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学科主题: 药学
题名:
Dynamic Changes in Phenotypic Groups in Patients with Stable Angina Pectoris after Treatment with Xinxuekang Capsule: A Randomized Controlled Trial
作者: Wang, Li-Ying1; Tang, Jian-Yuan2; Liu, Jun1; Lu, Wei3; Yu, Ya-Nan1; Chen, Bi-Wei4; Wu, Hong-Li1; Su, Li-Ya1; Jing, Zhi-Wei1; Hu, Si-Yuan5; Liu, Xiang-Ling5; Yang, Xi-Yan5; Li, Guo-Xin6; Dong, Bo6; Wang, Dong-Hai6; Xue, Jie7; Wang, Xiao-Feng7; Li, Zhuo-Ming8; Liu, Shu-Rong8; Liu, Song-Shan9; Chen, Qi-guang4; Zhang, Lei10; Wang, Zhong1; Shen, Chun-Ti11; Wang, Yong-Yan1
关键词: Stable angina pectoris ; similarity degree analysis ; nonlinear mixed effect model ; treatment effectiveness
刊名: CURRENT VASCULAR PHARMACOLOGY
发表日期: 2015
卷: 13, 期:4, 页:492-503
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy ; Peripheral Vascular Disease
研究领域[WOS]: Pharmacology & Pharmacy ; Cardiovascular System & Cardiology
关键词[WOS]: OBSTRUCTIVE PULMONARY-DISEASE ; HUMAN PHENOME ; THERAPY ; ALGORITHM ; TARGETS ; CELLS ; RATS
英文摘要:

Objective: To reveal the cutoff point and influencing factors in the dynamic change in phenotypic group in patients with stable angina pectoris (SAP) after Xinxuekang capsule treatment.

Methods: Five hundred and seventy-six SAP patients were randomly assigned to receive Xinxuekang (XXK) capsules or Compound Danshen (CDS) tablets for 8 weeks. Global similarity degree analysis and nonlinear mixed effects modeling (NONMEM) were employed to reveal the cutoff points and influencing factors in dynamic changes in the SAP phenotypic group. The phenotypic group was defined as the six phenotypes in SAP, including angina, choking sensation in the chest, palpitations, dark purple lips, ecchymosis on the tongue, and fine-choppy pulse, which were quantitatively evaluated on Days 0, 14, 28, 42, and 56.

Results: Variation in the six individual phenotypes and distribution of the SAP phenotypic profile were similar between the two experimental groups, but cutoff points for changes in the SAP phenotypic group were 7.28 and 10.73 weeks in XXK and CDS groups, respectively. Degree of severity of SAP as well as study site significantly affected the tendency for change in the SAP Xueyu Zheng in both XXK and CDS treatment groups. Different Chinese patent drugs affected the tendency for change in phenotypic group in patients with SAP. XXK was superior to CDS in controlling a clinical phenotypic group.

Conclusion: Based on global similarity degree analysis and NONMEM, the cutoff point and influencing factors in phenomic variation of SAP may be determined, to improve the development and modification of treatment regimens.

语种: 英语
所属项目编号: Z0173 ; Z0197 ; 2013ZX09303301 ; 201207009
项目资助者: China Academy of Chinese Medical Sciences ; National Science and Technology Major Project ; State Administration of Traditional Chinese Medicine
WOS记录号: WOS:000358868200009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54204
Appears in Collections:北京大学药学院_药剂学系_期刊论文

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作者单位: 1.State Food & Drug Adm, Ctr Drug Evaluat, Beijing 100053, Peoples R China
2.Changzhou TCM Hosp, Changzhou 213004, Jiangsu, Peoples R China
3.China Acad Chinese Med Sci, Inst Basic Res Clin Med, Beijing 100700, Peoples R China
4.Peking Univ, Sch Pharmaceut Sci, Dept Pharmaceut, Hlth Sci Ctr, Beijing 100083, Peoples R China
5.Southeast Univ, Sch Publ Hlth, Nanjing 210009, Jiangsu, Peoples R China
6.Tianjin Univ Tradit Chinese Med, Teaching Hosp 1, Tianjin 300193, Peoples R China
7.Liaoning Univ TCM, Hosp 2, Shenyang 110034, Liaoning, Peoples R China
8.TCM Hosp Xinjiang Uygur Autonomous Region, Urumqi 830099, Xinjiang, Peoples R China
9.Jilin Prov Hosp Integrated TCM & Western Med, Changchun 130021, Jilin, Peoples R China
10.Chengdu Univ Tradit Chinese Med, Affiliated Hosp, Chengdu 610075, Sichuan, Peoples R China
11.Shanghai Univ Tradit Chinese Med, Shanghai 201203, Peoples R China

Recommended Citation:
Wang, Li-Ying,Tang, Jian-Yuan,Liu, Jun,et al. Dynamic Changes in Phenotypic Groups in Patients with Stable Angina Pectoris after Treatment with Xinxuekang Capsule: A Randomized Controlled Trial[J]. CURRENT VASCULAR PHARMACOLOGY,2015,13(4):492-503.
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