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Gadolinium-induced oxidative stress triggers endoplasmic reticulum stress in rat cortical neurons
Xia, Qing1; Feng, Xudong; Huang, Haifeng; Du, Lingyan; Yang, Xiaoda; Wang, Kui
关键词Endoplasmic Reticulum Stress Gadolinium Neurotoxicity Oxidative Stress
刊名JOURNAL OF NEUROCHEMISTRY
2011-04-01
DOI10.1111/j.1471-4159.2010.07162.x
117期:1页:38-47
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Neurosciences
研究领域[WOS]Biochemistry & Molecular Biology ; Neurosciences & Neurology
关键词[WOS]UNFOLDED-PROTEIN RESPONSE ; NEPHROGENIC SYSTEMIC FIBROSIS ; CELL-DEATH ; ER STRESS ; INDUCED APOPTOSIS ; CALCIUM HOMEOSTASIS ; NEUROTROPHIC FACTOR ; IN-VIVO ; ALUMINUM ; BRAIN
英文摘要

P>Introduction of Gadolinium (Gd) to the nervous system is linked to the development of neurotoxicity involving both oxidative and endoplasmic reticulum (ER) stress. Gd levels (0.2-20 mu m) in the form of gadolinium trichloride (GdCl(3)) cause neurotoxicity in vitro. We investigated the signaling pathways in primary cultured rat cortical neurons and tested whether GdCl(3) induced oxidative and ER stress. Results showed that Gd-induced neural cell death followed a rapid accumulation of intracellular reactive oxygen species. In addition, Gd exposure resulted in spliced X-box binding protein 1 mRNA and increased expression of binding immunoglobulin protein, thus activating transcription factor 4 (ATF4), ATF6, and C/EBP homologous protein mRNA. Up-regulated expression of binding immunoglobulin protein is a hallmark of ER stress and C/EBP homologous protein is an ER stress-related pro-apoptotic transcription factor. Activation of ER stress downstream substrates, inositol-requiring kinase 1 and ATF6, was also observed in Gd-treated cells. The neurotoxic effects of Gd were blocked by the antioxidant N-acetylcysteine. Results demonstrated that Gd-induced cytotoxicity in neurons occurs via oxidative injury and ER stress-related signal transduction, thus offering new insight into the neurotoxicology of gadolinium.

语种英语
WOS记录号WOS:000288264300004
项目编号20901005 ; 20637010
资助机构National Natural Science Foundation of China
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被引频次:33[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54216
专题北京大学药学院_化学生物学系
作者单位1.Peking Univ, Hlth Sci Ctr, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Biol Chem, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
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GB/T 7714
Xia, Qing,Feng, Xudong,Huang, Haifeng,et al. Gadolinium-induced oxidative stress triggers endoplasmic reticulum stress in rat cortical neurons[J]. JOURNAL OF NEUROCHEMISTRY,2011,117(1):38-47.
APA Xia, Qing,Feng, Xudong,Huang, Haifeng,Du, Lingyan,Yang, Xiaoda,&Wang, Kui.(2011).Gadolinium-induced oxidative stress triggers endoplasmic reticulum stress in rat cortical neurons.JOURNAL OF NEUROCHEMISTRY,117(1),38-47.
MLA Xia, Qing,et al."Gadolinium-induced oxidative stress triggers endoplasmic reticulum stress in rat cortical neurons".JOURNAL OF NEUROCHEMISTRY 117.1(2011):38-47.
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