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Studies on the mechanism of testicular dysfunction in the early stage of a streptozotocin induced diabetic rat model
Xu, Yongde1,2,3; Lei, Hongen1,2,3; Guan, Ruili1,2,3; Gao, Zhezhu1; Li, Huixi1; Wang, Lin1; Song, Weidong1; Gao, Bing1; Xin, Zhongcheng1
关键词Streptozotocin Diabetes Mellitus Male Infertility Model
刊名BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
2014-07-18
DOI10.1016/j.bbrc.2014.05.067
450期:1页:87-92
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]GERM-CELL APOPTOSIS ; NF-KAPPA-B ; SERTOLI-CELL ; OXIDATIVE STRESS ; MICE ; VIMENTIN ; TESTIS ; ABNORMALITIES ; QUERCETIN ; SPERM
英文摘要

Streptozotocin (STZ) induced diabetic model has been widely used to study the effects of diabetes mellitus (DM) on male infertility, but it remains unclear whether the responses in this model are due to hyperglycemia or STZ per se. This study was designed to investigate the mechanism of STZ on testicular dysfunction. In the present study, sperm characteristics, serum testosterone, steroidogenic enzymes (StAR and 3 beta-HSD), and the vimentin apical extension of sertoli cells decreased significantly in the STZ group compared with those in the normal controls (p < 0.05), while Johnsen′s score, testicular lipid peroxidation, spermatogenic cell apoptosis, and the expressions of NF-kappa B and Wnt4 significantly increased (p < 0.05). Insulin replacement mainly restored the decreased serum testosterone and steroidogenic enzymes, but not other parameters. The results indicated that spermatogenic dysfunction in the early stage of STZ-induced diabetic rats was due to direct STZ cytotoxicity to sertoli cells, which could be regulated by Wnt4 and NF-kappa B, while steroidogenic dysfunction might be a direct or indirect consequence of insulin deficiency. The results suggested that STZ-induced diabetic model, at least in the early stage, is not suitable to study the diabetes-related spermatogenic dysfunction. (C) 2014 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000343641000015
项目编号81272531
资助机构National Nature Science Foundation of China
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54202
专题北京大学第一临床医学院_男科中心
北京大学第一临床医学院_泌尿外科
作者单位1.Peking Univ, Inst Urol, Beijing 100034, Peoples R China
2.Peking Univ, Hosp 1, Androl Ctr, Beijing 100034, Peoples R China
3.Peking Univ, Dept Urol, Hosp 1, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Xu, Yongde,Lei, Hongen,Guan, Ruili,et al. Studies on the mechanism of testicular dysfunction in the early stage of a streptozotocin induced diabetic rat model[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2014,450(1):87-92.
APA Xu, Yongde.,Lei, Hongen.,Guan, Ruili.,Gao, Zhezhu.,Li, Huixi.,...&Xin, Zhongcheng.(2014).Studies on the mechanism of testicular dysfunction in the early stage of a streptozotocin induced diabetic rat model.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,450(1),87-92.
MLA Xu, Yongde,et al."Studies on the mechanism of testicular dysfunction in the early stage of a streptozotocin induced diabetic rat model".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 450.1(2014):87-92.
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