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学科主题: 药学
题名:
Microbial metabolism of evodiamine by Penicillium janthinellum and its application for metabolite identification in rat urine
作者: Li, Li; Liu, Rongxia; Ye, Min; Hu, Xinying; Wang, Qiao; Bi, Kaishun; Guo, Dean
关键词: evodiamine ; metabolite ; biotransformation ; hydroxylation
刊名: ENZYME AND MICROBIAL TECHNOLOGY
发表日期: 2006-08-02
DOI: 10.1016/j.enzmictec.2005.10.029
卷: 39, 期:4, 页:561-567
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biotechnology & Applied Microbiology
研究领域[WOS]: Biotechnology & Applied Microbiology
关键词[WOS]: MAMMALIAN METABOLISM ; MASS-SPECTROMETRY ; MODELS
英文摘要:

Microbial metabolism of evodiamine by Penicillium janthinellum AS 3.510 was investigated. Two metabolites were isolated from the broth and their structures were identified as 10-hydroxyevodiamine and 11-hydroxyevodiamine, by means of their IR, MS and NMR spectral data. Both of the metabolites were proved to be new compounds and showed strong cytotoxic activity in cytotoxicity assay. A major in vivo metabolite of evodiamine was detected in rat urine after oral administration of evodiamine and its structure was proved to be identical with that of the microbial metabolite 10-hydroxyevodiamine by HPLC-MS/MS analysis and comparison with the reference standard. The time course of microbial transformation of evodiamine and its urinary excretion in rat was proposed. (c) 2005 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000238932500006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54220
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
2.Shenyang Pharmaceut Univ, Sch Pharmaceut Sci, Shenyang 110016, Peoples R China

Recommended Citation:
Li, Li,Liu, Rongxia,Ye, Min,et al. Microbial metabolism of evodiamine by Penicillium janthinellum and its application for metabolite identification in rat urine[J]. ENZYME AND MICROBIAL TECHNOLOGY,2006,39(4):561-567.
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