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学科主题: 药学
题名:
Antitumor activity of dichloroacetate on C6 glioma cell: in vitro and in vivo evaluation
作者: Duan, Yu1; Zhao, Xin1; Ren, Wei1; Wang, Xin1; Yu, Ke-Fu1; Li, Dan1; Zhang, Xuan1; Zhang, Qiang1,2
关键词: dichloroacetate ; DCA ; C6 glioma ; antitumor efficacy ; in vitro ; in vivo
刊名: ONCOTARGETS AND THERAPY
发表日期: 2013
DOI: 10.2147/OTT.S40992
卷: 6, 页:189-198
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biotechnology & Applied Microbiology ; Oncology
研究领域[WOS]: Biotechnology & Applied Microbiology ; Oncology
关键词[WOS]: HUMAN SKELETAL-MUSCLE ; HEAT-SHOCK PROTEINS ; CANCER-CELLS ; MALIGNANT GLIOMA ; LACTIC-ACIDOSIS ; BRAIN-TUMORS ; THERAPY ; APOPTOSIS ; METABOLISM ; MITOCHONDRIA
英文摘要:

Dichloroacetate (DCA), a small molecule mitochondria-targeting agent, can penetrate the blood-brain barrier, showing potential therapeutic effects on brain tumors. Considering the effects of DCA on tumor cellular metabolism, penetrating across the blood-brain barrier, as well as having potential antitumor activity on brain tumors, the purpose of this study is to investigate the antitumor activity of DCA on C6 glioma cells in vitro and in vivo. DCA inhibited C6 glioma cell proliferation, induced C6 cell apoptosis, and arrested C6 cells in S phase. DCA can inhibit the expression of heat shock proteins 70 (Hsp70) in a dose-dependent and time-dependent manner (P < 0.01). Our in vivo antitumor effect results indicated that DCA markedly inhibited the growth of C6 glioma tumors in both C6 brain tumor-bearing rats and C6 tumor-bearing nude mice (P < 0.01). DCA significantly induced the ROS production and decreased the mitochondrial membrane potential in tumor tissues. Our in vivo antitumor effect results also indicated that DCA has potential antiangiogenic effects. In conclusion, DCA may be a viable therapeutic agent in the treatment of gliomas.

语种: 英语
所属项目编号: 81172992 ; 2009CB930300 ; 2013CB932501 ; BMU20110263
项目资助者: National Natural Science Foundation of China ; National Basic Research Program of China (973 Program) ; Innovation Team of the Ministry of Education
WOS记录号: WOS:000315993800001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54232
Appears in Collections:北京大学药学院_药剂学系_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, Dept Pharmaceut, Beijing 100191, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

Recommended Citation:
Duan, Yu,Zhao, Xin,Ren, Wei,et al. Antitumor activity of dichloroacetate on C6 glioma cell: in vitro and in vivo evaluation[J]. ONCOTARGETS AND THERAPY,2013,6:189-198.
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