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Metabolic regulatory effects of licorice: A bile acid metabonomic study by liquid chromatography coupled with tandem mass spectrometry
Qiao, Xue1; Ye, Min1; Xiang, Cheng1; Bo, Tao2; Yang, Wen-zhi1; Liu, Chun-fang1; Miao, Wen-juan1; Guo, De-an1
关键词Bile Acid Metabonomics Lc/ms/ms Licorice Glycyrrhiza Uralensis Metabolic Regulation
刊名STEROIDS
2012-06-01
DOI10.1016/j.steroids.2012.03.016
77期:7页:745-755
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Endocrinology & Metabolism
资助者National Natural Science Foundation of China ; China Ministry of Education ; National Natural Science Foundation of China ; China Ministry of Education
研究领域[WOS]Biochemistry & Molecular Biology ; Endocrinology & Metabolism
关键词[WOS]CHEMICAL-SYNTHESIS ; BIOLOGICAL-FLUIDS ; NUCLEAR RECEPTORS ; RAT ; PATHWAYS ; LIVER ; TRANSPORTERS ; URINE
英文摘要

Licorice is one of the most popular herbal medicines worldwide, and is mainly used to moderate the characteristics of other herbs in Traditional Chinese Medicine. It is hypothesized that licorice exerts this role by regulating systemic metabolism. Bile acids play a critical role in lipid digestion and cholesterol metabolism, and are sensitive biomarkers for hepatic function. In this study, the regulatory effects of licorice on bile acid metabonome in rats were investigated using liquid chromatography coupled with tandem mass spectrometry. After oral administration of a clinical dosage of licorice water extract, the levels of 21 fully identified and 41 tentatively characterized bile acid analogs in rat plasma were determined by a fully validated method. Following partial least squares discriminant analysis, the results showed that licorice treatment led to dose-dependent up-regulation of free and glycine-conjugated bile acids excretion. Particularly, the plasma levels of cholic acid (1465.33 +/- 915.93-7156.46 +/- 3490.49 ng/mL, p = 0.0027) and beta-muricholic acid (228.19 +/- 163.95-1284.40 +/- 775.62 ng/mL, p = 0.0045) increased significantly 48 h after administration. As licorice is widely used as a detoxifying drug, the regulation of plasma bile acids may be an important evidence to interpret its mechanism. (C) 2012 Elsevier Inc. All rights reserved.

语种英语
所属项目编号81173644 ; BMU20110269
资助者National Natural Science Foundation of China ; China Ministry of Education ; National Natural Science Foundation of China ; China Ministry of Education
WOS记录号WOS:000305264500005
Citation statistics
Cited Times:13[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54212
Collection北京大学药学院
作者单位1.Agilent Technol, Beijing 100102, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
Recommended Citation
GB/T 7714
Qiao, Xue,Ye, Min,Xiang, Cheng,et al. Metabolic regulatory effects of licorice: A bile acid metabonomic study by liquid chromatography coupled with tandem mass spectrometry[J]. STEROIDS,2012,77(7):745-755.
APA Qiao, Xue.,Ye, Min.,Xiang, Cheng.,Bo, Tao.,Yang, Wen-zhi.,...&Guo, De-an.(2012).Metabolic regulatory effects of licorice: A bile acid metabonomic study by liquid chromatography coupled with tandem mass spectrometry.STEROIDS,77(7),745-755.
MLA Qiao, Xue,et al."Metabolic regulatory effects of licorice: A bile acid metabonomic study by liquid chromatography coupled with tandem mass spectrometry".STEROIDS 77.7(2012):745-755.
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