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学科主题: 基础医学
题名:
Higher levels of circulating monocyte-platelet aggregates are correlated with viremia and increased sCD163 levels in HIV-1 infection
作者: Liang, Hua1; Duan, Zhaojun2; Li, Dan1; Li, Dongliang3; Wang, Zheng1; Ren, Li1; Shen, Tao2; Shao, Yiming1
关键词: HIV-1 ; immune activation ; monocytes ; platelets ; sCD163
刊名: CELLULAR & MOLECULAR IMMUNOLOGY
发表日期: 2015-07-01
DOI: 10.1038/cmi.2014.66
卷: 12, 期:4, 页:435-443
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Immunology
研究领域[WOS]: Immunology
关键词[WOS]: HUMAN-IMMUNODEFICIENCY-VIRUS ; ACUTE MYOCARDIAL-INFARCTION/ ; TOLL-LIKE RECEPTORS ; SURFACE P-SELECTIN ; SOLUBLE CD163 ; DISEASE PROGRESSION ; ANTIRETROVIRAL THERAPY ; PLASMA-LEVELS ; TISSUE FACTOR ; ACTIVATION
英文摘要:

Increased levels of monocyte-platelet aggregates (MPAs) are reported to be highly correlated with cardiovascular events. In this study, the MPA levels in different monocyte subsets and the associations between MPA levels, HIV-1 viremia and monocyte activation were evaluated during HIV-1 infection. The results showed that the percentages of MPAs in all three monocyte subsets were higher in HIV-1-infected subjects than in healthy controls, and were associated with the plasma viral load in the non-classical and intermediate monocyte subsets. The plasma levels of sCD14 and sCD163 were upregulated in HIV-1 infection and were positively associated with viral loads and negatively associated with CD4 counts. P-selectin glycoprotein ligand-1 (PSGL-1) was shown to be expressed at significantly lower levels on all three monocyte subsets and was negatively correlated with the sCD163 level. The MPA level was correlated with the levels of plasma sCD163 but negatively correlated with CD163 and PSGL-1 on all three monocyte subsets. An elevated immune activation status was correlated with increased MPA formation, underlying the potential interaction between monocyte activation and MPA formation. This interaction may be related to a higher thromboembolic risk in patients infected with HIV-1.

语种: 英语
所属项目编号: 31100126 ; 81271826 ; 81020108030 ; 81101281 ; 2011SKLID207 ; 2012SKLID103 ; 2012ZX10001008 ; 2014ZX10001001-002 ; 7122108
项目资助者: National Natural Science Foundation of China ; SKLID ; China National Major Projects for Infectious Diseases Control and Prevention ; Beijing Natural Science Foundation
WOS记录号: WOS:000360939000006
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54205
Appears in Collections:基础医学院_病原生物学系_期刊论文

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作者单位: 1.Collaborat Innovat Ctr Diag & Treatment Infect Di, Natl Ctr AIDS STD Control & Prevent, State Key Lab Infect Dis Prevent & Control, China CDC, Beijing, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Dept Microbiol, Beijing 100191, Peoples R China
3.Beijing Chaoyang Dist Ctr Dis Control & Prevent, Beijing, Peoples R China

Recommended Citation:
Liang, Hua,Duan, Zhaojun,Li, Dan,et al. Higher levels of circulating monocyte-platelet aggregates are correlated with viremia and increased sCD163 levels in HIV-1 infection[J]. CELLULAR & MOLECULAR IMMUNOLOGY,2015,12(4):435-443.
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