北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 中国药物依赖性研究所  > 期刊论文
学科主题: 药物依赖
题名:
A Meta-Analysis of Chinese Herbal Medicine in Treatment of Managed Withdrawal from Heroin
作者: Liu, Ting-Ting1; Shi, Jie1; Epstein, David H.2; Bao, Yan-Ping1; Lu, Lin1
关键词: Chinese herbal medicine ; Heroin ; Detoxification ; Meta-analysis
刊名: CELLULAR AND MOLECULAR NEUROBIOLOGY
发表日期: 2009-02-01
DOI: 10.1007/s10571-008-9290-1
卷: 29, 期:1, 页:17-25
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology ; Neurosciences
研究领域[WOS]: Cell Biology ; Neurosciences & Neurology
关键词[WOS]: RANDOMIZED CONTROLLED-TRIAL ; ACUTE OPIOID WITHDRAWAL ; DETOXIFICATION ; ADDICTION ; IBOGAINE
英文摘要:

Chinese herbal medicine has shown promise for heroin detoxification. This review extends a prior meta-analysis of Chinese herbal medicine for heroin detoxification, with particular attention to the time course of symptoms. Both English and Chinese databases were searched for randomized trials comparing Chinese herbal medicine to either alpha 2-adrenergic agonists or opioid agonists for heroin detoxification. The methodological quality of each study was assessed with Jadad′s scale (1-2 = low; 3-5 = high). Meta-analysis was performed with fixed- or random-effect models in RevMan software; outcome measures assessed were withdrawal-symptoms score, anxiety, and adverse effects of treatment. Twenty-one studies (2,949 participants) were included. For withdrawal-symptoms score relieving during the 10-day observation, Chinese herbal medicine was superior to alpha 2-adrenergic agonists in relieving opioid-withdrawal symptoms during 4-10 days (except D8) and no difference was found within the first 3 days. Compared with opioid agonists, Chinese herbal medicine was inferior during the first 3 days, but the difference became non-significant during days 4-9. Chinese herbal medicine has better effect on anxiety relieving at late stage of intervention than alpha 2-adrenergic agonists, and no difference with opioid agonists. The incidence of some adverse effects (fatigue, dizziness) was significantly lower for Chinese herbal medicine than for alpha 2-adrenergic agonists (sufficient data for comparison with opioid agonists were not available). Findings were robust to file-drawer effects. Our meta-analysis suggests that Chinese herbal medicine is an effective and safety treatment for heroin detoxification. And more work is needed to determine the specific effects of specific forms of Chinese herbal medicine.

语种: 英语
所属项目编号: 2003CB515400 ; 2006AA02Z4D1 ; 30611120528
项目资助者: National Basic Research Program of China ; National High Technology Research and Development Program of China ; China-Canada Joint Health Research Program
WOS记录号: WOS:000263114100003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54179
Appears in Collections:中国药物依赖性研究所_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Natl Inst Drug Dependence, Beijing 100083, Peoples R China
2.NIDA, Intramural Res Program, NIH, Baltimore, MD 21224 USA

Recommended Citation:
Liu, Ting-Ting,Shi, Jie,Epstein, David H.,et al. A Meta-Analysis of Chinese Herbal Medicine in Treatment of Managed Withdrawal from Heroin[J]. CELLULAR AND MOLECULAR NEUROBIOLOGY,2009,29(1):17-25.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Liu, Ting-Ting]'s Articles
[Shi, Jie]'s Articles
[Epstein, David H.]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Liu, Ting-Ting]‘s Articles
[Shi, Jie]‘s Articles
[Epstein, David H.]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace