|Vitamin D Status Is an Independent Risk Factor for Global Cognitive Impairment in Peritoneal Dialysis Patients|
|Liu, Gui-Ling1; Pi, Hai-Chen2; Hao, Li1; Li, Dan-Dan1; Wu, Yong-Gui1; Dong, Jie2|
|收录类别||SCI ; SSCI|
|WOS标题词||Science & Technology|
|研究领域[WOS]||Science & Technology - Other Topics|
|关键词[WOS]||CHRONIC KIDNEY-DISEASE ; HEMODIALYSIS-PATIENTS ; 25-HYDROXYVITAMIN D ; METABOLIC SYNDROME ; D INSUFFICIENCY ; CHOLECALCIFEROL ; ADULTS ; SUPPLEMENTATION ; ASSOCIATION ; PERFORMANCE|
Vitamin D (VD) deficiency is an independent risk factor for cognitive impairment (CI) in the general population, but VD status in peritoneal dialysis (PD) patients has not been investigated. In this study, we aimed to investigate the relationship between serum VD levels and global and specific cognitive functions in PD patients.
Design and Setting
Cross-sectional study, simultaneously conducted at two PD centers.
Clinically stable patients (n = 273) undergoing PD for at least 3 months were enrolled over a period of one year.
Main outcome Measures
Demographic and comorbidity data were recorded, and routine biochemical parameters and serum 25-hydroxyvitamin D (25(OH) D) levels of overnight fasted patients were determined. Global cognitive function was assessed by the Modified Mini-Mental State Examination (3MS) score; executive function, by the trail making tests (Trails A and B); and immediate memory, delayed memory, and language ability by the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) sub-tests.
In the univariate analysis, serum 25(OH) D levels significantly correlated with 3MS scores (r = -0.139; P = 0.02), and Trail A (r = -0.188; P = 0.002) and B (r = -0.154; P = 0.01) completion times. In the multivariate analysis, 25(OH) D was found to be independently associated with global CI, but not with executive dysfunction. Serum 25(OH) D could not predict scores of immediate/delayed memory and language ability.
VD deficiency is highly prevalent in PD patients and is an independent risk factor for global CI in this patient cohort.
|作者单位||1.Anhui Med Univ, Hosp 2, Div Renal, Hefei, Anhui, Peoples R China|
2.Peking Univ, Div Renal, Dept Med,Minist Educ, Hosp 1,Inst Nephrol,Key Lab Renal Dis,Minist Hlth, Beijing 100871, Peoples R China
|Liu, Gui-Ling,Pi, Hai-Chen,Hao, Li,et al. Vitamin D Status Is an Independent Risk Factor for Global Cognitive Impairment in Peritoneal Dialysis Patients[J]. PLOS ONE,2015,10(12).|
|APA||Liu, Gui-Ling,Pi, Hai-Chen,Hao, Li,Li, Dan-Dan,Wu, Yong-Gui,&Dong, Jie.(2015).Vitamin D Status Is an Independent Risk Factor for Global Cognitive Impairment in Peritoneal Dialysis Patients.PLOS ONE,10(12).|
|MLA||Liu, Gui-Ling,et al."Vitamin D Status Is an Independent Risk Factor for Global Cognitive Impairment in Peritoneal Dialysis Patients".PLOS ONE 10.12(2015).|