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学科主题口腔医学
M1-like Macrophage Polarization Promotes Orthodontic Tooth Movement
He, D.1,2; Kou, X.1,2; Yang, R.1,2; Liu, D.1,2; Wang, X.1,2; Luo, Q.1,2; Song, Y.1,2; Liu, F.1,2; Yan, Y.1,2; Gan, Y.3; Zhou, Y.1,2
关键词Orthodontics Biomechanical Phenomena Bone Resorption Inflammation Macrophage Activation Osteoclasts
刊名JOURNAL OF DENTAL RESEARCH
2015-09-01
DOI10.1177/0022034515589714
94期:9页:1286-1294
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Dentistry, Oral Surgery & Medicine
研究领域[WOS]Dentistry, Oral Surgery & Medicine
关键词[WOS]PERIODONTAL-LIGAMENT CELLS ; PULMONARY-HYPERTENSION ; BONE-RESORPTION ; INFLAMMATION ; FIBROBLASTS ; MONOCYTES ; OSTEOCLASTS ; ACTIVATION ; DIFFERENTIATION ; COMPRESSION
英文摘要

Macrophages play a crucial role in inflammatory-mediated bone loss. Orthodontic tooth movement (OTM) is associated with inflammatory bone remodeling. However, whether and how macrophages contribute to mechanical force-induced OTM remains unknown. In this study, we hypothesized that polarization of M1-like macrophages may contribute to the OTM. Orthodontic nickel-titanium springs were applied to the upper first molars of rats or mice to induce OTM. The distance of OTM gradually increased after mechanical force was applied to the rats for 5 and 10 d. M1-like macrophage polarization and expression of M1 cytokine tumor necrosis factor (TNF)-alpha also increased after force application. More importantly, monocyte/macrophage depletion in mice by injection of clodronate liposomes decreased the distance of OTM and the number of tartrate-resistant acid phosphatase (TRAP)-positive osteoclasts and CD68(+) macrophages, accompanied by reduced expressions of M1 markers TNF-alpha and inducible nitric oxide synthase (iNOS), whereas systemic transfusion of M1 macrophages in mice increased them. Further experiments showed that injection of recombinant TNF-alpha increased the distance of OTM and the number of TRAP-positive osteoclasts and CD68(+) macrophages, as well as upregulated the expression of TNF-alpha and iNOS. Blockage of TNF-alpha by etanercept injection reduced the distance of OTM and the number of TRAP-positive osteoclasts and CD68(+) macrophages, as well as decreased the levels of TNF-alpha and iNOS. These data suggest that M1-like macrophage polarization promotes alveolar bone resorption and consequent OTM after mechanical force application.

语种英语
WOS记录号WOS:000360188900014
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54200
专题北京大学口腔医学院_牙周科
北京大学基础医学院
北京大学口腔医学院_口腔正畸科
作者单位1.Peking Univ, Sch & Hosp Stomatol, Dept Orthodont, Beijing 100081, Peoples R China
2.Peking Univ, Ctr Craniofacial Stem Cell Res & Regenerat, Sch & Hosp Stomatol, Beijing 100081, Peoples R China
3.Peking Univ, Sch & Hosp Stomatol, Ctr Temporomandibular Disorders & Orofacial Pain, Beijing 100081, Peoples R China
推荐引用方式
GB/T 7714
He, D.,Kou, X.,Yang, R.,et al. M1-like Macrophage Polarization Promotes Orthodontic Tooth Movement[J]. JOURNAL OF DENTAL RESEARCH,2015,94(9):1286-1294.
APA He, D..,Kou, X..,Yang, R..,Liu, D..,Wang, X..,...&Zhou, Y..(2015).M1-like Macrophage Polarization Promotes Orthodontic Tooth Movement.JOURNAL OF DENTAL RESEARCH,94(9),1286-1294.
MLA He, D.,et al."M1-like Macrophage Polarization Promotes Orthodontic Tooth Movement".JOURNAL OF DENTAL RESEARCH 94.9(2015):1286-1294.
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