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学科主题: 临床医学
题名:
Clinicopathological Characteristics and Outcomes of Chinese Patients with Scanty Immune Deposits Lupus Nephritis: A Large Cohort Study from a Single Center
作者: Li, Qiuyu1,2,3,4; Song, Di1,2,3,4; Wang, Fengmei1,2,3,4; Tan, Ying1,2,3,4; Yu, Feng1,2,3,4; Zhao, Minghui1,2,3,4
刊名: SCIENTIFIC WORLD JOURNAL
发表日期: 2014
DOI: 10.1155/2014/212597
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: ANTINEUTROPHIL CYTOPLASMIC AUTOANTIBODIES ; ALTERNATIVE COMPLEMENT PATHWAY ; DISEASE-ACTIVITY ; PAUCI-IMMUNE ; C4B-BINDING PROTEIN ; INTRAVENOUS CYCLOPHOSPHAMIDE ; MYCOPHENOLATE-MOFETIL ; ACTIVATION PRODUCTS ; ERYTHEMATOSUS ; GLOMERULONEPHRITIS
英文摘要:

Objective. To assess clinicopathological characteristics of lupus nephritis patients with scanty immune deposits. Methods. The data of patients with scanty immune deposits lupus nephritis were retrospectively analyzed. Plasma ANCA and complement components were detected. Results. Among 316 cases with renal biopsy-proven lupus nephritis, 40 cases were diagnosed as scanty immune deposits. There were significantly higher value of serum creatinine (P = 0.002) and lower hemoglobin level (P = 0.009) and higher score of cellular crescents (P = 0.015) in scanty immune deposits group compared with immune complex deposits group. The frequency of positive plasma ANCA was significantly higher in scanty immune deposits group than that in immune complex deposits group (52.5% versus 10.1%, P < 0.001). As for comparisons of plasma complement components, there were significantly higher levels of C1q (P = 0.005) and Bb (P = 0.02) and lower level of factor H (P = 0.003) in scanty immune deposits group. The ratio of treatment failure was significantly higher in scanty immune deposits group than that in immune deposits group (42.5% versus 19.20%, P = 0.001). The renal outcomes were similar between the two groups. Conclusions. Patients with scanty immune deposits lupus nephritis had more severe kidney damage. ANCA and activation of complement alternative pathway might be involved in the pathogenesis of the disease.

语种: 英语
所属项目编号: 2012CB517702 ; 81021004 ; 81100497
项目资助者: Grant of Chinese 973 Project ; National Natural Science Foundation of China to Innovation Research Group ; National Natural Science Foundation of China
WOS记录号: WOS:000331312700001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54225
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: 1.Minist Hlth China, Key Lab Renal Dis, Beijing 100034, Peoples R China
2.Peking Univ, Hosp 1, Dept Med, Div Renal, Beijing 100034, Peoples R China
3.Peking Univ, Inst Nephrol, Beijing 100034, Peoples R China
4.Minist Educ, Key Lab Chron Kidney Dis Prevent & Treatment, Beijing 100034, Peoples R China

Recommended Citation:
Li, Qiuyu,Song, Di,Wang, Fengmei,et al. Clinicopathological Characteristics and Outcomes of Chinese Patients with Scanty Immune Deposits Lupus Nephritis: A Large Cohort Study from a Single Center[J]. SCIENTIFIC WORLD JOURNAL,2014.
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