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学科主题临床医学
Efficacy and safety of tadalafil taken as needed for the treatment of erectile dysfunction in Asian men: results of an integrated analysis
Guo, Ying-Lu2; Viswanathan, Vijay P.3; Chiang, Han-Sun4; Choi, Hyung Ki5; Yip, Andrew Wai Chun6; Shen, Wei; Kopernicky, Vladimir1
关键词Asia Comorbidity Erectile Dysfunction Phosphodiesterase Inhibitors Tadalafil
刊名ASIAN JOURNAL OF ANDROLOGY
2009-07-01
DOI10.1038/aja.2009.11
11期:4页:423-433
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Andrology ; Urology & Nephrology
研究领域[WOS]Endocrinology & Metabolism ; Urology & Nephrology
关键词[WOS]DOUBLE-BLIND ; SILDENAFIL CITRATE ; CLINICAL POPULATIONS ; INTERNATIONAL INDEX ; DEMAND TADALAFIL ; ORAL TADALAFIL ; 20 MG ; PLACEBO ; PARALLEL ; TOLERABILITY
英文摘要

We evaluated the efficacy and safety of as-needed tadalafil in a diverse clinical population (with varying patient demographics, disease severity, and comorbid medical conditions) of Asian men with erectile dysfunction (ED). An integrated analysis of five double-blind, placebo-controlled trials (N = 1 046) was performed. Patients were randomly assigned to receive 10 mg tadalafil (N = 185), 20 mg tadalafil (N = 510), or placebo (N = 351). Efficacy assessments included the International Index of Erectile Function (IIEF), Sexual Encounter Profile (SEP) diary and Global Assessment Question (GAQ). Patients receiving 10 mg or 20 mg tadalafil showed significant improvement from baseline-to-end point on the Erectile Function domain of the International Index of Erectile Function (IIEF-EF) domain score in all clinical sub-populations analyzed, compared with patients receiving placebo (P < 0.001). The 10-mg and 20-mg tadalafil groups showed a mean success rate of 64.1% and 70.5% for sexual intercourse attempts (SEP3, successful intercourse), respectively, compared with 33.4% in the placebo group (P < 0.001), and 85.5% and 85.4% reported improved erections at end point GAQ, respectively, versus 43.5% in the placebo group (P < 0.001). Tadalafil was well tolerated across all groups studied. Headache and back pain were the most frequently reported adverse events. Overall, tadalafil was effective and well tolerated across a diverse clinical spectrum of Asian men with ED.

语种英语
WOS记录号WOS:000267600800004
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54224
Collection北京大学第一临床医学院_男科中心
作者单位1.M V Hosp Diabet & Diabet Res Ctr, Madras 600013, Tamil Nadu, India
2.Fu Jen Catholic Univ, Sch Med, Taipei 24205, Taiwan
3.Yongdong Severance Hosp, Dept Urol, Seoul 135720, South Korea
4.Kwong Wah Hosp, Dept Surg, Hong Kong, Hong Kong, Peoples R China
5.Lilly Corp Ctr, LLC, Lilly USA, Indianapolis, IN 46285 USA
6.Peking Univ, Hosp 1, Androl Ctr, Beijing 100009, Peoples R China
Recommended Citation
GB/T 7714
Guo, Ying-Lu,Viswanathan, Vijay P.,Chiang, Han-Sun,et al. Efficacy and safety of tadalafil taken as needed for the treatment of erectile dysfunction in Asian men: results of an integrated analysis[J]. ASIAN JOURNAL OF ANDROLOGY,2009,11(4):423-433.
APA Guo, Ying-Lu.,Viswanathan, Vijay P..,Chiang, Han-Sun.,Choi, Hyung Ki.,Yip, Andrew Wai Chun.,...&Kopernicky, Vladimir.(2009).Efficacy and safety of tadalafil taken as needed for the treatment of erectile dysfunction in Asian men: results of an integrated analysis.ASIAN JOURNAL OF ANDROLOGY,11(4),423-433.
MLA Guo, Ying-Lu,et al."Efficacy and safety of tadalafil taken as needed for the treatment of erectile dysfunction in Asian men: results of an integrated analysis".ASIAN JOURNAL OF ANDROLOGY 11.4(2009):423-433.
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