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学科主题临床医学
Decreased FOXD3 Expression Is Associated with Poor Prognosis in Patients with High-Grade Gliomas
Du, Wei1; Pang, Changhe1; Wang, Dongliang2; Zhang, Qingjun2; Xue, Yake1; Jiao, Hongliang1; Zhan, Lei3; Ma, Qian4; Wei, Xinting1
刊名PLOS ONE
2015-05-26
DOI10.1371/journal.pone.0127976
10期:5
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]CHRONIC LYMPHOCYTIC-LEUKEMIA ; TRANSCRIPTION FACTOR FOXD3 ; GASTRIC CARCINOGENESIS ; TUMOR-SUPPRESSOR ; MELANOMA-CELLS ; MURINE MODEL ; CANCER ; PROGRESSION ; REQUIREMENT ; DISEASE
英文摘要

Background

The transcription factor forkhead box D3 (FOXD3) plays important roles in the development of neural crest and has been shown to suppress the development of various cancers. However, the expression and its potential biological roles of FOXD3 in high-grade gliomas (HGGs) remain unknown.

Methods

The mRNA and protein expression levels of FOXD3 were examined using real-time quantitative PCR and western blotting in 23 HGG and 13 normal brain samples, respectively. Immunohistochemistry was used to validate the expression FOXD3 protein in 184 HGG cases. The association between FOXD3 expression and the prognosis of HGG patients were analyzed using Kaplan-Meier survival curves and Cox proportional hazards regression models. In addition, we further examined the effects of FOXD3 on the proliferation and serum starvation-induced apoptosis of glioma cells.

Results

In comparison to normal brain tissues, FOXD3 expression was significantly decreased in HGG tissues at both mRNA and protein levels. Immunohistochemistry further validated the expression of FOXD3 in HGG tissues. Moreover, low FOXD3 expression was significantly associated with poor prognosis in HGG patients. Depletion of FOXD3 expression promoted glioma cell proliferation and inhibited serum starvation-induced apoptosis, whereas overexpression of FOXD3 inhibited glioma cell proliferation and promoted serum starvation-induced apoptosis.

Conclusions

Our results indicated that FOXD3 might serve as an independent prognostic biomarker and a potential therapeutic target for HGGs, which warrant further investigation.

语种英语
WOS记录号WOS:000355183900175
资助机构First Affiliated Hospital of Zhengzhou University
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54219
专题北京大学第二临床医学院_神经外科
作者单位1.Zhengzhou Univ, Affiliated Hosp 1, Dept Neurosurg, Zhengzhou 450052, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Neurosurg, Beijing 100044, Peoples R China
3.Harbin Med Univ, Affiliated Hosp 2, Dept Gastroenterol, Harbin 150086, Peoples R China
4.Zhengzhou Univ, Affiliated Hosp 1, Prenatal Diag Ctr, Dept Gynecol & Obstet, Zhengzhou 450052, Peoples R China
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GB/T 7714
Du, Wei,Pang, Changhe,Wang, Dongliang,et al. Decreased FOXD3 Expression Is Associated with Poor Prognosis in Patients with High-Grade Gliomas[J]. PLOS ONE,2015,10(5).
APA Du, Wei.,Pang, Changhe.,Wang, Dongliang.,Zhang, Qingjun.,Xue, Yake.,...&Wei, Xinting.(2015).Decreased FOXD3 Expression Is Associated with Poor Prognosis in Patients with High-Grade Gliomas.PLOS ONE,10(5).
MLA Du, Wei,et al."Decreased FOXD3 Expression Is Associated with Poor Prognosis in Patients with High-Grade Gliomas".PLOS ONE 10.5(2015).
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