IR@PKUHSC  > 北京大学第一临床医学院  > 肾脏内科
学科主题临床医学
Clinicopathological Characteristics and Outcomes of Chinese Patients with Scanty Immune Deposits Lupus Nephritis: A Large Cohort Study from a Single Center
Li, Qiuyu1,2,3,4; Song, Di1,2,3,4; Wang, Fengmei1,2,3,4; Tan, Ying1,2,3,4; Yu, Feng1,2,3,4; Zhao, Minghui1,2,3,4
刊名SCIENTIFIC WORLD JOURNAL
2014
DOI10.1155/2014/212597
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]ANTINEUTROPHIL CYTOPLASMIC AUTOANTIBODIES ; ALTERNATIVE COMPLEMENT PATHWAY ; DISEASE-ACTIVITY ; PAUCI-IMMUNE ; C4B-BINDING PROTEIN ; INTRAVENOUS CYCLOPHOSPHAMIDE ; MYCOPHENOLATE-MOFETIL ; ACTIVATION PRODUCTS ; ERYTHEMATOSUS ; GLOMERULONEPHRITIS
英文摘要

Objective. To assess clinicopathological characteristics of lupus nephritis patients with scanty immune deposits. Methods. The data of patients with scanty immune deposits lupus nephritis were retrospectively analyzed. Plasma ANCA and complement components were detected. Results. Among 316 cases with renal biopsy-proven lupus nephritis, 40 cases were diagnosed as scanty immune deposits. There were significantly higher value of serum creatinine (P = 0.002) and lower hemoglobin level (P = 0.009) and higher score of cellular crescents (P = 0.015) in scanty immune deposits group compared with immune complex deposits group. The frequency of positive plasma ANCA was significantly higher in scanty immune deposits group than that in immune complex deposits group (52.5% versus 10.1%, P < 0.001). As for comparisons of plasma complement components, there were significantly higher levels of C1q (P = 0.005) and Bb (P = 0.02) and lower level of factor H (P = 0.003) in scanty immune deposits group. The ratio of treatment failure was significantly higher in scanty immune deposits group than that in immune deposits group (42.5% versus 19.20%, P = 0.001). The renal outcomes were similar between the two groups. Conclusions. Patients with scanty immune deposits lupus nephritis had more severe kidney damage. ANCA and activation of complement alternative pathway might be involved in the pathogenesis of the disease.

语种英语
WOS记录号WOS:000331312700001
项目编号2012CB517702 ; 81021004 ; 81100497
资助机构Grant of Chinese 973 Project ; National Natural Science Foundation of China to Innovation Research Group ; National Natural Science Foundation of China
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54225
专题北京大学第一临床医学院_肾脏内科
作者单位1.Minist Hlth China, Key Lab Renal Dis, Beijing 100034, Peoples R China
2.Peking Univ, Hosp 1, Dept Med, Div Renal, Beijing 100034, Peoples R China
3.Peking Univ, Inst Nephrol, Beijing 100034, Peoples R China
4.Minist Educ, Key Lab Chron Kidney Dis Prevent & Treatment, Beijing 100034, Peoples R China
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GB/T 7714
Li, Qiuyu,Song, Di,Wang, Fengmei,et al. Clinicopathological Characteristics and Outcomes of Chinese Patients with Scanty Immune Deposits Lupus Nephritis: A Large Cohort Study from a Single Center[J]. SCIENTIFIC WORLD JOURNAL,2014.
APA Li, Qiuyu,Song, Di,Wang, Fengmei,Tan, Ying,Yu, Feng,&Zhao, Minghui.(2014).Clinicopathological Characteristics and Outcomes of Chinese Patients with Scanty Immune Deposits Lupus Nephritis: A Large Cohort Study from a Single Center.SCIENTIFIC WORLD JOURNAL.
MLA Li, Qiuyu,et al."Clinicopathological Characteristics and Outcomes of Chinese Patients with Scanty Immune Deposits Lupus Nephritis: A Large Cohort Study from a Single Center".SCIENTIFIC WORLD JOURNAL (2014).
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