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学科主题: 临床医学
题名:
A placebo-controlled trial of 10-day bismuth-based quadruple therapy to eradicate Helicobacter pylori infection; a pilot study for the large Linqu County trial
作者: Ma, Junling1; Liu, Weidong2; Zhang, Lian1; Pan, Kaifeng1; Zhao, Hongjun2; Zhou, Tong1; Winawer, Sidney3; Zauber, Ann3; Classen, Meinhard4; You, Weicheng1
关键词: 10-day quadruple therapy ; H. pylori infection ; population-based study
刊名: EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
发表日期: 2010-05-01
DOI: 10.1097/MEG.0b013e3283337146
卷: 22, 期:5, 页:597-601
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
关键词[WOS]: PRECANCEROUS GASTRIC-LESIONS ; CHINESE POPULATION ; TRIPLE THERAPY ; ULCER PATIENTS ; CANCER ; RISK ; METRONIDAZOLE ; BISKALCITRATE ; TETRACYCLINE ; MULTICENTER
英文摘要:

Aim To explore a low-cost and highly-effective therapy for eradication of Helicobacter pylori (H. pylori), a placebo-controlled trial of quadruple therapy was conducted in a population at high risk of gastric cancer in Linqu County of Shandong Province, China.

Methods Two hundred and seventy-seven adults aged 35-54 years with H. pylori infection in three villages were assigned to two groups: treatment (n=189 in two villages) and placebo (n=88 in one village). Participants received either a 10-day oral quadruple therapy regimen with omeprazole (20 mg, twice daily); tetracycline (750 mg, three times daily); metronidazole (500 mg, three times daily) and bismuth potassium citrate (300 mg, twice daily), or a similar lookalike placebo regimen. The status of H. pylori infection in each trial participant before and after six weeks of treatment was determined by a 13 C-urea breath test.

Results One hundred and seventy-four of 189 participants completed the quadruple therapy (92.1%) and 84 participants completed the placebo therapy (95.5%). The H. pylori eradication rate by intention-to-treat analysis was 76.7% (145 of 189) in the treatment group and 1.1% (1 of 88) in the placebo group, respectively; by per-protocol analysis it was 83.3% (145 of 174) in the treatment group and 1.2% (1 of 84) in the placebo group, respectively.

Conclusion In a high-risk area of gastric cancer, we conducted a high compliance, tolerable, low side-effect and lowcost therapy of anti-H. pylori. The eradication rate of the 10-day quadruple treatment was more than 80% and significantly higher than the triple therapy regimen used in this population in an earlier trial. Eur J Gastroenterol Hepatol 22:597-601 (C) 2010 Wolters Kluwer Health | Lippincott Williams & Wilkins.

语种: 英语
所属项目编号: 2006BA102A05
项目资助者: Peking University School of Oncology, China ; Gastroenterology Foundation Munich, German ; International Digestive Cancer Alliance
WOS记录号: WOS:000277308600015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54181
Appears in Collections:北京大学临床肿瘤学院_期刊论文

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作者单位: 1.Linqu Publ Hlth Bur, Linqu, Shandong, Peoples R China
2.Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA
3.Tech Univ, Munich, Germany
4.Peking Univ, Sch Oncol, Key Lab Carcinogenesis & Translat Res,Minist Educ, Dept Epidemiol,Beijing Canc Hosp & Inst, Beijing 100142, Peoples R China

Recommended Citation:
Ma, Junling,Liu, Weidong,Zhang, Lian,et al. A placebo-controlled trial of 10-day bismuth-based quadruple therapy to eradicate Helicobacter pylori infection; a pilot study for the large Linqu County trial[J]. EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY,2010,22(5):597-601.
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