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学科主题: 基础医学
题名:
A New Specialization in Astrocytes: Glutamate- and Ammonia-Induced Nuclear Size Changes
作者: Yang, Chun Zhang1; Li, Hui Li1; Zhou, Ye1; Chai, Rui Chao1; Zhao, Rui1; Dong, Yan1; Xu, Zhen Yu1; Lau, Lok Ting1; Zhang Yingge2; Teng, Junlin3; Chen, Jianguo3,4; Yu, Albert Cheung Hoi1,5,6
关键词: astrocyte ; nuclear swelling ; cytoplasmic swelling ; glutamate ; ammonia ; atomic force microscopy
刊名: JOURNAL OF NEUROSCIENCE RESEARCH
发表日期: 2011-12-01
DOI: 10.1002/jnr.22657
卷: 89, 期:12, 页:2041-2051
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: MESSENGER-RNA EXPRESSION ; NECROSIS-FACTOR-ALPHA ; GLIAL-CELLS ; HEPATIC-ENCEPHALOPATHY ; SYNAPTIC-TRANSMISSION ; WATER PERMEABILITY ; XENOPUS OOCYTES ; MECHANISMS ; TRANSPORT ; CYTOSKELETON
英文摘要:

We observed nuclear swelling in glutamate (Glu)-treated astrocytes that was concomitant with but independent of astrocytic cell swelling. We confirmed Glu-induced nuclear swelling with nuclei isolated from astrocytes. Ammonia is metabolically related to Glu and could induce a nuclear swelling in intact astrocytes but shrinkage in isolated nuclei. Other compounds such as glutamine, aspartate, taurine, glycine, and ATP did not cause any nuclear swelling in isolated nuclei of astrocytes. Surprisingly, Glu and ammonia did not induce nuclear swelling in microglia, C6, HEK 293, or Hep G2 cell lines in cultures and their isolated nuclei. The Glu- and ammonia-induced nuclear size changes appear to be a specific response of astrocytes to these two closely related metabolic compounds. (C) 2011 Wiley-Liss, Inc.

语种: 英语
所属项目编号: 30270426 ; 30470543 ; 30670644 ; 30870818 ; 31070974 ; 7032026 ; 7051004 ; 7091004 ; 2006AA02Z452 ; 2011CB504400
项目资助者: National Natural Science Foundation of China ; Beijing Natural Science Foundation ; National High Technology Research and Development Program of China (863 Program) ; National Basic Research Program of China (973 Program)
WOS记录号: WOS:000296420400017
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54210
Appears in Collections:基础医学院_神经生物学系_期刊论文

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作者单位: 1.Peking Univ, Neurosci Res Inst, Sch Basic Med Sci,Hlth Sci Ctr, Key Lab Neurosci,Minist Educ,Minist Publ Hlth,Dep, Beijing 100191, Peoples R China
2.Beijing Inst Pharmacol & Toxicol, Beijing, Peoples R China
3.Peking Univ, Key Lab Cell Proliferat & Differentiat, State Key Lab Biomembrane & Membrane Bioengn, Coll Life Sci,Minist Educ, Beijing 100191, Peoples R China
4.Peking Univ, Ctr Theoret Biol, Beijing 100191, Peoples R China
5.Peking Univ, Ctr Infect Dis, Beijing 100191, Peoples R China
6.Peking Univ, Lab Translat Med, Inst Syst Biomed, Beijing 100191, Peoples R China

Recommended Citation:
Yang, Chun Zhang,Li, Hui Li,Zhou, Ye,et al. A New Specialization in Astrocytes: Glutamate- and Ammonia-Induced Nuclear Size Changes[J]. JOURNAL OF NEUROSCIENCE RESEARCH,2011,89(12):2041-2051.
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文件名: A New Specialization in Astrocytes Glutamate- and Ammonia-Induced Nuclear Size Changes.pdf
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