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Extraction, Separation, Detection, and Structural Analysis of Flavonoids
Qiao, Xue; Yang, Wen-zhi; Guo, De-an; Ye, Min
关键词Flavonoids Hplc Lc/ms Separation Detection Structural Analysis Medicinal And Dietary Herb
刊名CURRENT ORGANIC CHEMISTRY
2011-08-01
15期:15页:2541-2566
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Organic
研究领域[WOS]Chemistry
关键词[WOS]TANDEM MASS-SPECTROMETRY ; PERFORMANCE LIQUID-CHROMATOGRAPHY ; MICROWAVE-ASSISTED EXTRACTION ; PRESSURE CHEMICAL-IONIZATION ; SOLID-PHASE EXTRACTION ; HYDROPHILIC INTERACTION CHROMATOGRAPHY ; SAMPLE PREPARATION METHOD ; SAUSSUREA-MEDUSA MAXIM ; DIODE-ARRAY DETECTOR ; ELECTROSPRAY-IONIZATION
英文摘要

Flavonoids, as an important class of natural products, are the main bioactive constituents of a lot of medicinal or dietary plants. They have been reported to show extensive benefits to human health, including antioxidant, anti-inflammatory, and anti-cancer activities. In most cases, flavonoids are present in plants as a series of analogues with similar structures and physico-chemical properties. This chemical complexity renders the quality control of flavonoid-containing herbal products problematic. Therefore, rapid, accurate and sensitive analytical techniques for flavonoids are of significance. This review summarizes the advances in sample extraction, chromatographic separation, detection, and structural analysis of flavonoids in medicinal and dietary herbs since 2005. Emphasis will be put on the qualitative and quantitative analysis of flavonoids in botanical extracts by high-performance liquid chromatography (HPLC) and liquid chromatography coupled with mass spectrometry (LC/MS). New techniques like UPLC, HILIC, and 2D-HPLC have significantly improved the separation capabilities of HPLC. The versatile LC/MS does not only allow fast and accurate structural analysis of flavonoids in complicated mixtures, but also provides a rapid and sensitive technique for the quantitative detection of flavonoids in herbal extracts and even in biological matrices. These techniques will be widely used for the chemical analysis of flavonoids and for the quality control of related herbal products.

语种英语
WOS记录号WOS:000293852000002
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54203
专题北京大学药学院
北京大学药学院_天然药物学系
作者单位Peking Univ, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Qiao, Xue,Yang, Wen-zhi,Guo, De-an,et al. Extraction, Separation, Detection, and Structural Analysis of Flavonoids[J]. CURRENT ORGANIC CHEMISTRY,2011,15(15):2541-2566.
APA Qiao, Xue,Yang, Wen-zhi,Guo, De-an,&Ye, Min.(2011).Extraction, Separation, Detection, and Structural Analysis of Flavonoids.CURRENT ORGANIC CHEMISTRY,15(15),2541-2566.
MLA Qiao, Xue,et al."Extraction, Separation, Detection, and Structural Analysis of Flavonoids".CURRENT ORGANIC CHEMISTRY 15.15(2011):2541-2566.
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