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学科主题: 临床医学
题名:
Decreased FOXD3 Expression Is Associated with Poor Prognosis in Patients with High-Grade Gliomas
作者: Du, Wei1; Pang, Changhe1; Wang, Dongliang2; Zhang, Qingjun2; Xue, Yake1; Jiao, Hongliang1; Zhan, Lei3; Ma, Qian4; Wei, Xinting1
刊名: PLOS ONE
发表日期: 2015-05-26
DOI: 10.1371/journal.pone.0127976
卷: 10, 期:5
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: CHRONIC LYMPHOCYTIC-LEUKEMIA ; TRANSCRIPTION FACTOR FOXD3 ; GASTRIC CARCINOGENESIS ; TUMOR-SUPPRESSOR ; MELANOMA-CELLS ; MURINE MODEL ; CANCER ; PROGRESSION ; REQUIREMENT ; DISEASE
英文摘要:

Background

The transcription factor forkhead box D3 (FOXD3) plays important roles in the development of neural crest and has been shown to suppress the development of various cancers. However, the expression and its potential biological roles of FOXD3 in high-grade gliomas (HGGs) remain unknown.

Methods

The mRNA and protein expression levels of FOXD3 were examined using real-time quantitative PCR and western blotting in 23 HGG and 13 normal brain samples, respectively. Immunohistochemistry was used to validate the expression FOXD3 protein in 184 HGG cases. The association between FOXD3 expression and the prognosis of HGG patients were analyzed using Kaplan-Meier survival curves and Cox proportional hazards regression models. In addition, we further examined the effects of FOXD3 on the proliferation and serum starvation-induced apoptosis of glioma cells.

Results

In comparison to normal brain tissues, FOXD3 expression was significantly decreased in HGG tissues at both mRNA and protein levels. Immunohistochemistry further validated the expression of FOXD3 in HGG tissues. Moreover, low FOXD3 expression was significantly associated with poor prognosis in HGG patients. Depletion of FOXD3 expression promoted glioma cell proliferation and inhibited serum starvation-induced apoptosis, whereas overexpression of FOXD3 inhibited glioma cell proliferation and promoted serum starvation-induced apoptosis.

Conclusions

Our results indicated that FOXD3 might serve as an independent prognostic biomarker and a potential therapeutic target for HGGs, which warrant further investigation.

语种: 英语
项目资助者: First Affiliated Hospital of Zhengzhou University
WOS记录号: WOS:000355183900175
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54219
Appears in Collections:北京大学第二临床医学院_神经外科_期刊论文

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作者单位: 1.Zhengzhou Univ, Affiliated Hosp 1, Dept Neurosurg, Zhengzhou 450052, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Neurosurg, Beijing 100044, Peoples R China
3.Harbin Med Univ, Affiliated Hosp 2, Dept Gastroenterol, Harbin 150086, Peoples R China
4.Zhengzhou Univ, Affiliated Hosp 1, Prenatal Diag Ctr, Dept Gynecol & Obstet, Zhengzhou 450052, Peoples R China

Recommended Citation:
Du, Wei,Pang, Changhe,Wang, Dongliang,et al. Decreased FOXD3 Expression Is Associated with Poor Prognosis in Patients with High-Grade Gliomas[J]. PLOS ONE,2015,10(5).
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