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Microbial metabolism of evodiamine by Penicillium janthinellum and its application for metabolite identification in rat urine
Li, Li; Liu, Rongxia; Ye, Min; Hu, Xinying; Wang, Qiao; Bi, Kaishun; Guo, Dean
关键词Evodiamine Metabolite Biotransformation Hydroxylation
刊名ENZYME AND MICROBIAL TECHNOLOGY
2006-08-02
DOI10.1016/j.enzmictec.2005.10.029
39期:4页:561-567
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biotechnology & Applied Microbiology
研究领域[WOS]Biotechnology & Applied Microbiology
关键词[WOS]MAMMALIAN METABOLISM ; MASS-SPECTROMETRY ; MODELS
英文摘要

Microbial metabolism of evodiamine by Penicillium janthinellum AS 3.510 was investigated. Two metabolites were isolated from the broth and their structures were identified as 10-hydroxyevodiamine and 11-hydroxyevodiamine, by means of their IR, MS and NMR spectral data. Both of the metabolites were proved to be new compounds and showed strong cytotoxic activity in cytotoxicity assay. A major in vivo metabolite of evodiamine was detected in rat urine after oral administration of evodiamine and its structure was proved to be identical with that of the microbial metabolite 10-hydroxyevodiamine by HPLC-MS/MS analysis and comparison with the reference standard. The time course of microbial transformation of evodiamine and its urinary excretion in rat was proposed. (c) 2005 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000238932500006
Citation statistics
Cited Times:17[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54220
Collection北京大学药学院
作者单位1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
2.Shenyang Pharmaceut Univ, Sch Pharmaceut Sci, Shenyang 110016, Peoples R China
Recommended Citation
GB/T 7714
Li, Li,Liu, Rongxia,Ye, Min,et al. Microbial metabolism of evodiamine by Penicillium janthinellum and its application for metabolite identification in rat urine[J]. ENZYME AND MICROBIAL TECHNOLOGY,2006,39(4):561-567.
APA Li, Li.,Liu, Rongxia.,Ye, Min.,Hu, Xinying.,Wang, Qiao.,...&Guo, Dean.(2006).Microbial metabolism of evodiamine by Penicillium janthinellum and its application for metabolite identification in rat urine.ENZYME AND MICROBIAL TECHNOLOGY,39(4),561-567.
MLA Li, Li,et al."Microbial metabolism of evodiamine by Penicillium janthinellum and its application for metabolite identification in rat urine".ENZYME AND MICROBIAL TECHNOLOGY 39.4(2006):561-567.
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