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学科主题: 药学
题名:
Identification of xanthones from Swertia punicea using high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry
作者: Du, Xin-Gang1,2; Wang, Wei3,4; Zhang, Qing-Ying2; Cheng, Jun5; Avula, Bharathi6; Khan, Ikhlas A.6; Guo, De-An1
刊名: RAPID COMMUNICATIONS IN MASS SPECTROMETRY
发表日期: 2012-12-30
DOI: 10.1002/rcm.6419
卷: 26, 期:24, 页:2913-2923
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemical Research Methods ; Chemistry, Analytical ; Spectroscopy
研究领域[WOS]: Biochemistry & Molecular Biology ; Chemistry ; Spectroscopy
关键词[WOS]: JAPONICA MAKINO ; 3-O-DEMETHYLSWERTIPUNICOSIDE ; FRANCHETIANA ; GENTIANELLA ; GLUCOSIDES ; GLYCOSIDES
英文摘要:

RATIONALE Swertia punicea Hemsl. (Gentianaceae) are used mainly for the treatment of acute bilious hepatitis, cholecystitis, fever, intoxification and jaundice in China, as a traditional Chinese folk medicine. Xanthones as the main chemical components of Swertia punicea have many possible pharmacological properties, such as hepatoprotective and anti-HIV. In order to obtain an overall picture of the xanthones of Swertia punicea, high-performance liquid chromatography diode-array detection/tandem mass spectrometry (HPLC/DAD-ESI-MSn) was applied to the structural characterization of xanthones in ethyl acetate and acetone extracts. METHODS The ESI-MS fragmentation behaviors of xanthones were investigated based on the 17 reference xanthones and then applied to the structural characterization of xanthones in ethyl acetate and acetone extracts of Swertia punicea by HPLC/DAD-ESI-MSn. RESULTS The fragmentation rules of aglycone, C-glycosides, O-glycosides, and polyxanthones with different linkages were summarized. The observed fragmentation pathways were used successfully for the analysis of the xanthone constituents of Swertia punicea, and a total of 34 xanthones were identified, among which 16 compounds were new and one compound was reported from this species for the first time. CONCLUSIONS The described methods were very valuable for the identification of xanthones, especially of the trace compounds, and therefore could be utilized for sensitive and rapid qualitative analysis of xanthones in Swertia punicea. Copyright (C) 2012 John Wiley & Sons, Ltd.

语种: 英语
所属项目编号: 985-2-063-112 ; 104218
项目资助者: Program for Changjiang Scholar and Innovative Team in University ; Cultivation Fund of the Key Scientific and Technical Innovation Project, Ministry of Education of China
WOS记录号: WOS:000310872500008
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54211
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai 201203, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
3.Hunan Univ Chinese Med, Sch Pharm, TCM, Changsha 410208, Hunan, Peoples R China
4.Hunan Univ Chinese Med, Sch Pharm, Ethnomed Innovat & Dev Lab, Changsha 410208, Hunan, Peoples R China
5.China Agr Univ, Key Lab Urban Agr N, Minist Agr, Beijing 102206, Peoples R China
6.Univ Mississippi, Pharmaceut Sci Res Inst, Natl Ctr Nat Prod Res, University, MS 38677 USA

Recommended Citation:
Du, Xin-Gang,Wang, Wei,Zhang, Qing-Ying,et al. Identification of xanthones from Swertia punicea using high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry[J]. RAPID COMMUNICATIONS IN MASS SPECTROMETRY,2012,26(24):2913-2923.
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