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学科主题: 临床医学
题名:
Studies on the mechanism of testicular dysfunction in the early stage of a streptozotocin induced diabetic rat model
作者: Xu, Yongde1,2,3; Lei, Hongen1,2,3; Guan, Ruili1,2,3; Gao, Zhezhu1; Li, Huixi1; Wang, Lin1; Song, Weidong1; Gao, Bing1; Xin, Zhongcheng1
关键词: Streptozotocin ; Diabetes mellitus ; Male ; Infertility ; Model
刊名: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
发表日期: 2014-07-18
DOI: 10.1016/j.bbrc.2014.05.067
卷: 450, 期:1, 页:87-92
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]: GERM-CELL APOPTOSIS ; NF-KAPPA-B ; SERTOLI-CELL ; OXIDATIVE STRESS ; MICE ; VIMENTIN ; TESTIS ; ABNORMALITIES ; QUERCETIN ; SPERM
英文摘要:

Streptozotocin (STZ) induced diabetic model has been widely used to study the effects of diabetes mellitus (DM) on male infertility, but it remains unclear whether the responses in this model are due to hyperglycemia or STZ per se. This study was designed to investigate the mechanism of STZ on testicular dysfunction. In the present study, sperm characteristics, serum testosterone, steroidogenic enzymes (StAR and 3 beta-HSD), and the vimentin apical extension of sertoli cells decreased significantly in the STZ group compared with those in the normal controls (p < 0.05), while Johnsen′s score, testicular lipid peroxidation, spermatogenic cell apoptosis, and the expressions of NF-kappa B and Wnt4 significantly increased (p < 0.05). Insulin replacement mainly restored the decreased serum testosterone and steroidogenic enzymes, but not other parameters. The results indicated that spermatogenic dysfunction in the early stage of STZ-induced diabetic rats was due to direct STZ cytotoxicity to sertoli cells, which could be regulated by Wnt4 and NF-kappa B, while steroidogenic dysfunction might be a direct or indirect consequence of insulin deficiency. The results suggested that STZ-induced diabetic model, at least in the early stage, is not suitable to study the diabetes-related spermatogenic dysfunction. (C) 2014 Elsevier Inc. All rights reserved.

语种: 英语
所属项目编号: 81272531
项目资助者: National Nature Science Foundation of China
WOS记录号: WOS:000343641000015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54202
Appears in Collections:北京大学第一临床医学院_男科中心_期刊论文

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作者单位: 1.Peking Univ, Inst Urol, Beijing 100034, Peoples R China
2.Peking Univ, Hosp 1, Androl Ctr, Beijing 100034, Peoples R China
3.Peking Univ, Dept Urol, Hosp 1, Beijing 100034, Peoples R China

Recommended Citation:
Xu, Yongde,Lei, Hongen,Guan, Ruili,et al. Studies on the mechanism of testicular dysfunction in the early stage of a streptozotocin induced diabetic rat model[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2014,450(1):87-92.
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