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学科主题: 临床医学
题名:
Elevated Preoperative Carcinoembryonic Antigen (CEA) and Ki67 Is Predictor of Decreased Survival in IIA Stage Colon Cancer
作者: Peng, Yifan1,2; Wang, Lin1,2; Gu, Jin1,2
刊名: WORLD JOURNAL OF SURGERY
发表日期: 2013
DOI: 10.1007/s00268-012-1814-7
卷: 37, 期:1, 页:208-213
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Surgery
研究领域[WOS]: Surgery
关键词[WOS]: INDEPENDENT PROGNOSTIC-FACTOR ; COLORECTAL-CANCER ; ADJUVANT CHEMOTHERAPY ; GASTROINTESTINAL CANCER ; THYMIDYLATE SYNTHASE ; CURATIVE RESECTION ; HIGH-RISK ; DUKES-B ; EXPRESSION ; MARKERS
英文摘要:

The present study was designed to investigate the prognostic factors of stage IIA (pT3N0M0) colon cancer.

We retrospectively reviewed consecutive patients with stage IIA colon cancer treated with curative surgery alone from January 2004 to June 2008 in Peking University Cancer Hospital. Patient demographics, and clinical, histopathologic, and laboratory data were analyzed. Univariate and multivariate analyses were carried out to identify prognostic factors associated with 3-year disease-free survival (DFS).

For the 84 valid cases reviewed in this study, the 3-year DFS was 88.1 %. That for a group with elevated CEA was 77.1 % and for a group with a normal CEA level, it was 95.9 %, with statistical difference (p = 0.007). Multivariate analysis demonstrated that CEA level (p = 0.012, OR = 8.013, 1.573-40.817), expression of Ki67 (p = 0.099, OR = 3.298, 0.799-3.610), male gender (p = 0.024, OR = 7.212, 1.293-40.237), and anemia (p = 0.011, OR = 6.461, 1.537-27.151) were the independent prognostic factors for 3-year DFS. Stratified analysis revealed that an elevated CEA level combined with high expression of Ki67 was associated with poorer prognosis (3-year DFS 70 %).

An elevated preoperative serum level of CEA and high expression of Ki67 in tumor tissue were predictors of poor prognosis for patients with stage IIA colon cancer. These patients should therefore be considered candidates for receiving intensive surveillance. Future clinical trials using multicenter patient cohorts should be prospectively performed to evaluate whether these high-risk patients could benefit from adjuvant chemotherapy to improve prognosis.

语种: 英语
WOS记录号: WOS:000312808400029
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54209
Appears in Collections:北京大学临床肿瘤学院_胃肠肿瘤中心_期刊论文

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作者单位: 1.Beijing Canc Hosp, Peking Univ Canc Hosp Inst, Dept Colorectal Surg, Key Lab Carcinogenesis & Translat Res Minist Educ, Beijing, Peoples R China
2.Peking Univ, Canc Hosp & Inst, Beijing Canc Hosp,Minist Educ, Dept Colorectal Surg,Key Lab Carcinogenesis & Tra, Beijing 100871, Peoples R China

Recommended Citation:
Peng, Yifan,Wang, Lin,Gu, Jin. Elevated Preoperative Carcinoembryonic Antigen (CEA) and Ki67 Is Predictor of Decreased Survival in IIA Stage Colon Cancer[J]. WORLD JOURNAL OF SURGERY,2013,37(1):208-213.
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