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学科主题: 药学
题名:
Extraction, Separation, Detection, and Structural Analysis of Flavonoids
作者: Qiao, Xue; Yang, Wen-zhi; Guo, De-an; Ye, Min
关键词: Flavonoids ; HPLC ; LC/MS ; separation ; detection ; structural analysis ; medicinal and dietary herb
刊名: CURRENT ORGANIC CHEMISTRY
发表日期: 2011-08-01
卷: 15, 期:15, 页:2541-2566
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Organic
研究领域[WOS]: Chemistry
关键词[WOS]: TANDEM MASS-SPECTROMETRY ; PERFORMANCE LIQUID-CHROMATOGRAPHY ; MICROWAVE-ASSISTED EXTRACTION ; PRESSURE CHEMICAL-IONIZATION ; SOLID-PHASE EXTRACTION ; HYDROPHILIC INTERACTION CHROMATOGRAPHY ; SAMPLE PREPARATION METHOD ; SAUSSUREA-MEDUSA MAXIM ; DIODE-ARRAY DETECTOR ; ELECTROSPRAY-IONIZATION
英文摘要:

Flavonoids, as an important class of natural products, are the main bioactive constituents of a lot of medicinal or dietary plants. They have been reported to show extensive benefits to human health, including antioxidant, anti-inflammatory, and anti-cancer activities. In most cases, flavonoids are present in plants as a series of analogues with similar structures and physico-chemical properties. This chemical complexity renders the quality control of flavonoid-containing herbal products problematic. Therefore, rapid, accurate and sensitive analytical techniques for flavonoids are of significance. This review summarizes the advances in sample extraction, chromatographic separation, detection, and structural analysis of flavonoids in medicinal and dietary herbs since 2005. Emphasis will be put on the qualitative and quantitative analysis of flavonoids in botanical extracts by high-performance liquid chromatography (HPLC) and liquid chromatography coupled with mass spectrometry (LC/MS). New techniques like UPLC, HILIC, and 2D-HPLC have significantly improved the separation capabilities of HPLC. The versatile LC/MS does not only allow fast and accurate structural analysis of flavonoids in complicated mixtures, but also provides a rapid and sensitive technique for the quantitative detection of flavonoids in herbal extracts and even in biological matrices. These techniques will be widely used for the chemical analysis of flavonoids and for the quality control of related herbal products.

语种: 英语
所属项目编号: 985-2-119-121
项目资助者: Peking University Health Science Center
WOS记录号: WOS:000293852000002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54203
Appears in Collections:北京大学药学院_期刊论文

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作者单位: Peking Univ, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100191, Peoples R China

Recommended Citation:
Qiao, Xue,Yang, Wen-zhi,Guo, De-an,et al. Extraction, Separation, Detection, and Structural Analysis of Flavonoids[J]. CURRENT ORGANIC CHEMISTRY,2011,15(15):2541-2566.
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