium patients in CGI-BP (Overall Severity) (P=0.009), YMRS (P=0.013), BPRS (P=0.032), and CGI-BP (Severity of Mania) (P=0.012) scores. More olanzapine than lithium patients experienced at least one adverse event possibly related to study drug (P=0.038). More olanzapine patients had a clinically significant weight increase (>= 7% of baseline weight) compared to lithium patients (P=0.009). More olanzapine patients completed the study than lithium patients, although this difference was not statistically significant (olz, 91.3%; lith, 78.9%; P=0.057).

Limitations: No placebo arm was included; however both treatments have previously been reported to be more effective than placebo.

Conclusions: These results suggest that olanzapine has superior efficacy to lithium in the acute treatment of patients with bipolar mania over a 4-week period. However, adverse events were experienced by a greater number of olanzapine patients than lithium patients. (C) 2007 Elsevier B.V. All fights reserved.

语种: 英语
WOS记录号: WOS:000252905200011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54172
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Eli Lilly Australia, Macquarie Pk, NSW, Australia
2.Suzhow Psychiat Hosp, Suzhou, Peoples R China
3.Wuhan Univ, Renmin Hosp, Wuhan 430072, Peoples R China
4.Nanjing Brain Hosp, Nanjing, Peoples R China
5.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China
6.Beijing Hui Long Guan Hosp, Beijing, Peoples R China
7.Shanghai Mental Hlth Ctr, Shanghai, Peoples R China
8.Harvard Univ, Sch Med, McLean Hosp, Belmont, MA 02178 USA
9.Eli Lilly Asia, Shanghai, Peoples R China
10.Eli Lilly & Co, Lilly Res Labs, Indianapolis, IN 46285 USA
11.Zhejiang Univ, Coll Med, Affiliated Hosp 2, Hangzhou 310027, Peoples R China

Recommended Citation:
Niufan, Gu,Tohen, Maunicio,Qiuqing, Ang,et al. Olanzapine versus lithium in the acute treatment of bipolar mania: A double-blind, randomized, controlled trial[J]. JOURNAL OF AFFECTIVE DISORDERS,2008,105(1-3):101-108.
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