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学科主题: 临床医学
题名:
Aberrant methylation and loss of CADM2 tumor suppressor expression is associated with human renal cell carcinoma tumor progression
作者: He, Wei1,2,3; Li, Xuesong1,2,3; Xu, Shuping4; Ai, Junkui5; Gong, Yanqing1,2,3; Gregg, Jennifer L.5; Guan, Ruili1,2,3; Qiu, Wei1,2,3; Xin, Dianqi1,2,3; Gingrich, Jeffrey R.5; Guo, Yinglu1,2,3; Chang, Guimin5
关键词: CADM2 ; Renal cell carcinoma ; Methylation ; Tumor suppressor
刊名: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
发表日期: 2013-06-14
DOI: 10.1016/j.bbrc.2013.04.074
卷: 435, 期:4, 页:526-532
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]: SUPPRESSOR GENE ; LUNG-CANCER ; HETEROZYGOSITY ; ADHESION
英文摘要:

Cell adhesion molecules (CADMs) comprise a protein family whose functions include maintenance of cell polarity and tumor suppression. In this report, we show that the CADM2 gene is repressed in human clear renal cell carcinoma by DNA promoter hypermethylation and/or loss of heterozygosity. Moreover, the loss of CADM2 expression is associated with a higher tumor pathology stage (p < 0.05). The re-expression of CADM2 in the renal cancer cell line 786-O significantly suppressed tumor cell growth in vitro and in mouse xenografts by a G1 phase cell cycle arrest and the induction of apoptosis. Lentivirus-mediated CADM2 expression also significantly suppressed cancer cell anchorage-independent growth and invasion. Furthermore, the inhibition of endogenous CADM2 expression using siRNAs induced a tumorigenic phenotype in polarized non-tumorigenic MDCK cells. Thus, we conclude that CADM2 functions as a novel tumor suppressor and may serve as a potential therapeutic target for human renal cell carcinoma. (c) 2013 Elsevier Inc. All rights reserved.

语种: 英语
项目资助者: China Health &amp ; Medical Development Foundation
WOS记录号: WOS:000321025800004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54175
Appears in Collections:北京大学第一临床医学院_泌尿外科_期刊论文

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作者单位: 1.Natl Urol Canc Ctr, Beijing 100034, Peoples R China
2.Peking Univ, Inst Urol, Beijing 100034, Peoples R China
3.Peking Univ, Hosp 1, Dept Urol, Beijing 100034, Peoples R China
4.Univ Pittsburgh, Sch Med, Dept Pharmacol & Chem Biol, Pittsburgh, PA 15261 USA
5.Univ Pittsburgh, Dept Urol, Pittsburgh, PA 15232 USA

Recommended Citation:
He, Wei,Li, Xuesong,Xu, Shuping,et al. Aberrant methylation and loss of CADM2 tumor suppressor expression is associated with human renal cell carcinoma tumor progression[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2013,435(4):526-532.
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