北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第一临床医学院  > 男科中心  > 期刊论文
学科主题: 临床医学
题名:
Efficacy and safety of tadalafil taken as needed for the treatment of erectile dysfunction in Asian men: results of an integrated analysis
作者: Guo, Ying-Lu2; Viswanathan, Vijay P.3; Chiang, Han-Sun4; Choi, Hyung Ki5; Yip, Andrew Wai Chun6; Shen, Wei; Kopernicky, Vladimir1
关键词: Asia ; comorbidity ; erectile dysfunction ; phosphodiesterase inhibitors ; tadalafil
刊名: ASIAN JOURNAL OF ANDROLOGY
发表日期: 2009-07-01
DOI: 10.1038/aja.2009.11
卷: 11, 期:4, 页:423-433
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Andrology ; Urology & Nephrology
研究领域[WOS]: Endocrinology & Metabolism ; Urology & Nephrology
关键词[WOS]: DOUBLE-BLIND ; SILDENAFIL CITRATE ; CLINICAL POPULATIONS ; INTERNATIONAL INDEX ; DEMAND TADALAFIL ; ORAL TADALAFIL ; 20 MG ; PLACEBO ; PARALLEL ; TOLERABILITY
英文摘要:

We evaluated the efficacy and safety of as-needed tadalafil in a diverse clinical population (with varying patient demographics, disease severity, and comorbid medical conditions) of Asian men with erectile dysfunction (ED). An integrated analysis of five double-blind, placebo-controlled trials (N = 1 046) was performed. Patients were randomly assigned to receive 10 mg tadalafil (N = 185), 20 mg tadalafil (N = 510), or placebo (N = 351). Efficacy assessments included the International Index of Erectile Function (IIEF), Sexual Encounter Profile (SEP) diary and Global Assessment Question (GAQ). Patients receiving 10 mg or 20 mg tadalafil showed significant improvement from baseline-to-end point on the Erectile Function domain of the International Index of Erectile Function (IIEF-EF) domain score in all clinical sub-populations analyzed, compared with patients receiving placebo (P < 0.001). The 10-mg and 20-mg tadalafil groups showed a mean success rate of 64.1% and 70.5% for sexual intercourse attempts (SEP3, successful intercourse), respectively, compared with 33.4% in the placebo group (P < 0.001), and 85.5% and 85.4% reported improved erections at end point GAQ, respectively, versus 43.5% in the placebo group (P < 0.001). Tadalafil was well tolerated across all groups studied. Headache and back pain were the most frequently reported adverse events. Overall, tadalafil was effective and well tolerated across a diverse clinical spectrum of Asian men with ED.

语种: 英语
项目资助者: Lilly Research Laboratories ; Eli Lilly and Company ; Indianapolis, Indiana, USA
WOS记录号: WOS:000267600800004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54224
Appears in Collections:北京大学第一临床医学院_男科中心_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.M V Hosp Diabet & Diabet Res Ctr, Madras 600013, Tamil Nadu, India
2.Fu Jen Catholic Univ, Sch Med, Taipei 24205, Taiwan
3.Yongdong Severance Hosp, Dept Urol, Seoul 135720, South Korea
4.Kwong Wah Hosp, Dept Surg, Hong Kong, Hong Kong, Peoples R China
5.Lilly Corp Ctr, LLC, Lilly USA, Indianapolis, IN 46285 USA
6.Peking Univ, Hosp 1, Androl Ctr, Beijing 100009, Peoples R China

Recommended Citation:
Guo, Ying-Lu,Viswanathan, Vijay P.,Chiang, Han-Sun,et al. Efficacy and safety of tadalafil taken as needed for the treatment of erectile dysfunction in Asian men: results of an integrated analysis[J]. ASIAN JOURNAL OF ANDROLOGY,2009,11(4):423-433.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Guo, Ying-Lu]'s Articles
[Viswanathan, Vijay P.]'s Articles
[Chiang, Han-Sun]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Guo, Ying-Lu]‘s Articles
[Viswanathan, Vijay P.]‘s Articles
[Chiang, Han-Sun]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace