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学科主题: 口腔医学
题名:
M1-like Macrophage Polarization Promotes Orthodontic Tooth Movement
作者: He, D.1,2; Kou, X.1,2; Yang, R.1,2; Liu, D.1,2; Wang, X.1,2; Luo, Q.1,2; Song, Y.1,2; Liu, F.1,2; Yan, Y.1,2; Gan, Y.3; Zhou, Y.1,2
关键词: orthodontics ; biomechanical phenomena ; bone resorption ; inflammation ; macrophage activation ; osteoclasts
刊名: JOURNAL OF DENTAL RESEARCH
发表日期: 2015-09-01
DOI: 10.1177/0022034515589714
卷: 94, 期:9, 页:1286-1294
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Dentistry, Oral Surgery & Medicine
研究领域[WOS]: Dentistry, Oral Surgery & Medicine
关键词[WOS]: PERIODONTAL-LIGAMENT CELLS ; PULMONARY-HYPERTENSION ; BONE-RESORPTION ; INFLAMMATION ; FIBROBLASTS ; MONOCYTES ; OSTEOCLASTS ; ACTIVATION ; DIFFERENTIATION ; COMPRESSION
英文摘要:

Macrophages play a crucial role in inflammatory-mediated bone loss. Orthodontic tooth movement (OTM) is associated with inflammatory bone remodeling. However, whether and how macrophages contribute to mechanical force-induced OTM remains unknown. In this study, we hypothesized that polarization of M1-like macrophages may contribute to the OTM. Orthodontic nickel-titanium springs were applied to the upper first molars of rats or mice to induce OTM. The distance of OTM gradually increased after mechanical force was applied to the rats for 5 and 10 d. M1-like macrophage polarization and expression of M1 cytokine tumor necrosis factor (TNF)-alpha also increased after force application. More importantly, monocyte/macrophage depletion in mice by injection of clodronate liposomes decreased the distance of OTM and the number of tartrate-resistant acid phosphatase (TRAP)-positive osteoclasts and CD68(+) macrophages, accompanied by reduced expressions of M1 markers TNF-alpha and inducible nitric oxide synthase (iNOS), whereas systemic transfusion of M1 macrophages in mice increased them. Further experiments showed that injection of recombinant TNF-alpha increased the distance of OTM and the number of TRAP-positive osteoclasts and CD68(+) macrophages, as well as upregulated the expression of TNF-alpha and iNOS. Blockage of TNF-alpha by etanercept injection reduced the distance of OTM and the number of TRAP-positive osteoclasts and CD68(+) macrophages, as well as decreased the levels of TNF-alpha and iNOS. These data suggest that M1-like macrophage polarization promotes alveolar bone resorption and consequent OTM after mechanical force application.

语种: 英语
所属项目编号: 81300897 ; 81470717 ; 2013DFB 30360
项目资助者: National Natural Science Foundation of China ; International S&amp ; T Cooperation Program of China
WOS记录号: WOS:000360188900014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54200
Appears in Collections:北京大学口腔医学院_牙周科_期刊论文

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作者单位: 1.Peking Univ, Sch & Hosp Stomatol, Dept Orthodont, Beijing 100081, Peoples R China
2.Peking Univ, Ctr Craniofacial Stem Cell Res & Regenerat, Sch & Hosp Stomatol, Beijing 100081, Peoples R China
3.Peking Univ, Sch & Hosp Stomatol, Ctr Temporomandibular Disorders & Orofacial Pain, Beijing 100081, Peoples R China

Recommended Citation:
He, D.,Kou, X.,Yang, R.,et al. M1-like Macrophage Polarization Promotes Orthodontic Tooth Movement[J]. JOURNAL OF DENTAL RESEARCH,2015,94(9):1286-1294.
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