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学科主题: 临床医学
题名:
Overexpression of Cyclooxygenase-1 Correlates with Poor Prognosis in Renal Cell Carcinoma
作者: Yu, Zu-Hu1,2,3; Zhang, Qiang1,2,3; Wang, Ya-Dong1,2,3; Chen, Jing2; Jiang, Zhi-Mao2; Shi, Min2; Guo, Xin2; Qin, Jie2; Cui, Guang-Hui2; Cai, Zhi-Ming2; Gui, Yao-Ting2; Lai, Yong-Qing1,2
关键词: Cyclooxygenase-1 ; renal cell carcinoma ; prognostic marker
刊名: ASIAN PACIFIC JOURNAL OF CANCER PREVENTION
发表日期: 2013
DOI: 10.7314/APJCP.2013.14.6.3729
卷: 14, 期:6, 页:3729-3734
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: MOLECULAR MARKERS ; CANCER STATISTICS ; TUMOR PROGRESSION ; EXPRESSION ; THERAPY ; PROTEIN ; RECURRENCE ; PREDICTOR ; DIAGNOSIS ; SURVIVAL
英文摘要:

The aim of this study was to evaluate expression of COX-1 in renal cell carcinoma (RCC) and its prognostic value. mRNA of COX-1 was detected in 42 paired RCC and adjacent normal tissues with quantitative real-time polymerase chain reaction (qRT-PCR). Expression of COX-1 was also evaluated in 196 RCC sections and 91 adjacent normal tissues with immunohistochemistry. Statistical analysis was performed to assess COX-1 expression in RCC and its prognostic significance. The results of qRT-PCR showed mRNA levels of COX-1 in RCC tissues to be significantly higher than that in adjacent normal tissues (p < 0.001). Immunohistochemical assays also revealed COX-1 to be overexpressed in RCC tissues (p < 0.001). Statistical analysis demonstrated high expression of COX-1 was correlated with tumour size (p = 0.002), pathological stage (p = 0.003), TNM stage (p = 0.003, 0.007, 0.027, respectively), and tumour recurrence (p < 0.001). Survival analysis indicated patients with high expression of COX-1 had shorter survival time (p < 0.001), and COX-1 was an independent predictor. This is the first study to reveal overexpression of COX-1 in RRC and point to use as a prognostic marker in affected patients.

语种: 英语
所属项目编号: 81101922 ; A2012584
项目资助者: National Natural Science Foundation of China ; Medical Scientific Research Foundation of Guangdong Province of China
WOS记录号: WOS:000331517700058
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54215
Appears in Collections:北京大学深圳医院_泌尿外科_期刊论文

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作者单位: 1.Anhui Med Univ, Hefei, Anhui, Peoples R China
2.Peking Univ, Shenzhen Hosp, Dept Urol, Shenzhen, Peoples R China
3.Peking Univ, Shenzhen Hosp, Inst Urol,Shenzhen PKU HKUST Med Ctr, Guangdong & Shenzhen Key Lab Male Reprod Med & Ge, Shenzhen, Peoples R China

Recommended Citation:
Yu, Zu-Hu,Zhang, Qiang,Wang, Ya-Dong,et al. Overexpression of Cyclooxygenase-1 Correlates with Poor Prognosis in Renal Cell Carcinoma[J]. ASIAN PACIFIC JOURNAL OF CANCER PREVENTION,2013,14(6):3729-3734.
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