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A Meta-Analysis of Chinese Herbal Medicine in Treatment of Managed Withdrawal from Heroin
Liu, Ting-Ting1; Shi, Jie1; Epstein, David H.2; Bao, Yan-Ping1; Lu, Lin1
关键词Chinese Herbal Medicine Heroin Detoxification Meta-analysis
刊名CELLULAR AND MOLECULAR NEUROBIOLOGY
2009-02-01
DOI10.1007/s10571-008-9290-1
29期:1页:17-25
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology ; Neurosciences
研究领域[WOS]Cell Biology ; Neurosciences & Neurology
关键词[WOS]RANDOMIZED CONTROLLED-TRIAL ; ACUTE OPIOID WITHDRAWAL ; DETOXIFICATION ; ADDICTION ; IBOGAINE
英文摘要

Chinese herbal medicine has shown promise for heroin detoxification. This review extends a prior meta-analysis of Chinese herbal medicine for heroin detoxification, with particular attention to the time course of symptoms. Both English and Chinese databases were searched for randomized trials comparing Chinese herbal medicine to either alpha 2-adrenergic agonists or opioid agonists for heroin detoxification. The methodological quality of each study was assessed with Jadad′s scale (1-2 = low; 3-5 = high). Meta-analysis was performed with fixed- or random-effect models in RevMan software; outcome measures assessed were withdrawal-symptoms score, anxiety, and adverse effects of treatment. Twenty-one studies (2,949 participants) were included. For withdrawal-symptoms score relieving during the 10-day observation, Chinese herbal medicine was superior to alpha 2-adrenergic agonists in relieving opioid-withdrawal symptoms during 4-10 days (except D8) and no difference was found within the first 3 days. Compared with opioid agonists, Chinese herbal medicine was inferior during the first 3 days, but the difference became non-significant during days 4-9. Chinese herbal medicine has better effect on anxiety relieving at late stage of intervention than alpha 2-adrenergic agonists, and no difference with opioid agonists. The incidence of some adverse effects (fatigue, dizziness) was significantly lower for Chinese herbal medicine than for alpha 2-adrenergic agonists (sufficient data for comparison with opioid agonists were not available). Findings were robust to file-drawer effects. Our meta-analysis suggests that Chinese herbal medicine is an effective and safety treatment for heroin detoxification. And more work is needed to determine the specific effects of specific forms of Chinese herbal medicine.

语种英语
WOS记录号WOS:000263114100003
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54179
专题北京大学第三临床医学院_总务处
中国药物依赖性研究所
作者单位1.Peking Univ, Natl Inst Drug Dependence, Beijing 100083, Peoples R China
2.NIDA, Intramural Res Program, NIH, Baltimore, MD 21224 USA
推荐引用方式
GB/T 7714
Liu, Ting-Ting,Shi, Jie,Epstein, David H.,et al. A Meta-Analysis of Chinese Herbal Medicine in Treatment of Managed Withdrawal from Heroin[J]. CELLULAR AND MOLECULAR NEUROBIOLOGY,2009,29(1):17-25.
APA Liu, Ting-Ting,Shi, Jie,Epstein, David H.,Bao, Yan-Ping,&Lu, Lin.(2009).A Meta-Analysis of Chinese Herbal Medicine in Treatment of Managed Withdrawal from Heroin.CELLULAR AND MOLECULAR NEUROBIOLOGY,29(1),17-25.
MLA Liu, Ting-Ting,et al."A Meta-Analysis of Chinese Herbal Medicine in Treatment of Managed Withdrawal from Heroin".CELLULAR AND MOLECULAR NEUROBIOLOGY 29.1(2009):17-25.
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