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学科主题临床医学
Vitamin D Status Is an Independent Risk Factor for Global Cognitive Impairment in Peritoneal Dialysis Patients
Liu, Gui-Ling1; Pi, Hai-Chen2; Hao, Li1; Li, Dan-Dan1; Wu, Yong-Gui1; Dong, Jie2
刊名PLOS ONE
2015-12-02
DOI10.1371/journal.pone.0143782
10期:12
收录类别SCI ; SSCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]CHRONIC KIDNEY-DISEASE ; HEMODIALYSIS-PATIENTS ; 25-HYDROXYVITAMIN D ; METABOLIC SYNDROME ; D INSUFFICIENCY ; CHOLECALCIFEROL ; ADULTS ; SUPPLEMENTATION ; ASSOCIATION ; PERFORMANCE
英文摘要

Objective

Vitamin D (VD) deficiency is an independent risk factor for cognitive impairment (CI) in the general population, but VD status in peritoneal dialysis (PD) patients has not been investigated. In this study, we aimed to investigate the relationship between serum VD levels and global and specific cognitive functions in PD patients.

Design and Setting

Cross-sectional study, simultaneously conducted at two PD centers.

Patients

Clinically stable patients (n = 273) undergoing PD for at least 3 months were enrolled over a period of one year.

Main outcome Measures

Demographic and comorbidity data were recorded, and routine biochemical parameters and serum 25-hydroxyvitamin D (25(OH) D) levels of overnight fasted patients were determined. Global cognitive function was assessed by the Modified Mini-Mental State Examination (3MS) score; executive function, by the trail making tests (Trails A and B); and immediate memory, delayed memory, and language ability by the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) sub-tests.

Results

In the univariate analysis, serum 25(OH) D levels significantly correlated with 3MS scores (r = -0.139; P = 0.02), and Trail A (r = -0.188; P = 0.002) and B (r = -0.154; P = 0.01) completion times. In the multivariate analysis, 25(OH) D was found to be independently associated with global CI, but not with executive dysfunction. Serum 25(OH) D could not predict scores of immediate/delayed memory and language ability.

Conclusions

VD deficiency is highly prevalent in PD patients and is an independent risk factor for global CI in this patient cohort.

语种英语
WOS记录号WOS:000365926300098
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54186
Collection北京大学第一临床医学院_肾脏内科
作者单位1.Anhui Med Univ, Hosp 2, Div Renal, Hefei, Anhui, Peoples R China
2.Peking Univ, Div Renal, Dept Med,Minist Educ, Hosp 1,Inst Nephrol,Key Lab Renal Dis,Minist Hlth, Beijing 100871, Peoples R China
Recommended Citation
GB/T 7714
Liu, Gui-Ling,Pi, Hai-Chen,Hao, Li,et al. Vitamin D Status Is an Independent Risk Factor for Global Cognitive Impairment in Peritoneal Dialysis Patients[J]. PLOS ONE,2015,10(12).
APA Liu, Gui-Ling,Pi, Hai-Chen,Hao, Li,Li, Dan-Dan,Wu, Yong-Gui,&Dong, Jie.(2015).Vitamin D Status Is an Independent Risk Factor for Global Cognitive Impairment in Peritoneal Dialysis Patients.PLOS ONE,10(12).
MLA Liu, Gui-Ling,et al."Vitamin D Status Is an Independent Risk Factor for Global Cognitive Impairment in Peritoneal Dialysis Patients".PLOS ONE 10.12(2015).
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