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学科主题基础医学
Higher levels of circulating monocyte-platelet aggregates are correlated with viremia and increased sCD163 levels in HIV-1 infection
Liang, Hua1; Duan, Zhaojun2; Li, Dan1; Li, Dongliang3; Wang, Zheng1; Ren, Li1; Shen, Tao2; Shao, Yiming1
关键词HIV-1 immune activation monocytes platelets sCD163
刊名CELLULAR & MOLECULAR IMMUNOLOGY
2015-07-01
DOI10.1038/cmi.2014.66
12期:4页:435-443
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Immunology
研究领域[WOS]Immunology
关键词[WOS]HUMAN-IMMUNODEFICIENCY-VIRUS ; ACUTE MYOCARDIAL-INFARCTION/ ; TOLL-LIKE RECEPTORS ; SURFACE P-SELECTIN ; SOLUBLE CD163 ; DISEASE PROGRESSION ; ANTIRETROVIRAL THERAPY ; PLASMA-LEVELS ; TISSUE FACTOR ; ACTIVATION
英文摘要

Increased levels of monocyte-platelet aggregates (MPAs) are reported to be highly correlated with cardiovascular events. In this study, the MPA levels in different monocyte subsets and the associations between MPA levels, HIV-1 viremia and monocyte activation were evaluated during HIV-1 infection. The results showed that the percentages of MPAs in all three monocyte subsets were higher in HIV-1-infected subjects than in healthy controls, and were associated with the plasma viral load in the non-classical and intermediate monocyte subsets. The plasma levels of sCD14 and sCD163 were upregulated in HIV-1 infection and were positively associated with viral loads and negatively associated with CD4 counts. P-selectin glycoprotein ligand-1 (PSGL-1) was shown to be expressed at significantly lower levels on all three monocyte subsets and was negatively correlated with the sCD163 level. The MPA level was correlated with the levels of plasma sCD163 but negatively correlated with CD163 and PSGL-1 on all three monocyte subsets. An elevated immune activation status was correlated with increased MPA formation, underlying the potential interaction between monocyte activation and MPA formation. This interaction may be related to a higher thromboembolic risk in patients infected with HIV-1.

语种英语
WOS记录号WOS:000360939000006
项目编号31100126 ; 81271826 ; 81020108030 ; 81101281 ; 2011SKLID207 ; 2012SKLID103 ; 2012ZX10001008 ; 2014ZX10001001-002 ; 7122108
资助机构National Natural Science Foundation of China ; SKLID ; China National Major Projects for Infectious Diseases Control and Prevention ; Beijing Natural Science Foundation
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54205
专题北京大学基础医学院_病原生物学系
北京大学基础医学院
作者单位1.Collaborat Innovat Ctr Diag & Treatment Infect Di, Natl Ctr AIDS STD Control & Prevent, State Key Lab Infect Dis Prevent & Control, China CDC, Beijing, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Dept Microbiol, Beijing 100191, Peoples R China
3.Beijing Chaoyang Dist Ctr Dis Control & Prevent, Beijing, Peoples R China
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GB/T 7714
Liang, Hua,Duan, Zhaojun,Li, Dan,et al. Higher levels of circulating monocyte-platelet aggregates are correlated with viremia and increased sCD163 levels in HIV-1 infection[J]. CELLULAR & MOLECULAR IMMUNOLOGY,2015,12(4):435-443.
APA Liang, Hua.,Duan, Zhaojun.,Li, Dan.,Li, Dongliang.,Wang, Zheng.,...&Shao, Yiming.(2015).Higher levels of circulating monocyte-platelet aggregates are correlated with viremia and increased sCD163 levels in HIV-1 infection.CELLULAR & MOLECULAR IMMUNOLOGY,12(4),435-443.
MLA Liang, Hua,et al."Higher levels of circulating monocyte-platelet aggregates are correlated with viremia and increased sCD163 levels in HIV-1 infection".CELLULAR & MOLECULAR IMMUNOLOGY 12.4(2015):435-443.
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